Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4041576..4042195 Replicon chromosome
Accession NZ_CP090622
Organism Klebsiella pneumoniae strain KP19-3138

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag LXT11_RS22555 Protein ID WP_002892050.1
Coordinates 4041977..4042195 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag LXT11_RS22550 Protein ID WP_002892066.1
Coordinates 4041576..4041950 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LXT11_RS22540 (4036728) 4036728..4037921 + 1194 WP_004177236.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
LXT11_RS22545 (4037944) 4037944..4041090 + 3147 WP_002892069.1 multidrug efflux RND transporter permease subunit AcrB -
LXT11_RS22550 (4041576) 4041576..4041950 + 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
LXT11_RS22555 (4041977) 4041977..4042195 + 219 WP_002892050.1 HHA domain-containing protein Toxin
LXT11_RS22560 (4042358) 4042358..4042924 + 567 WP_002892030.1 maltose O-acetyltransferase -
LXT11_RS22565 (4042896) 4042896..4043036 - 141 WP_004147370.1 hypothetical protein -
LXT11_RS22570 (4043057) 4043057..4043527 + 471 WP_002892026.1 YlaC family protein -
LXT11_RS22575 (4043502) 4043502..4044953 - 1452 WP_064151794.1 PLP-dependent aminotransferase family protein -
LXT11_RS22580 (4045054) 4045054..4045752 + 699 WP_002892021.1 GNAT family protein -
LXT11_RS22585 (4045749) 4045749..4045889 - 141 WP_002892018.1 type B 50S ribosomal protein L36 -
LXT11_RS22590 (4045889) 4045889..4046152 - 264 WP_002892011.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T231464 WP_002892050.1 NZ_CP090622:4041977-4042195 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T231464 NZ_CP126536:4762836-4763213 [Citrobacter freundii]
ATGAAAACATTACCCGACACACACGTACGGGAGGCATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTGTC
CCGGTTGCTGGACCAGCATTACGGCCTTACGCTGAATGACACACCGTTCGCCGATGAACGTGTGATTGAGCAGCATATTG
AAGCTGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTTGAAAAATACGCACTGGTACGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGTATTGATATTCTCCGGGCTCGCAGGGCAACCGGCCTGATGACCCGCGA
TAACTACAGAACGGTAAATAACATTACCCAGGGGAAGCATCCGGAGGCGAAACAATGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT231464 WP_002892066.1 NZ_CP090622:4041576-4041950 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT231464 NZ_CP126536:4762420-4762746 [Citrobacter freundii]
ATGAGCAACCCTACCAGGGGCCTGCAGCGGGAGATTACACTGCGCCTGGGAGCCCGTCTGGTGCAGGAAGGCAACCGACT
GCATTATCTGGCTGACCGGGCCAGCATCACCGGCAAGTTCAGTGACATCGAATGCCGGAAGCTGGATGAAACATTCCCGC
ACTTTATCCGCCAGATGGAATCGATGCTGACCACCGGTGAACTCAGCCCCCACCATGCCCACTGCGTTACCCTGTACCAC
AACGATTTAACCTGCGAAGCCGACACCTTCGGCTCCTGTGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAACGAA
AAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References