Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 874333..874990 Replicon chromosome
Accession NZ_CP090629
Organism Klebsiella pneumoniae isolate KpBO_TO1

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag L0105_RS04405 Protein ID WP_002916310.1
Coordinates 874580..874990 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag L0105_RS04400 Protein ID WP_002916312.1
Coordinates 874333..874599 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L0105_RS04375 (L0105_04375) 869489..870922 - 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -
L0105_RS04380 (L0105_04380) 871041..871769 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
L0105_RS04385 (L0105_04385) 871819..872130 + 312 WP_002916319.1 N(4)-acetylcytidine aminohydrolase -
L0105_RS04390 (L0105_04390) 872294..872953 + 660 WP_002916317.1 hemolysin III family protein -
L0105_RS04395 (L0105_04395) 873104..874087 - 984 WP_002916313.1 tRNA-modifying protein YgfZ -
L0105_RS04400 (L0105_04400) 874333..874599 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
L0105_RS04405 (L0105_04405) 874580..874990 + 411 WP_002916310.1 protein YgfX Toxin
L0105_RS04410 (L0105_04410) 874997..875518 - 522 WP_002916308.1 flavodoxin FldB -
L0105_RS04415 (L0105_04415) 875619..876515 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
L0105_RS04420 (L0105_04420) 876538..877251 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
L0105_RS04425 (L0105_04425) 877257..878990 + 1734 WP_004151783.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T231510 WP_002916310.1 NZ_CP090629:874580-874990 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T231510 NZ_CP126683:48995-49246 [Pantoea agglomerans]
ATGAGAGCAATCAGTTACAGCGAAGCCCGACAAAATCTGTCTGCCACTATGGTTCAGACGGTTGAAGATAAAGCGCCGGT
ATTAATCACCCGCCAGAACGGTGAATCCTGCGTGCTGATGTCGCTTGAAGAATATAACTCACTGGAAGAGACAGCCTACC
TGCTGCGGTCACCTAAGAATGCTCGCAGGTTAATGGATTCCATCGAAAGCCTGCAAAGCGGTAACGGGACTGACAGGGAT
ATTATTGAGTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT231510 WP_002916312.1 NZ_CP090629:874333-874599 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT231510 NZ_CP126683:49243-49497 [Pantoea agglomerans]
GTGAAACTGACCTGGTCCGAAGAAACCTGGGAAGATTATCTCTACTGGCAGGATACCGATAAAAAAACGGTCAAAAAGAT
TAATGAGTTGCTAAAAGATGCCAGCAGGACGCCTTTTGAAGGCAAAGGAAAACCCGAGCCATTAAAGCATAATCTTGCAG
GCTTCTGGTCACGCAGAATTACGGCAGAACATCGGCTGGTTTACGCCGTCAGTGGAGACGCTTTATTAATCGCCTCATGC
CGTTATCACTATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References