Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4163064..4163683 Replicon chromosome
Accession NZ_CP090629
Organism Klebsiella pneumoniae isolate KpBO_TO1

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag L0105_RS20900 Protein ID WP_002892050.1
Coordinates 4163465..4163683 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag L0105_RS20895 Protein ID WP_002892066.1
Coordinates 4163064..4163438 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L0105_RS20885 (L0105_20885) 4158216..4159409 + 1194 WP_002892072.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
L0105_RS20890 (L0105_20890) 4159432..4162578 + 3147 WP_002892069.1 multidrug efflux RND transporter permease subunit AcrB -
L0105_RS20895 (L0105_20895) 4163064..4163438 + 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
L0105_RS20900 (L0105_20900) 4163465..4163683 + 219 WP_002892050.1 HHA domain-containing protein Toxin
L0105_RS20905 (L0105_20905) 4163842..4164408 + 567 WP_002892030.1 maltose O-acetyltransferase -
L0105_RS20910 (L0105_20910) 4164380..4164520 - 141 WP_004147370.1 hypothetical protein -
L0105_RS20915 (L0105_20915) 4164541..4165011 + 471 WP_002892026.1 YlaC family protein -
L0105_RS20920 (L0105_20920) 4164986..4166437 - 1452 WP_002892023.1 PLP-dependent aminotransferase family protein -
L0105_RS20925 (L0105_20925) 4166538..4167236 + 699 WP_002892021.1 GNAT family protein -
L0105_RS20930 (L0105_20930) 4167233..4167373 - 141 WP_002892018.1 type B 50S ribosomal protein L36 -
L0105_RS20935 (L0105_20935) 4167373..4167636 - 264 WP_002892011.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T231520 WP_002892050.1 NZ_CP090629:4163465-4163683 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T231520 NZ_CP126926:c914403-913993 [Escherichia coli O2:K1:H5]
ATGAAATTATTACCCGACACACATGTACGGGAGGCATCGTGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAT
CCGTCTGCTGGACCAGCACTATGGCCTCACACTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCCGGCATTTCACTGTGCGATGCGGTGAACTTTCTCGTTGAAAAATACGCACTGGTACGTACCGACCAGCCGGGATTC
AGCGCAGGAGCCCCGTCGCAGTTAATCAACAGCATCGATATTCTCCGGGCCCGCCGGGCAACAGGCCTGATGACACGTAA
TAACTACAGAATGGTAAATAACATTACCCTGGGTAGCATCCGGGGGCGAAACGATGAAACTTTCCCTGACGCTGGAAGCC
GACAGCGTTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT231520 WP_002892066.1 NZ_CP090629:4163064-4163438 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT231520 NZ_CP126926:c914862-914494 [Escherichia coli O2:K1:H5]
GTGTCAGACACACTCTCCGGGATAACTCATCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTTCCCTGCACAGTGAG
GCCCTGTTTTGGCGCCCGTCTGGTGCAGGAGGGTAACCGCCTGCATTACCTTGCCGACCGCGCCGGCATCAGAGGCCGGT
TCAGCGATGCGGATGCATACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCGAAGCCGACACCCTCGGCAGTTG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAACGAAAAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References