Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 2278016..2278695 Replicon chromosome
Accession NZ_CP090632
Organism Burkholderia contaminans strain FFH2055

Toxin (Protein)


Gene name vagD Uniprot ID -
Locus tag LXE93_RS10585 Protein ID WP_081421109.1
Coordinates 2278016..2278432 (-) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID -
Locus tag LXE93_RS10590 Protein ID WP_046545686.1
Coordinates 2278429..2278695 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LXE93_RS10565 (LXE93_10535) 2274324..2274491 - 168 WP_105815830.1 type II toxin-antitoxin system RelE/ParE family toxin -
LXE93_RS10570 (LXE93_10540) 2274517..2275680 - 1164 WP_046545689.1 M20 aminoacylase family protein -
LXE93_RS10575 (LXE93_10545) 2276008..2277093 + 1086 WP_249039904.1 type IV toxin-antitoxin system AbiEi family antitoxin -
LXE93_RS10580 (LXE93_10550) 2277062..2277967 + 906 WP_046545687.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein -
LXE93_RS10585 (LXE93_10555) 2278016..2278432 - 417 WP_081421109.1 PIN domain-containing protein Toxin
LXE93_RS10590 (LXE93_10560) 2278429..2278695 - 267 WP_046545686.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
LXE93_RS10595 (LXE93_10565) 2278945..2279961 - 1017 WP_046545685.1 GNAT family N-acetyltransferase -
LXE93_RS10600 (LXE93_10570) 2279961..2280800 - 840 WP_046545684.1 formyltransferase family protein -
LXE93_RS10605 (LXE93_10575) 2280887..2283148 - 2262 WP_046545683.1 TonB-dependent siderophore receptor -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-130)

Antitoxin

SpoVT-AbrB domain

(7-55)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 14557.59 Da        Isoelectric Point: 6.8603

>T231527 WP_081421109.1 NZ_CP090632:c2278432-2278016 [Burkholderia contaminans]
VTTLYMLDTNICSFIMRERPPVVLSRLQSCVNAQHRIVVSAVSYAEMRFGAVGGKASPKHAELVTAFVSRLDGVLSWDTA
AVDATAAIRADFASRGTPIGTNDASIAGHAIAAGAVLVTHDSREFGRVAGLTLEDWAA

Download         Length: 417 bp

>T231527 NZ_CP126926:c3756069-3755767 [Escherichia coli O2:K1:H5]
ATGGCTCAAAAGAAAAATATAAGGAGTTTTCGTGATGCCTGGTTGGCTGATTTTTTTGTCCATTCAACGCCACATCGAAA
GATCCCTGCTGAAATCCATACCACGTTATCACGAAAGTTGGACATCATTAATGCTGCCACTTCTCATTGGGATTTACGCT
CCCCTCCGGGGAACCGATACGAAGAGTTATCCGGGAAATTACAGGAATACTCCTCCATTAGAGTGAATAAACAGTACCGA
CTGATTTTTAAATGGGTTAATGGCAAGGCCGAAGAATTGTTTTTAGACCCACACAACTACTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9685.91 Da        Isoelectric Point: 4.3449

>AT231527 WP_046545686.1 NZ_CP090632:c2278695-2278429 [Burkholderia contaminans]
MRTVSIFKNARNQAIRIPKDMEFEGVTELEIRREGDTLLLLPVRPTWLSFASEPPADADFLAERPSVIEPGRFDLSDGGG
AAPTESGQ

Download         Length: 267 bp

>AT231527 NZ_CP126926:c3755731-3755390 [Escherichia coli O2:K1:H5]
ATGAAACAGGCAACAAGAAAACCGACGACACCCGGAGATATTCTTCTCTATGAATATCTGGAACCGCTCGATTTGAAAAT
CAATGAGTTAGCAGAGTTGCTGCATGTTCATCGTAATAGCGTCAGTGCACTGATCAATAACAATCGTAAACTCACCACTG
AGATGGCATTCCGTCTGGCGAAAGTTTTTGATACCACAGTCGATTTTTGGCTAAACCTCCAGGCGGCAGTTGATCTTTGG
GAAGTTGAAAACAACATGCGTACCCAGGAAGAATTGGGACGGATTGAAACAGTGGCTGAATATTTGGCACGCCGTGAAGA
GCGTGCAAAAAAGGTCGCGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References