Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 1759394..1760033 Replicon chromosome
Accession NZ_CP090633
Organism Burkholderia contaminans strain FFH2055

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag LXE93_RS24625 Protein ID WP_226148243.1
Coordinates 1759617..1760033 (+) Length 139 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A1X1PQC0
Locus tag LXE93_RS24620 Protein ID WP_039351245.1
Coordinates 1759394..1759630 (+) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LXE93_RS24605 (LXE93_24570) 1755702..1756220 + 519 WP_081421049.1 flavin reductase family protein -
LXE93_RS24610 (LXE93_24575) 1756236..1757303 + 1068 WP_046547961.1 ferredoxin--NADP reductase -
LXE93_RS24615 (LXE93_24580) 1757347..1758927 + 1581 WP_046547960.1 FadD3 family acyl-CoA ligase -
LXE93_RS24620 (LXE93_24585) 1759394..1759630 + 237 WP_039351245.1 DNA-binding protein Antitoxin
LXE93_RS24625 (LXE93_24590) 1759617..1760033 + 417 WP_226148243.1 type II toxin-antitoxin system VapC family toxin Toxin
LXE93_RS24630 (LXE93_24595) 1760233..1761129 + 897 WP_046547958.1 VOC family protein -
LXE93_RS24635 (LXE93_24600) 1761139..1762032 + 894 WP_046547957.1 CoA-transferase -
LXE93_RS24640 (LXE93_24605) 1762043..1762840 + 798 WP_046547956.1 ketoacid CoA transferase -
LXE93_RS24645 (LXE93_24610) 1762849..1763781 + 933 WP_046547955.1 enoyl-CoA hydratase -
LXE93_RS24650 (LXE93_24615) 1763778..1764866 + 1089 WP_046547954.1 nitronate monooxygenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-128)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 15340.66 Da        Isoelectric Point: 8.5855

>T231530 WP_226148243.1 NZ_CP090633:1759617-1760033 [Burkholderia contaminans]
VYLIDTNIISEIRKGKRTNRGVRAFFRQAAADASPLYLSVVTVAELRRGVDLIRHRGDHPQASALEAWMATILSGYAPNI
LPVDIEISQMWGHLRVPDPTHELDKLIAATALINDLTVVTRNVADFARTGVRLLNPFD

Download         Length: 417 bp

>T231530 NZ_CP126926:4256048-4256200 [Escherichia coli O2:K1:H5]
ATGAAGCAGCATAAGGCGATGATTGTCGCCCTGATCGTCATCTGTATCACCGCCGTAGTGGCGGCGCTGGTAACGAGAAA
AGACCTCTGTGAGGTTCACATCCGAACTGGCCAGACGGAGGTTGCTGTTTTCACGGCTTACGAATCCGAGTAA

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8598.61 Da        Isoelectric Point: 5.0477

>AT231530 WP_039351245.1 NZ_CP090633:1759394-1759630 [Burkholderia contaminans]
MANLLVRNVDDSIVQSLREQAAANGRSAEAEHRAILADALGRPKRKTFAQVLMSMPDVGDDADFQRVQDSGEARRVFD

Download         Length: 237 bp

>AT231530 NZ_CP126926:c4255999-4255942 [Escherichia coli O2:K1:H5]
GTTCTGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A1X1PQC0

References