Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mosAT/AbiEii-AbiEi
Location 5038935..5040616 Replicon chromosome
Accession NZ_CP090626
Organism Klebsiella pneumoniae isolate KpBO_TO3

Toxin (Protein)


Gene name mosT Uniprot ID W8V1Q6
Locus tag L0104_RS25150 Protein ID WP_002885155.1
Coordinates 5038935..5039852 (-) Length 306 a.a.

Antitoxin (Protein)


Gene name mosA Uniprot ID W8UPQ8
Locus tag L0104_RS25155 Protein ID WP_004151732.1
Coordinates 5039858..5040616 (-) Length 253 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L0104_RS25130 (L0104_25130) 5034241..5035761 + 1521 WP_002885173.1 sugar ABC transporter ATP-binding protein -
L0104_RS25135 (L0104_25135) 5035758..5036756 + 999 WP_002885172.1 ribose ABC transporter permease -
L0104_RS25140 (L0104_25140) 5036787..5037728 + 942 WP_002885156.1 ABC transporter substrate-binding protein -
L0104_RS25145 (L0104_25145) 5037803..5038810 + 1008 WP_004151731.1 carbohydrate kinase family protein -
L0104_RS25150 (L0104_25150) 5038935..5039852 - 918 WP_002885155.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
L0104_RS25155 (L0104_25155) 5039858..5040616 - 759 WP_004151732.1 type IV toxin-antitoxin system AbiEi family antitoxin Antitoxin
L0104_RS25160 (L0104_25160) 5040702..5041430 - 729 WP_002885152.1 response regulator transcription factor -
L0104_RS25165 (L0104_25165) 5041703..5043850 + 2148 WP_077598858.1 formate dehydrogenase subunit alpha -
L0104_RS25170 (L0104_25170) 5044080..5044766 + 687 WP_004151733.1 tetratricopeptide repeat protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Nucleotidyl transferase AbiEii toxin, Type IV TA system

(14-278)

Antitoxin

Transcriptional regulator, AbiEi 3 antitoxin, Type IV TA system

(95-246)


Sequences

Toxin        


Download         Length: 306 a.a.        Molecular weight: 34687.15 Da        Isoelectric Point: 5.4707

>T231504 WP_002885155.1 NZ_CP090626:c5039852-5038935 [Klebsiella pneumoniae]
MDIQAPYYRQVALLMQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIAANLQQQ
AGMSAVLQANRSDEMRVIVTTDSAQIKIEVSPVARGTLYPPQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQH
PRDFYDVKLLLDAQELDRPIFNGFIVYLLSHNRPLAEVLNPRWKDIAEPFYREFSGMTFETIALEELTAVPNRMIAALKS
CFTQQDVDFLLSFKRGEPDWRLAPEMRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS

Download         Length: 918 bp

>T231504 NZ_CP126681:2087472-2088785 [Pantoea agglomerans]
ATGCAAAGGCTGATTGCGTGGATGAACGGCGAGCGGGTAGGCGTGCTCACCCGGCAGCGGAATGGCGCTCATGAGTTTCA
GTATGACACCGGCTGGCTGAGTAACCCGCTATCCAGGCCACTGTCACTTTCTCTGCCGCTGCAGGTTAAGGCAATCACCT
CACACGCCGTGATTAACTTCTTCGATAACCTGCTGCCAGATAGCCCGCTGATTCGTGACAGAATCGTGGCGCGTTACCAG
ATTAAATCCCGTCAGCCGTTTGACCTGTTGCAGGAAGTGGGACGTGACAGCGTCGGGGCGACTATGCTGTTGCCGCCCGA
TATGCCGCTGCCCGCGCTGCAGGCTCGCTATGAGGTGCTGGATGAAGCCCGGCTTGAGAGTGTGCTGTCAGCCTATCAGT
CAGATATCCCGCTGGGGATGTTGCGTGAAGAGACTGACTTCCGCATTTCGGTGGCGGGCGCACAGGAGAAAACGGCGCTG
CTGCTGACCGAAGAGGGCTGGAGCATTCCTGCCGGTGCCACGCCCACCTCGCACATCATTAAGCTGCCGATCGGTGAGAT
TAAACAGCCAGCCGCGACGCTGGATATGCGTGAAAGCGTAGAGAATGAGTATCTCTGTCTGGCGCTGGTCCGCGCACTGG
GTATTGATGTGCCGCAGGCGACGATTATCCGGGCCGGTAAGATGCGCGCCCTGGCCGTTGAGCGCTTTGATCGCCGCTGG
TCGCGCGACCGAACCCGGCTGATTCGTCTGCCACAGGAGGATTTCTGTCAGGCGCTGGGGCTGCCATCCTCGACCAAATA
TGCGTCGGACGGCGGGCCGGGCATTGCAGAAATAATGCAGATACTGATGGGATCGAGCAACGCCATTGAAGATCGCTATC
GCTTTATGATGTTCCAGGTGTTTCAGTGGCTGATTGGTGCTACCGATGGTCACGCAAAAAACTTCTCGCTGTTTATTGAG
CGCGGCGGCAGTTATCGACTGACACCCTTTTATGATGTGATCTCCGCTTATCCGGTGCTGGGCGGTACCGGCCTGAACAG
GCGTGCACTAAAGCTTGCGATGGGGCTGCGTGCCACTAAGGGGAAGAAGACAGAAATCGACAAAATCTTTCCGCGCCATT
TTATCGCCACGGCAAAAAGCGTCAGTTTTGATCGTGACAGTTTGCAGCAGATCTTCGACTTCTTCGTCCGTGAGTTTCCC
AAAGCGGTGGTCTCAGTGCGCGAGGCCTTACCGGCCGATTATCCACAGCACATCGCCGACGCCATTTTCAGTCATTCACT
GATTATGCTGGAGCGGCTGCGGCACAAAGAGTGA

Antitoxin


Download         Length: 253 a.a.        Molecular weight: 28564.92 Da        Isoelectric Point: 10.0870

>AT231504 WP_004151732.1 NZ_CP090626:c5040616-5039858 [Klebsiella pneumoniae]
MATKLNWLLQNSAPGDVILQSWLSQHAISPSLSFKYAQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSVENKALLPKWFREFPGVEWIVISGKKLPVLDDRYRVTLDIKGKKLIGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQAKRLYLFFASFYEHGWLKRIDSQKIDLGAGKRQIVENGKFNAQ
YQITVPERFQKE

Download         Length: 759 bp

>AT231504 NZ_CP126681:2087224-2087472 [Pantoea agglomerans]
ATGATATACAGCCCGCTACAGCTGGCAAACCGGCTAAAGCTTATCCGCCAGCGCAACGGCTGGACCCAGAGTGAACTGGC
GAAAAAGGTTGGCCTGAAACAGGCTACCATCTCTCACTTTGAAAATGCGCCTGACACTACCTCGCTGGCCACGCTGTTTA
AGCTTTTACAGGCGCTGGAAGTGAGTCTGGACGTAGTGGAAAAAGAGGAGGCCAGTGCGCCTCAATTGCATGATGAGGAT
GCGTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GH11

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GQB5

References