Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 874332..874989 Replicon chromosome
Accession NZ_CP090626
Organism Klebsiella pneumoniae isolate KpBO_TO3

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag L0104_RS04405 Protein ID WP_002916310.1
Coordinates 874579..874989 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag L0104_RS04400 Protein ID WP_002916312.1
Coordinates 874332..874598 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L0104_RS04375 (L0104_04375) 869488..870921 - 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -
L0104_RS04380 (L0104_04380) 871040..871768 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
L0104_RS04385 (L0104_04385) 871818..872129 + 312 WP_002916319.1 N(4)-acetylcytidine aminohydrolase -
L0104_RS04390 (L0104_04390) 872293..872952 + 660 WP_002916317.1 hemolysin III family protein -
L0104_RS04395 (L0104_04395) 873103..874086 - 984 WP_002916313.1 tRNA-modifying protein YgfZ -
L0104_RS04400 (L0104_04400) 874332..874598 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
L0104_RS04405 (L0104_04405) 874579..874989 + 411 WP_002916310.1 protein YgfX Toxin
L0104_RS04410 (L0104_04410) 874996..875517 - 522 WP_002916308.1 flavodoxin FldB -
L0104_RS04415 (L0104_04415) 875618..876514 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
L0104_RS04420 (L0104_04420) 876537..877250 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
L0104_RS04425 (L0104_04425) 877256..878989 + 1734 WP_004151783.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T231491 WP_002916310.1 NZ_CP090626:874579-874989 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T231491 NZ_CP126627:c2488558-2488316 [Staphylococcus aureus]
ATGAGCAATTACACGGTTAAGATTAAAAATTCGGCGAAGTTAGATTTAAAGAAGACATTTATAGAAATTGTTGAGACTTT
AAAAAATAATCCTTATAAAATAACACAATCCTTTGAAAAATTAGAACCTAAATATTTAGAGCGATATTCAAGAAGAATTA
ACCTTCAGCACAGGGTCGTCTATACCATAGATGATCGAAATAAAGTAGTATTAATACTATCGGCATGGTCACATTATGAT
TAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT231491 WP_002916312.1 NZ_CP090626:874332-874598 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT231491 NZ_CP126627:c2488815-2488558 [Staphylococcus aureus]
ATGATTATCACTAGCCCTACAGAAGCGAGAAAAGATTTTTATCAATTACTAAAAAATGTTAATAATAATCACGAACCAAT
TTATATTAGTGGTAATAATGCCGAAAATAATGCTGTGATTATAGGTTTAGAAGATTGGAAAAGTATACAAGAGACAATGT
ATCTTGTATCTACTGGTACAATGGACAAAGTAAGAGAAAGAGAAAAAGATAATAGTGGTACAACAAATATAGATGATATT
GATTGGGATAATCTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References