231526

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tad-ata/Tad-HTH_37
Location 1449821..1450503 Replicon chromosome
Accession NZ_CP090632
Organism Burkholderia contaminans strain FFH2055

Toxin (Protein)


Gene name tad Uniprot ID A0A6P2YP52
Locus tag LXE93_RS06670 Protein ID WP_046544690.1
Coordinates 1450141..1450503 (-) Length 121 a.a.

Antitoxin (Protein)


Gene name ata Uniprot ID -
Locus tag LXE93_RS06665 Protein ID WP_046544689.1
Coordinates 1449821..1450144 (-) Length 108 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LXE93_RS06645 (LXE93_06630) 1445168..1446628 + 1461 WP_039370360.1 PLP-dependent aminotransferase family protein -
LXE93_RS06650 (LXE93_06635) 1446787..1448685 + 1899 WP_046544687.1 molecular chaperone HtpG -
LXE93_RS06655 (LXE93_06640) 1448694..1449290 + 597 WP_046546267.1 chorismate lyase -
LXE93_RS06660 (LXE93_06645) 1449290..1449766 + 477 WP_046544688.1 DNA-deoxyinosine glycosylase -
LXE93_RS06665 (LXE93_06650) 1449821..1450144 - 324 WP_046544689.1 helix-turn-helix transcriptional regulator Antitoxin
LXE93_RS06670 (LXE93_06655) 1450141..1450503 - 363 WP_046544690.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LXE93_RS06675 (LXE93_06660) 1450847..1451149 - 303 WP_235441948.1 hypothetical protein -
LXE93_RS06680 (LXE93_06665) 1451246..1452163 + 918 WP_046544691.1 spermidine synthase -
LXE93_RS06685 (LXE93_06670) 1452362..1452604 + 243 WP_046544692.1 DUF3311 domain-containing protein -
LXE93_RS06690 (LXE93_06675) 1452601..1454151 + 1551 WP_046544693.1 sodium:solute symporter family protein -
LXE93_RS06695 (LXE93_06680) 1454219..1454674 - 456 WP_046544694.1 VOC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(16-109)

Antitoxin

Cro/C1-type helix-turn-helix domain

(30-85)


Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13299.24 Da        Isoelectric Point: 9.9311

>T231526 WP_046544690.1 NZ_CP090632:c1450503-1450141 [Burkholderia contaminans]
MDPYIKPLYWLGSARKDLKAMPQAVQDTFGYALYLAQTGRKHDQAKPLKGFGSAGVLEIVESEDNGTYRAVYTVKLGSSV
YVLHCFQKKSSIGIATPRPDSDLVRERLKAAEAHAQGVRR

Download         Length: 363 bp

>T231526 NZ_CP126926:3031446-3031553 [Escherichia coli O2:K1:H5]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 108 a.a.        Molecular weight: 11806.68 Da        Isoelectric Point: 7.3600

>AT231526 WP_046544689.1 NZ_CP090632:c1450144-1449821 [Burkholderia contaminans]
MIEIEQGSGNVYADLGMHDAAEMRVKAQLAAKIAEIIKARQWTQQHAARLLGITQPKLSNMLRGQFRGVSETKMLECLAK
LGRDVHIVVGPDRQSEVEGHIEVVFAA

Download         Length: 324 bp

>AT231526 NZ_CP126926:c3031393-3031332 [Escherichia coli O2:K1:H5]
TGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6P2YP52

Antitoxin

Source ID Structure

References