Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | phd-doc/HTH_IclR(antitoxin) |
| Location | 1487511..1489261 | Replicon | chromosome |
| Accession | NZ_CP090633 | ||
| Organism | Burkholderia contaminans strain FFH2055 | ||
Toxin (Protein)
| Gene name | doc | Uniprot ID | - |
| Locus tag | LXE93_RS23445 | Protein ID | WP_046548148.1 |
| Coordinates | 1487511..1488407 (+) | Length | 299 a.a. |
Antitoxin (Protein)
| Gene name | phd | Uniprot ID | A0A3N8Q8T8 |
| Locus tag | LXE93_RS23450 | Protein ID | WP_046548147.1 |
| Coordinates | 1488404..1489261 (+) | Length | 286 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LXE93_RS23415 (LXE93_23385) | 1482881..1483960 | - | 1080 | WP_039344086.1 | porin | - |
| LXE93_RS23420 (LXE93_23390) | 1484405..1484722 | + | 318 | WP_011354710.1 | non-heme iron oxygenase ferredoxin subunit | - |
| LXE93_RS23425 (LXE93_23395) | 1484724..1485035 | + | 312 | WP_046548150.1 | hypothetical protein | - |
| LXE93_RS23430 (LXE93_23400) | 1485088..1486164 | + | 1077 | WP_039344090.1 | aromatic ring-hydroxylating dioxygenase subunit alpha | - |
| LXE93_RS23435 (LXE93_23405) | 1486157..1486927 | + | 771 | WP_046548149.1 | SDR family oxidoreductase | - |
| LXE93_RS23440 (LXE93_23410) | 1486965..1487492 | + | 528 | WP_039344094.1 | cupin domain-containing protein | - |
| LXE93_RS23445 (LXE93_23415) | 1487511..1488407 | + | 897 | WP_046548148.1 | alpha/beta fold hydrolase | Toxin |
| LXE93_RS23450 (LXE93_23420) | 1488404..1489261 | + | 858 | WP_046548147.1 | IclR family transcriptional regulator | Antitoxin |
| LXE93_RS23455 (LXE93_23425) | 1489258..1490055 | + | 798 | WP_046548146.1 | SDR family oxidoreductase | - |
| LXE93_RS23460 (LXE93_23430) | 1490048..1491715 | + | 1668 | WP_046548145.1 | thiamine pyrophosphate-binding protein | - |
| LXE93_RS23465 (LXE93_23435) | 1491708..1492535 | + | 828 | WP_046548144.1 | aspartate dehydrogenase | - |
| LXE93_RS23470 (LXE93_23440) | 1492608..1494098 | + | 1491 | WP_046548143.1 | aldehyde dehydrogenase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 299 a.a. Molecular weight: 30735.01 Da Isoelectric Point: 8.3561
>T231529 WP_046548148.1 NZ_CP090633:1487511-1488407 [Burkholderia contaminans]
MSVIDKRERDRTAAFAALLGQFPERRCAAGAAGTIGYREAGAQHAGRALPVVLLHGIGSGAASWVRQLDTLGASRRVLAW
DAPGYGVSTSVHGASPAATDYAASLNAWLEALGIERCVLVGHSLGAIIAGGLIRVMPARIAGLLLVSPAGGYGSAPAETR
DARRDARLAMLAELGPAGLAEQRSGNMLSGFANEDARAWVRWNMARIVPAGYAQATHLLANADLATDLAGFRGRTAVAVG
ANDAITPPAACERVAAAAHVGLQVIPQAGHAGYVEAPAVYSALIDTFCRQCDQQRGLA
MSVIDKRERDRTAAFAALLGQFPERRCAAGAAGTIGYREAGAQHAGRALPVVLLHGIGSGAASWVRQLDTLGASRRVLAW
DAPGYGVSTSVHGASPAATDYAASLNAWLEALGIERCVLVGHSLGAIIAGGLIRVMPARIAGLLLVSPAGGYGSAPAETR
DARRDARLAMLAELGPAGLAEQRSGNMLSGFANEDARAWVRWNMARIVPAGYAQATHLLANADLATDLAGFRGRTAVAVG
ANDAITPPAACERVAAAAHVGLQVIPQAGHAGYVEAPAVYSALIDTFCRQCDQQRGLA
Download Length: 897 bp
>T231529 NZ_CP126926:c3984705-3984307 [Escherichia coli O2:K1:H5]
ATGCGGGTATTCAAAACAAAACTTATTCGCCTGCAACTTACAGCAGAGGAACTTGAAGCGTTAACGGCGGATTTTATTTC
CTATAAGCGTGACGGTGTTTTGCCAGATATATTTGGTCGTGATGCACTCTACGACGACTCGTTTACCTGGCCATTAATCA
AATTTGAGCGAGTTGCTCATATTCATCTGGCAAATGTGAATAATCCATTTCCGCCACAGTTGCGCCAATTCAGCAGAACG
AATGACGCAGCGCATTTGGTATATTGTCAGGGCGCGTTTGATGAGCAAGCATGGTTGCTCATTGCCATTCTGAAACCTGA
ACCTCATAAACTGGCTCGAGATAACAACCAAATGCATAAAATTGGGAAAATGGCAGAAGCGTTTCGCATGCGTTTTTGA
ATGCGGGTATTCAAAACAAAACTTATTCGCCTGCAACTTACAGCAGAGGAACTTGAAGCGTTAACGGCGGATTTTATTTC
CTATAAGCGTGACGGTGTTTTGCCAGATATATTTGGTCGTGATGCACTCTACGACGACTCGTTTACCTGGCCATTAATCA
AATTTGAGCGAGTTGCTCATATTCATCTGGCAAATGTGAATAATCCATTTCCGCCACAGTTGCGCCAATTCAGCAGAACG
AATGACGCAGCGCATTTGGTATATTGTCAGGGCGCGTTTGATGAGCAAGCATGGTTGCTCATTGCCATTCTGAAACCTGA
ACCTCATAAACTGGCTCGAGATAACAACCAAATGCATAAAATTGGGAAAATGGCAGAAGCGTTTCGCATGCGTTTTTGA
Antitoxin
Download Length: 286 a.a. Molecular weight: 31376.93 Da Isoelectric Point: 6.5061
>AT231529 WP_046548147.1 NZ_CP090633:1488404-1489261 [Burkholderia contaminans]
MNEPLQQPELENGKAEASYVVPGLERGLRILAEFSPREPVLGAPELSKRLGIPRTTVFRLLQTLESLGFLERADKDRNYK
LGIAVLRLGFEYLSSLELTDLGLPVIESLRDATGFTTHIVIRDGRDVVFVAKAQSQAPVFSSIRVNVGTRLPAHATTHGH
VLMGDLSLKELHALYPEGALNRMTNATPETVDALYEVIREDALRGYGVSNSSFERGISVVTAPVRNETQKIVACITVTVP
RPEIDAALIADGLIDKVQRAAAELSRRLNYRSDDEHTFLKALGLR
MNEPLQQPELENGKAEASYVVPGLERGLRILAEFSPREPVLGAPELSKRLGIPRTTVFRLLQTLESLGFLERADKDRNYK
LGIAVLRLGFEYLSSLELTDLGLPVIESLRDATGFTTHIVIRDGRDVVFVAKAQSQAPVFSSIRVNVGTRLPAHATTHGH
VLMGDLSLKELHALYPEGALNRMTNATPETVDALYEVIREDALRGYGVSNSSFERGISVVTAPVRNETQKIVACITVTVP
RPEIDAALIADGLIDKVQRAAAELSRRLNYRSDDEHTFLKALGLR
Download Length: 858 bp
>AT231529 NZ_CP126926:c3985001-3984708 [Escherichia coli O2:K1:H5]
ATGCATCGAATTCTCGCTGAAAAATCGGTCAATATCACTGAGTTACGTAAAAACCCAGCTAAATACTTTATTGATCAACC
TGTTGCGGTTCTTTCTAATAATCGCCCCGCAGGATATCTCTTAAGTGCCAGCGCATTTGAAGCATTAATGGACATGCTTG
CAGAACAAGAGGAGAAAAAGCCCATAAAGGCGCGCTTCCGTCCGAGTGCTGCAAGATTAGAGGAAATTACACGCCGCGCT
GAACAATATCTTAATGATATGACGGATGATGATTTCAATGACTTTAAGGAATAA
ATGCATCGAATTCTCGCTGAAAAATCGGTCAATATCACTGAGTTACGTAAAAACCCAGCTAAATACTTTATTGATCAACC
TGTTGCGGTTCTTTCTAATAATCGCCCCGCAGGATATCTCTTAAGTGCCAGCGCATTTGAAGCATTAATGGACATGCTTG
CAGAACAAGAGGAGAAAAAGCCCATAAAGGCGCGCTTCCGTCCGAGTGCTGCAAGATTAGAGGAAATTACACGCCGCGCT
GAACAATATCTTAATGATATGACGGATGATGATTTCAATGACTTTAAGGAATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|