Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 775006..775528 Replicon chromosome
Accession NZ_CP090635
Organism Burkholderia contaminans strain FFI45

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag LXE92_RS03745 Protein ID WP_278129540.1
Coordinates 775235..775528 (+) Length 98 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag LXE92_RS03740 Protein ID WP_059468969.1
Coordinates 775006..775248 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LXE92_RS03705 (LXE92_03695) 770160..770453 + 294 WP_059670902.1 phage holin family protein -
LXE92_RS03710 (LXE92_03700) 770446..770865 + 420 WP_278129532.1 glycoside hydrolase family protein -
LXE92_RS03715 (LXE92_03705) 770862..771356 + 495 WP_278129533.1 DUF2514 family protein -
LXE92_RS03720 (LXE92_03710) 771525..772313 + 789 WP_278129535.1 DNA adenine methylase -
LXE92_RS03725 (LXE92_03715) 772424..773311 + 888 WP_278129537.1 hypothetical protein -
LXE92_RS03730 (LXE92_03720) 773364..773999 - 636 WP_278129539.1 hypothetical protein -
LXE92_RS03735 (LXE92_03725) 774074..774730 + 657 WP_278130409.1 SOS response-associated peptidase family protein -
LXE92_RS03740 (LXE92_03730) 775006..775248 + 243 WP_059468969.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
LXE92_RS03745 (LXE92_03735) 775235..775528 + 294 WP_278129540.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LXE92_RS03750 (LXE92_03740) 775992..777260 + 1269 WP_278129541.1 DUF1835 domain-containing protein -
LXE92_RS03755 (LXE92_03745) 777935..778666 - 732 WP_278129542.1 WYL domain-containing protein -
LXE92_RS03760 (LXE92_03750) 778755..779375 + 621 WP_278129543.1 hypothetical protein -
LXE92_RS03765 (LXE92_03755) 779462..779761 - 300 Protein_732 DDE transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(8-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(8-76)


Sequences

Toxin        


Download         Length: 98 a.a.        Molecular weight: 11131.17 Da        Isoelectric Point: 10.3601

>T231532 WP_278129540.1 NZ_CP090635:775235-775528 [Burkholderia contaminans]
MKTYKLKFVVDALKEWEKLDKTVREQFKKKLAERLENPRVPSAKLSGDLDDCYKIKLLALGYRLVYRVDDTVVTVTVIAV
GKRERSAVYAAAVARLK

Download         Length: 294 bp

>T231532 NZ_CP126926:c4752854-4752681 [Escherichia coli O2:K1:H5]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTTCTGGTCGGAATAACCTGGCCAATGAGTCTTCCTGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8639.89 Da        Isoelectric Point: 4.1370

>AT231532 WP_059468969.1 NZ_CP090635:775006-775248 [Burkholderia contaminans]
MESILARTSIGISELKVNPTAAIEQADGPVAVLNRNRPVAYLIPAAEWEAICDRLEDVELAAIVRARLGQEAVSVNLEDL

Download         Length: 243 bp

>AT231532 NZ_CP126926:c4753178-4752882 [Escherichia coli O2:K1:H5]
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCAGTGTTCTTAAGGTT
AAGATCATTGATGTATGATATGAATTTCTCCTCTATCGTGGCTGATGAATATGGGATACCACGACAATTGAATGAAAACT
CCTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTCAAATGCTTAGACTTACCGGATATT
GATTTTGACCTCAGCATTATGACAGTTGATGACTATTTCCGTCAGTTTTACAAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References