Detailed information of TA system TA231536

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapC-vagC/VapC-VagC
• Location: 3363358..3363995
• Replicon: chromosome
• Accession: NZ_CP090635
• Organism: Burkholderia contaminans strain FFI45

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: LXE92_RS15895
• Protein ID: WP_278128670.1
• Coordinates: 3363594..3363995 (+)
• Length: 134 a.a.

Antitoxin (Protein)

• Gene name: vagC
• Uniprot ID: A0A1E3FXY0
• Locus tag: LXE92_RS15890
• Protein ID: WP_039351357.1
• Coordinates: 3363358..3363594 (+)
• Length: 79 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LXE92_RS15875 (LXE92_15825)	3359049..3360081	+	1033	Protein_3110	helix-turn-helix domain-containing protein	-
LXE92_RS15880 (LXE92_15830)	3360199..3361296	-	1098	WP_278128666.1	ADP-heptose--LPS heptosyltransferase	-
LXE92_RS15885 (LXE92_15835)	3361293..3362996	-	1704	WP_278128668.1	thiamine pyrophosphate-binding protein	-
LXE92_RS15890 (LXE92_15840)	3363358..3363594	+	237	WP_039351357.1	type II toxin-antitoxin system VapB family antitoxin	Antitoxin
LXE92_RS15895 (LXE92_15845)	3363594..3363995	+	402	WP_278128670.1	type II toxin-antitoxin system VapC family toxin	Toxin
LXE92_RS15900 (LXE92_15850)	3364066..3365454	-	1389	WP_039351351.1	L-serine ammonia-lyase	-
LXE92_RS15905 (LXE92_15855)	3365485..3366621	-	1137	Protein_3116	alginate lyase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (4-120)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 134 a.a.
• Molecular weight: 14895.01 Da
• Isoelectric Point: 4.7351

>T231536 WP_278128670.1 NZ_CP090635:3363594-3363995 [Burkholderia contaminans]
MPRYMLDTNMCIYLMKNQPEQVARRFAQCYTGDVVMSAITYAELEYGVAACASPARERGNLAALIDDIPVAPFDVAAAQA
YGPVREATRERKKDHLDKLIAAHAVSLDVVLVTNNERDFVSYPGLRLENWLED

Nucleotide

• Length: 402 bp

>T231536 NZ_CP126927:10204-10620 [Escherichia coli O2:K1:H5]
GTGAACAAGATCTATATGCTCGACACGAACATCTGCTCGTTCATCATGCGCGAGCAACCTGAAGCATTGCTTAAGCACCT
GGAGCAGTCGGTGCTGCGCGGTCACCGTATCGTGGTCTCGGCCATCACCTACTCCGAGATGCGCTTCGGTGCCACCGGTC
CGAAGGCCTCGCCACGCCACGTGCAACTGGTTGACGCGTTCTGTGAGAGGCTCGATGCCGTCCTGCCGTGGGACCGCGCC
GCGGTGGATGCGACCACGGAGATTAAGGTGGCACTGCGTCTCGCCGGCACGCCGATCGGTCCGAACGACACGGCGATAGC
CGGACACGCCATCGCTGCCTGTGCCATTCTGGTGACGAATAATGTGAGAGAGTTTGAGCGGGTACCGGGTCTTGTGCTGG
AAGACTGGGTAAGATAA

Antitoxin

Protein

• Length: 79 a.a.
• Molecular weight: 9008.13 Da
• Isoelectric Point: 6.4720

>AT231536 WP_039351357.1 NZ_CP090635:3363358-3363594 [Burkholderia contaminans]
MHTTRVFRNGNSQAVRIPADLAYERSDIELEIERIGDEIRIRPARRPLTRVLEKFAKFGPDFMADGRGDHEQADREGL

Nucleotide

• Length: 237 bp

>AT231536 NZ_CP126927:9977-10207 [Escherichia coli O2:K1:H5]
ATGAGAACCGTATCCATTTTTAAAAATGGCAACAACCGTGCTATCCGCCTTCCACGCGATCTGGATTTTGAGGGGGTGAG
CGAGCTGGAGATCGTCCGGGAAGGGGACAGCATCATTCTGCGCCCCGTCCGGCCGACCTGGGGCTCATTCCTGGAGCTAG
AAAAGGCCGATCCGGACTTTATGACGGAGCGCGAGGACGTTGTCAGCGACGAAGGACGAGTTAACCTGTGA

Structures

Antitoxin

• AlphaFold DB: A0A1E3FXY0