Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2719538..2721126 Replicon chromosome
Accession NZ_CP090626
Organism Klebsiella pneumoniae isolate KpBO_TO3

Toxin (Protein)


Gene name hipA Uniprot ID W8UI36
Locus tag L0104_RS13590 Protein ID WP_002904792.1
Coordinates 2719538..2720860 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A0H3GXD8
Locus tag L0104_RS13595 Protein ID WP_002904790.1
Coordinates 2720860..2721126 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L0104_RS13575 (L0104_13575) 2714594..2717095 + 2502 WP_004151634.1 fimbria/pilus outer membrane usher protein -
L0104_RS13580 (L0104_13580) 2717083..2718087 + 1005 WP_002904798.1 fimbrial protein -
L0104_RS13585 (L0104_13585) 2718229..2719521 + 1293 WP_002904794.1 glycoside hydrolase family 10 protein -
L0104_RS13590 (L0104_13590) 2719538..2720860 - 1323 WP_002904792.1 type II toxin-antitoxin system HipA family toxin Toxin
L0104_RS13595 (L0104_13595) 2720860..2721126 - 267 WP_002904790.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
L0104_RS13600 (L0104_13600) 2721392..2721718 - 327 WP_002904788.1 hydroxyisourate hydrolase -
L0104_RS13605 (L0104_13605) 2721715..2722215 - 501 WP_002904787.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
L0104_RS13610 (L0104_13610) 2722193..2723572 - 1380 WP_002904785.1 nucleobase:cation symporter-2 family protein -
L0104_RS13615 (L0104_13615) 2723918..2725072 + 1155 WP_002904783.1 FAD-dependent urate hydroxylase HpxO -
L0104_RS13620 (L0104_13620) 2725053..2725976 - 924 WP_002904781.1 LysR family hpxDE operon transcriptional regulator HpxR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(149-402)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49171.46 Da        Isoelectric Point: 7.5357

>T231500 WP_002904792.1 NZ_CP090626:c2720860-2719538 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

>T231500 NZ_CP126631:1517490-1517642 [Staphylococcus aureus]
ATGTCTAAAGACAAAGACCCAAAATTAAATTATCATGAAGAAGAAAACAGTATGGTAACTGATTTTGAAGATTTAAAAGA
ATTAGGTAAAGAAATGGAACAAATTTCTGATCAAAATGATCAAGAAAAGAATTCTGAAGAAGACAGTCAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9906.27 Da        Isoelectric Point: 8.5912

>AT231500 WP_002904790.1 NZ_CP090626:c2721126-2720860 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp

>AT231500 NZ_CP126631:1516866-1517465 [Staphylococcus aureus]
ATGGCAATGAACTTTAAAGTCTTTGACAATAGTAAACTTGTAGCAGAATATGCTGCTGATATTATTAGAAAGCAATTTAA
CAATAATCCTACTACAATTGCAGGTTTTCATTTAGATACTGATCAAGCGCCAGTACTAGATGAATTAAAGAAAAATATTG
AAAAACATGCTGTTGATTTTAGCCAAATAAATATTTTAGATTATGACGATAAAAAATCATATTTCGAAGCGTTAGGTGTA
CCAGCAGGTCAAGTTTATCCAATTGCTTATGAAAAAGATGCAATCGAATTAATCGCTGATAAGATTAAAACTAAAGAAAA
TAAAGGGAAATTAACATTACAAGTTGTTTCTATCGATGAGCAAGGTAAGTTAAATGTTAGTATTCGTCAAGGACTAATGG
AAGCAAGAGAAATTTTCTTAGTAGTGACTGGTGCTAATAAACGAGATGTAGTTGAAAAATTATATCAAGAAAATGGTAAA
ACAAGCTTCGAACCAGCCGATTTAAAAGCACATAGAATGGTAAATGTTATTCTTGATAAAGAAGCGGCTGCAGGTTTACC
TGAAGATGTTAAAGCTTACTTTACGTCACGCTTTGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E1CEC8

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GXD8

References