Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4880097..4880613 Replicon chromosome
Accession NZ_CP090626
Organism Klebsiella pneumoniae isolate KpBO_TO3

Toxin (Protein)


Gene name relE Uniprot ID J2XDK6
Locus tag L0104_RS24335 Protein ID WP_002886902.1
Coordinates 4880097..4880381 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag L0104_RS24340 Protein ID WP_002886901.1
Coordinates 4880371..4880613 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L0104_RS24310 (L0104_24310) 4875581..4875844 - 264 WP_004152271.1 PTS sugar transporter subunit IIB -
L0104_RS24315 (L0104_24315) 4875974..4876147 + 174 WP_002886906.1 hypothetical protein -
L0104_RS24320 (L0104_24320) 4876150..4876893 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
L0104_RS24325 (L0104_24325) 4877250..4879388 + 2139 WP_002886904.1 anaerobic ribonucleoside-triphosphate reductase -
L0104_RS24330 (L0104_24330) 4879629..4880093 + 465 WP_002886903.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
L0104_RS24335 (L0104_24335) 4880097..4880381 - 285 WP_002886902.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
L0104_RS24340 (L0104_24340) 4880371..4880613 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
L0104_RS24345 (L0104_24345) 4880691..4882601 - 1911 WP_004152270.1 PRD domain-containing protein -
L0104_RS24350 (L0104_24350) 4882624..4883778 - 1155 WP_002886900.1 lactonase family protein -
L0104_RS24355 (L0104_24355) 4883844..4884584 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.3787

>T231503 WP_002886902.1 NZ_CP090626:c4880381-4880097 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T231503 NZ_CP126681:1597519-1597872 [Pantoea agglomerans]
GTGTGGATGATTAAAACGACAGAGCGGTTTGATCGCTGGTTTACGTTGCTTAATGACAGCGATCGCGCCTGCGTGCTGGC
TGCATTGATGGTGCTGCGGGAAAAGGGGCCGGGATTAAGCCGACCCTATGCGGATACGATTAAAGGTTCCGCTTATATCA
ACATGAAAGAGTTACGTATCCAGAGCCGCGGCGACCCAATAAGGGCTTTCTTTGCTTTTGACCCGAACCGCACGGCAATT
GTGCTGTGTGCCGGTAATAAGGCGGGCAATGAAAAGCGATTTTATCGGGAGATGCTTCCGGTTGCCGATCGGGAATTCAC
ACACTGGCTAAAAAGCTTTAACCATAAGGAGTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT231503 WP_002886901.1 NZ_CP090626:c4880613-4880371 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT231503 NZ_CP126681:1597877-1598179 [Pantoea agglomerans]
ATGGGCAGAACGCTGGAACAGCTTATTGCGGATGAAAAACCGGAAGTCGTTGCCGACGCACAGGCTATGGCGACCGAAAT
CCTGCTCAACATTCACCTTGCCGAGCTGCGTGAGAAAGTGCAGAAAACGCAAGTGGAAATGGCGCAGGCGCTGGGCATCA
CACAGCCGACCGTGGCGGGCATGGAAAAGCCGGGGCGTGACCTGAAGCTTTCCACGCTCAAACGTTATGTCGATGCGGCA
GGGGGGAAACTGCGGCTGGTGGTAGAGTTGCCGGATGGTTCCCACTACGGGTTCGTGGTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GMH2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References