Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4165237..4165856 Replicon chromosome
Accession NZ_CP090623
Organism Klebsiella pneumoniae isolate KpBO_TO5

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag L0103_RS20905 Protein ID WP_002892050.1
Coordinates 4165638..4165856 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag L0103_RS20900 Protein ID WP_002892066.1
Coordinates 4165237..4165611 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L0103_RS20890 (L0103_20890) 4160389..4161582 + 1194 WP_002892072.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
L0103_RS20895 (L0103_20895) 4161605..4164751 + 3147 WP_234859574.1 multidrug efflux RND transporter permease subunit AcrB -
L0103_RS20900 (L0103_20900) 4165237..4165611 + 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
L0103_RS20905 (L0103_20905) 4165638..4165856 + 219 WP_002892050.1 HHA domain-containing protein Toxin
L0103_RS20910 (L0103_20910) 4166015..4166581 + 567 WP_002892030.1 maltose O-acetyltransferase -
L0103_RS20915 (L0103_20915) 4166553..4166693 - 141 WP_004147370.1 hypothetical protein -
L0103_RS20920 (L0103_20920) 4166714..4167184 + 471 WP_002892026.1 YlaC family protein -
L0103_RS20925 (L0103_20925) 4167159..4168610 - 1452 WP_002892023.1 PLP-dependent aminotransferase family protein -
L0103_RS20930 (L0103_20930) 4168711..4169409 + 699 WP_002892021.1 GNAT family protein -
L0103_RS20935 (L0103_20935) 4169406..4169546 - 141 WP_002892018.1 type B 50S ribosomal protein L36 -
L0103_RS20940 (L0103_20940) 4169546..4169809 - 264 WP_002892011.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T231482 WP_002892050.1 NZ_CP090623:4165638-4165856 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T231482 NZ_CP126568:c2790467-2789616 [Xanthomonas oryzae pv. oryzicola]
ATGAGCAACGTCGCCGCTTCCGTGCGCGCCCGCCTGCGGGGCGTCGCCAAGGCGCAGGGCGTGGATTTCAATCAGGTGCT
GGTGCGCTTCGCGCTGGAGCGCATCCTTTACCGCCTGAGCCAGTCCGAGCACGCGGATCGTTTCCTGCTCAAGGGCGCGC
TGCTGTTCACGCTCTGGTATGACATGCCGCACCGGGCCACGCGCGACGCCGACCTGCTGGGCTTCGGCGCGAGCGATCTG
GAGTCCGTGGCCCAGACCTTCCGCGACATCGCCAGCGTCGCCGTGGACGACGGCATCGTGTTCGACCCGGCCTCGGTCGT
CGCAGAAGAAATTCGCAAGGACGCCGGATACGCCGGGGCGCGCATCCTCATCGGCGGCGAGCTGGCCAAGGCGCGGTGCA
GGACGCAGATCGACGTTGGCTTCGGCGATGCGGTCACACCGGCTCCGGTGCACTCGGTCTATCCGGTGTTGCTGGAAGAT
CTGCCTGCGCCTCGCCTGCGCACCTATCCCGTCTACACCGTCATCGCGGAAAAGCTCCACGCCATCGCGCTTCTGGGTAT
GACCAACAGTCGGATGAAGGATTACCTCGACCTGTCGGTGCTGCTGGAACGCGAATCCCTGGACATCGATCTGCTGGCGC
AAGCGGTGAAGGCCACTTTCGAGCGACGCGGCATGGCCGTGCCCGCTGCTCTGCCGATCGGCATGACCGACGAGTTCGCG
CACGACACGTCTCGGCAGGCGTTGTGGCAGGCATTCCTCAAGAAGAACGAACTCGCCCCCGAACCCCTGGCTGCCATCGT
GGTTCGACTGCGGGCGGCCTTGGAACCAGCGTTGCACCGGGCTGCTCGATGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT231482 WP_002892066.1 NZ_CP090623:4165237-4165611 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT231482 NZ_CP126568:c2791069-2790464 [Xanthomonas oryzae pv. oryzicola]
ATGCTTTCCGACACCCACACCCAGCGCGTCCTCGATCTGGCCAGCCAGAAAGGACTGCTGCGCGCCAGCGATCTGGACGC
CATCAATGCGCCCCGGGTCGTTCTCACGCGCCTGACCGCTGCTGGCGTTCTGGAAAGGGTCGGACGCGGGCTGTACCGCC
TGCCGGACGCGCAGGGATCGGAATTCGAGAGTCTCGCGGCCATCGCCACCAAGGTGCCACAAGCCGTGTTCTGCCTGCTG
ACTGCGCTGCAGTTCCACGAACTGACCACGCAACTGCCGCGCCAGATCTGGATCGCCATGCCGCGCGGCAGTCACGCGCC
CCGGATCGGCTATCCGCCGGTCAAGATGGTTCAGATGACCGGCGACGTCTACGCTGCAGGCATCGAGGAGCACCTGCGCG
ACGGCGTGAGGCTGCGCGTGTACGGTGCGGCCAAGACGGTCGTGGACTGCTTCAAGCACCGCAACAAGATCGGCCTGGAC
GTGGCGCTGGAGGCGCTGAAGGACGTGCGCGCCAAACGCAAGGCCACTGCGGACGACCTGTGGCGCTTTGCTACGGTCTG
CCGCGTGGCCAACGTGATGCGCCCCTATCTGGAGGCGGTCGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References