Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/upstrm_HI1419-dnstrm_HI1420
Location 2742056..2742697 Replicon chromosome
Accession NZ_CP090633
Organism Burkholderia contaminans strain FFH2055

Toxin (Protein)


Gene name relE Uniprot ID A0A6P3A5N9
Locus tag LXE93_RS28910 Protein ID WP_046549447.1
Coordinates 2742056..2742394 (+) Length 113 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A1J9PWC2
Locus tag LXE93_RS28915 Protein ID WP_039344756.1
Coordinates 2742398..2742697 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LXE93_RS28900 (LXE93_28860) 2738621..2740054 - 1434 WP_046549448.1 aldehyde dehydrogenase family protein -
LXE93_RS28905 (LXE93_28865) 2740084..2741724 - 1641 WP_039344750.1 acetolactate synthase large subunit -
LXE93_RS28910 (LXE93_28870) 2742056..2742394 + 339 WP_046549447.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LXE93_RS28915 (LXE93_28875) 2742398..2742697 + 300 WP_039344756.1 putative addiction module antidote protein Antitoxin
LXE93_RS28920 (LXE93_28880) 2742764..2744050 - 1287 WP_046549446.1 DUF445 domain-containing protein -
LXE93_RS28925 (LXE93_28885) 2744221..2745441 - 1221 WP_046549445.1 anthranilate 1,2-dioxygenase system ferredoxin--NAD(+) reductase -
LXE93_RS28930 (LXE93_28890) 2745431..2745757 - 327 WP_006479527.1 anthranilate 1,2-dioxygenase ferredoxin subunit AndAb -
LXE93_RS28935 (LXE93_28895) 2745778..2746266 - 489 WP_011355917.1 anthranilate 1,2-dioxygenase small subunit AndAd -
LXE93_RS28940 (LXE93_28900) 2746280..2747551 - 1272 WP_039344770.1 anthranilate 1,2-dioxygenase large subunit AndAc -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(16-107)

Antitoxin

Uncharacterized protein HI1420

(6-93)


Sequences

Toxin        


Download         Length: 113 a.a.        Molecular weight: 12655.53 Da        Isoelectric Point: 8.9480

>T231531 WP_046549447.1 NZ_CP090633:2742056-2742394 [Burkholderia contaminans]
MVDILQSMPYSAPTFSIRTTDVFDTWFAGLQDRVAKRRIQARIDRLSMGNPGDWKSAGSPVVEMRIDHGPGYRVYYVRRG
TIWVILLCGGDKSTQQADIRAAHAMLAHLDME

Download         Length: 339 bp

>T231531 NZ_CP126926:4739416-4739793 [Escherichia coli O2:K1:H5]
ATGAATACATTACCCGACACTCACGTACGGGAGGCATCGGGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTATGGCCTCACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGGATTTCACTGTGTGACGCGGTGAACTTTCTCGTTGAAAAATACGCGCTGGTACGTACCGACCAGCCGGGATTC
AGCGCAGGAGCCCCGTCGCAGTTAATCAACAGCATTGATATTCTCCGGGCTCGCAGGGCAACCGGCCTGATGACCCGGAA
CAATTACAGAATGGTAAATAACATTACCCAAGGCAAGCATCCGGAGGCAAAACAATGA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10649.01 Da        Isoelectric Point: 6.3217

>AT231531 WP_039344756.1 NZ_CP090633:2742398-2742697 [Burkholderia contaminans]
MDKISTRPWDSADHLKTEDDMADYFEACLQEAGDDPAFIAHALGVIARARGMSQVARDAGLSREGLYKALSHDGNPSFGT
ILKVIKALGLQLHGSKAHA

Download         Length: 300 bp

>AT231531 NZ_CP126926:4738992-4739369 [Escherichia coli O2:K1:H5]
GTGTCAGACACACTGCCCGGGACAACGCATCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGTGCCGGTATCAGAGGCCGGT
TCAGCGACGCGGATGCATACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCATCACACTGTATGCGAAAGGGCTGACCTGCGAAGCCGATACCCTTGGCAGTTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCGGCAGCGCCCGCAATCACCGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6P3A5N9

Antitoxin

Source ID Structure
AlphaFold DB A0A1J9PWC2

References