Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4879047..4879563 Replicon chromosome
Accession NZ_CP090629
Organism Klebsiella pneumoniae isolate KpBO_TO1

Toxin (Protein)


Gene name relE Uniprot ID J2XDK6
Locus tag L0105_RS24330 Protein ID WP_002886902.1
Coordinates 4879047..4879331 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag L0105_RS24335 Protein ID WP_002886901.1
Coordinates 4879321..4879563 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L0105_RS24305 (L0105_24305) 4874531..4874794 - 264 WP_004152271.1 PTS sugar transporter subunit IIB -
L0105_RS24310 (L0105_24310) 4874924..4875097 + 174 WP_002886906.1 hypothetical protein -
L0105_RS24315 (L0105_24315) 4875100..4875843 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
L0105_RS24320 (L0105_24320) 4876200..4878338 + 2139 WP_002886904.1 anaerobic ribonucleoside-triphosphate reductase -
L0105_RS24325 (L0105_24325) 4878579..4879043 + 465 WP_002886903.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
L0105_RS24330 (L0105_24330) 4879047..4879331 - 285 WP_002886902.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
L0105_RS24335 (L0105_24335) 4879321..4879563 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
L0105_RS24340 (L0105_24340) 4879641..4881551 - 1911 WP_004152270.1 PRD domain-containing protein -
L0105_RS24345 (L0105_24345) 4881574..4882728 - 1155 WP_002886900.1 lactonase family protein -
L0105_RS24350 (L0105_24350) 4882794..4883534 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.3787

>T231522 WP_002886902.1 NZ_CP090629:c4879331-4879047 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T231522 NZ_CP126926:1188828-1189163 [Escherichia coli O2:K1:H5]
ATGGTAAGCCGATACGTACCCGATACGGGCGATCTGATTTGGGTTGATTTTGACCCGACAAAAGGTAGCGAGCAAGCCGG
ACATCGTCCGGCTGTTGTCCTGAGTCCGTTCATGTACAACAACAAAACAGGTATGTGTCTGTGTGTTCCTTGTACAACGC
AATCAAAAGGATATCCGTTCGAAGTTGTTCTATCCGGTCAGGAACGTGATGGCGTAGCGTTAGCTGATCAGGTAAAAAGT
ATCGCCTGGCGGGCAAGAGGAGCAACGAAGAAAGGAACAGTTGCCCCAGAGGAATTACAACTCATTAAAGCCAAAATTAA
CGTGCTGATTGGGTAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT231522 WP_002886901.1 NZ_CP090629:c4879563-4879321 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT231522 NZ_CP126926:1188580-1188828 [Escherichia coli O2:K1:H5]
ATGATCCACAGTAGCGTAAAGCGTTGGGGAAATTCACCGGCGGTGCGGATCCCGGCTACGTTAATGCAGGCGCTCAATCT
GAATATTGATGATGAAGTGAAGATTGACCTGGTGGATGGCAAATTAATTATTGAGCCAGTGCGTAAAGAGCCCGTATTTA
CGCTTGCTGAACTGGTCAACGACATCACGCCGGAAAACCTCCACGAGAATATCGACTGGGGGGAGCCGAAAGATAAGGAA
GTCTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GMH2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References