Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 1295694..1296349 Replicon chromosome
Accession NZ_CP090633
Organism Burkholderia contaminans strain FFH2055

Toxin (Protein)


Gene name vapC Uniprot ID A0A4R4BYV1
Locus tag LXE93_RS22435 Protein ID WP_046548294.1
Coordinates 1295930..1296349 (+) Length 140 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A4R4C038
Locus tag LXE93_RS22430 Protein ID WP_046548594.1
Coordinates 1295694..1295933 (+) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LXE93_RS22405 (LXE93_22375) 1290948..1291343 - 396 WP_046548595.1 type II toxin-antitoxin system VapC family toxin -
LXE93_RS22410 (LXE93_22380) 1291340..1291579 - 240 WP_010089452.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
LXE93_RS22415 (LXE93_22385) 1291677..1292360 - 684 WP_046548297.1 Fe2+-dependent dioxygenase -
LXE93_RS22420 (LXE93_22390) 1292357..1293136 - 780 WP_046548296.1 tetratricopeptide repeat protein -
LXE93_RS22425 (LXE93_22395) 1293140..1295383 - 2244 WP_046548295.1 TonB-dependent siderophore receptor -
LXE93_RS22430 (LXE93_22400) 1295694..1295933 + 240 WP_046548594.1 Arc family DNA-binding protein Antitoxin
LXE93_RS22435 (LXE93_22405) 1295930..1296349 + 420 WP_046548294.1 type II toxin-antitoxin system VapC family toxin Toxin
LXE93_RS22440 (LXE93_22410) 1296466..1297761 - 1296 WP_039360985.1 aspartate carbamoyltransferase -
LXE93_RS22445 (LXE93_22415) 1297995..1298129 + 135 WP_006485835.1 entericidin A/B family lipoprotein -
LXE93_RS22450 (LXE93_22420) 1298229..1298777 - 549 WP_046548293.1 hypothetical protein -
LXE93_RS22455 (LXE93_22425) 1298986..1299954 - 969 WP_046548292.1 DMT family transporter -
LXE93_RS22460 (LXE93_22430) 1300150..1300944 - 795 WP_046548291.1 AraC family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-122)

Antitoxin

Arc-like DNA binding domain

(7-46)


Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 15151.41 Da        Isoelectric Point: 5.7471

>T231528 WP_046548294.1 NZ_CP090633:1295930-1296349 [Burkholderia contaminans]
MILVDTNVMSEPLRREPSAAVIEWLDAQNVETLFLAAISLGEMRFGVAALPEGRRRDWLHHSIEQRVVPLFRGRILPFDD
AASKAYASIRARARASGSTIAPADVFIAATAEANGLIIATRDVAPFEAVGLRVIDPWAS

Download         Length: 420 bp

>T231528 NZ_CP126926:3785191-3785409 [Escherichia coli O2:K1:H5]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGTCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 8776.06 Da        Isoelectric Point: 6.4684

>AT231528 WP_046548594.1 NZ_CP090633:1295694-1295933 [Burkholderia contaminans]
MPVITVRNLPDEVHRALRIRAAQHGRSTEAEVRDILEQAVLPGGRLKLGTLLAEIGREAGGVEFDVRRDKTLTDPMSFE

Download         Length: 240 bp

>AT231528 NZ_CP126926:3784791-3785165 [Escherichia coli O2:K1:H5]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGCCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTTAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4R4BYV1

Antitoxin

Source ID Structure
AlphaFold DB A0A4R4C038

References