Detailed information of TA system TA231535

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tad-ata/Tad-HTH_37
• Location: 2268481..2269163
• Replicon: chromosome
• Accession: NZ_CP090635
• Organism: Burkholderia contaminans strain FFI45

Toxin (Protein)

• Gene name: tad
• Uniprot ID: -
• Locus tag: LXE92_RS10750
• Protein ID: WP_278127927.1
• Coordinates: 2268481..2268843 (+)
• Length: 121 a.a.

Antitoxin (Protein)

• Gene name: ata
• Uniprot ID: -
• Locus tag: LXE92_RS10755
• Protein ID: WP_071334802.1
• Coordinates: 2268840..2269163 (+)
• Length: 108 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LXE92_RS10725 (LXE92_10690)	2264310..2264765	+	456	WP_039370381.1	VOC family protein	-
LXE92_RS10730 (LXE92_10695)	2264833..2266383	-	1551	WP_039370375.1	sodium:solute symporter family protein	-
LXE92_RS10735 (LXE92_10700)	2266380..2266622	-	243	WP_011352801.1	DUF3311 domain-containing protein	-
LXE92_RS10740 (LXE92_10705)	2266821..2267738	-	918	WP_071334799.1	spermidine synthase	-
LXE92_RS10745 (LXE92_10710)	2267883..2268137	+	255	WP_071334800.1	hypothetical protein	-
LXE92_RS10750 (LXE92_10715)	2268481..2268843	+	363	WP_278127927.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
LXE92_RS10755 (LXE92_10720)	2268840..2269163	+	324	WP_071334802.1	helix-turn-helix transcriptional regulator	Antitoxin
LXE92_RS10760 (LXE92_10725)	2269225..2269701	-	477	WP_278127929.1	DNA-deoxyinosine glycosylase	-
LXE92_RS10765 (LXE92_10730)	2269701..2270297	-	597	WP_039370667.1	chorismate lyase	-
LXE92_RS10770 (LXE92_10735)	2270306..2272204	-	1899	WP_278127931.1	molecular chaperone HtpG	-
LXE92_RS10775 (LXE92_10740)	2272363..2273823	-	1461	WP_039370360.1	PLP-dependent aminotransferase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (17-109)

Antitoxin

• Cro/C1-type helix-turn-helix domain (30-85)

Sequences

Toxin

Protein

• Length: 121 a.a.
• Molecular weight: 13417.35 Da
• Isoelectric Point: 9.7779

>T231535 WP_278127927.1 NZ_CP090635:2268481-2268843 [Burkholderia contaminans]
MDPYIKPLYWLGSARRDLKAMPQAVQDTFGYALYLAQTGRKHDQAKPLKGFGSAGMLEIVESEDNGTYRAVYTVKLGSSV
YVLHCFQKKSSIGIATPRPDSDLVRERLKAAEAHEQGVRR

Nucleotide

• Length: 363 bp

>T231535 NZ_CP126927:5341-5757 [Escherichia coli O2:K1:H5]
GTGAACAAGATCTATATGCTCGACACGAACATCTGCTCGTTCATCATGCGCGAGCAGCCTGAAGCAGTGCTTAAGAATCT
GGAGCAGGCGGTGCTGCGCGGTCACCGTATCGTGGTCTCGGCCATCACCTACTCCGAGATGCGCTTCGGCGCCACCGGTC
CAAAGGCATCGCCACGCCACGTGCAGCTGGTTGACGCGTTCTGCGCCCGTCTCGATGCCATCCTGCCCTGGGATCGCGCT
GCGGTGGATGCAACCACGGAGGTTAAGGTGGCGCTGCGCCTCGCCGGCACGCCGATCGGTCCAAACGACACGGCGATCGC
CGGGCACGCCATCGCCACCGGGGCAATACTGGTGACGAATAATGTGAGAGAGTTTGAGCGGGTGCCTGGACTGGTACTGG
AAGACTGGGCAGGATAA

Antitoxin

Protein

• Length: 108 a.a.
• Molecular weight: 11778.63 Da
• Isoelectric Point: 6.8708

>AT231535 WP_071334802.1 NZ_CP090635:2268840-2269163 [Burkholderia contaminans]
MIEIEQGSGNVYADLGMHDAAEMQVKAQLAAKIAEIIKARQWTQQHAARLLGITQPKLSNMLRGQFRGVSETKMLECLAK
LGRDVHIVVGPDRQSEVEGHIEVVFAA

Nucleotide

• Length: 324 bp

>AT231535 NZ_CP126927:5114-5344 [Escherichia coli O2:K1:H5]
ATGAGAACCGTATCTATTTTCAAAAATGGCAATAACCGCGCGATCCGTCTGCCCCGCGATCTGGATTTTGAGGGGGTGAG
TGAGCTGGAGATTGTACGGGAAGGGGACAGAATCATTCTGCGTCCCCTCCGCCCGAGCTGGAGCTCATTCCTGGAGCTAG
AAAAGGCCGATCCGGGCTTTATGACGGAACGCGAGGACGTTGTCTGCGACGAAGGACGATTTAACCTGTGA