Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4756339..4756855 Replicon chromosome
Accession NZ_CP090622
Organism Klebsiella pneumoniae strain KP19-3138

Toxin (Protein)


Gene name relE Uniprot ID R4YAY3
Locus tag LXT11_RS25920 Protein ID WP_004178374.1
Coordinates 4756339..4756623 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag LXT11_RS25925 Protein ID WP_002886901.1
Coordinates 4756613..4756855 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LXT11_RS25895 (4751734) 4751734..4751997 - 264 WP_014908078.1 PTS sugar transporter subunit IIB -
LXT11_RS25900 (4752127) 4752127..4752300 + 174 WP_032412860.1 hypothetical protein -
LXT11_RS25905 (4752303) 4752303..4753046 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
LXT11_RS25910 (4753403) 4753403..4755541 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
LXT11_RS25915 (4755871) 4755871..4756335 + 465 WP_004178375.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
LXT11_RS25920 (4756339) 4756339..4756623 - 285 WP_004178374.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LXT11_RS25925 (4756613) 4756613..4756855 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
LXT11_RS25930 (4756933) 4756933..4758843 - 1911 WP_004152270.1 PRD domain-containing protein -
LXT11_RS25935 (4758866) 4758866..4760020 - 1155 WP_002886900.1 lactonase family protein -
LXT11_RS25940 (4760087) 4760087..4760827 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11155.97 Da        Isoelectric Point: 10.3787

>T231466 WP_004178374.1 NZ_CP090622:c4756623-4756339 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T231466 NZ_CP126536:c4959567-4959208 [Citrobacter freundii]
ATGACGAAACCACTTTACTGGGTTGGGCAGGCCAGAAAAGACTTGCTTGCAATGCCAGAACACGTTCGGGATACGTTTGG
GTTTGCTTTTTGGCTTGCGCAGCAGGGTAAACAGCATTCACAGACTAAACCATTAAAAGGATTTGGTGGAGCAGGGGTTC
TGGAGGTCGTTGAGGATTACCACGGTAGCGCCTGGCGGGCGGTTTACACCATCCAGTTGAAAAATGCGGTTTATGTTCTC
CATGTTTTTCAGAAGAAATCCGTTTCCGGGAAGGCAACCCCGAAACCTGAAATTGACCTGATTTATCAGCGGCTCAAGGC
TGCACAGCGCCATGCGCAGGAGAGTGGATATGTCATATGA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT231466 WP_002886901.1 NZ_CP090622:c4756855-4756613 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT231466 NZ_CP126536:c4959218-4958901 [Citrobacter freundii]
ATGTCATATGAAGTGGAAGCCAGTAGCGGTAATGTTTACGTCGATTTAGGTGCGTATGACGCAGAACAGATGCAGTTGAA
AGCGCAACTGGCAATGGTGATTGGTGAGATTTTGCAACGCAAAGGGTTAACGCAGCAGCAGGCCGCGCAGCTACTGGGAA
TGACGCAGCCTAAACTTTCCAACCTGTTACGCGGTCAGTTTCGAGGTATCAGTGAAGCAAAGATGCTCGAATGCCTGGTG
AGACTGGGCCGTGATGTAGAGATTGTTGTCGGGAAAGAGGGCAATATGTCAGGAAAGCTGAAAGTGAAATTTGGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A6THG1

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References