Detailed information of TA system TA231463

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 2669714..2671302
• Replicon: chromosome
• Accession: NZ_CP090622
• Organism: Klebsiella pneumoniae strain KP19-3138

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: -
• Locus tag: LXT11_RS15740
• Protein ID: WP_064151580.1
• Coordinates: 2669714..2671036 (-)
• Length: 441 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: LXT11_RS15745
• Protein ID: WP_004176198.1
• Coordinates: 2671036..2671302 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LXT11_RS15725 (2664770)	2664770..2667271	+	2502	WP_064151582.1	fimbria/pilus outer membrane usher protein	-
LXT11_RS15730 (2667259)	2667259..2668263	+	1005	WP_064151581.1	fimbrial protein	-
LXT11_RS15735 (2668405)	2668405..2669697	+	1293	WP_002904794.1	glycoside hydrolase family 10 protein	-
LXT11_RS15740 (2669714)	2669714..2671036	-	1323	WP_064151580.1	type II toxin-antitoxin system HipA family toxin	Toxin
LXT11_RS15745 (2671036)	2671036..2671302	-	267	WP_004176198.1	type II toxin-antitoxin system antitoxin HipB	Antitoxin
LXT11_RS15750 (2671568)	2671568..2671894	-	327	WP_004176200.1	hydroxyisourate hydrolase	-
LXT11_RS15755 (2671891)	2671891..2672391	-	501	WP_064151579.1	2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase	-
LXT11_RS15760 (2672369)	2672369..2673748	-	1380	WP_004184021.1	nucleobase:cation symporter-2 family protein	-
LXT11_RS15765 (2674094)	2674094..2675248	+	1155	WP_002904783.1	FAD-dependent urate hydroxylase HpxO	-
LXT11_RS15770 (2675229)	2675229..2676152	-	924	WP_008804925.1	LysR family hpxDE operon transcriptional regulator HpxR	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA-like, C-terminal (149-402)

Antitoxin

• Cro/C1-type helix-turn-helix domain (13-65)

Sequences

Toxin

Protein

• Length: 441 a.a.
• Molecular weight: 49152.42 Da
• Isoelectric Point: 7.2850

>T231463 WP_064151580.1 NZ_CP090622:c2671036-2669714 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
AHSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Nucleotide

• Length: 1323 bp

>T231463 NZ_CP126536:c4501716-4501432 [Citrobacter freundii]
ATGACTTATGAACTGGAATTCGACCCGAGAGCCTTAAAAGAGTGGCATAAACTGGGTGATACGGTGAAGGCTCAGTTTAA
GAAGAAGTTGGCCGACGTGTTGTTGAACCCCAGAATTGACTCTGCCCGTTTAAACGGTCTTCCAGATTGCTATAAAATTA
AGCTTAAATCGTCCGGCTATCGTCTGGTGTACCAGGTTCGGGATGAGGTTGTGACCGTGTTTGTTGTCGCGGTCGGCAAA
CGAGAACATTCGGCCGTTTATCTCGATGCAAACAAACGGCTTTAG

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 9936.36 Da
• Isoelectric Point: 8.5912

>AT231463 WP_004176198.1 NZ_CP090622:c2671302-2671036 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMMLNAKAAETAPAP
DNNTDLDW

Nucleotide

• Length: 267 bp

>AT231463 NZ_CP126536:c4501948-4501706 [Citrobacter freundii]
ATGGCCACGCTGAACGTCCGTCTGGATGACAAACTCAAAAATGAGGCTTATGCCGTGCTGGAAAAACTGAACATTACTCC
ATCGGAAGCTGTGCGATTACTGTTTCAGTACGTCGCGGAAACGGGGCGCATGCCAGTGAAAACCGTCACCGTTAGCGACT
GCGAAGATACACTGATTCAGACAGTCCGGGAGAGGCTGGCCAGCCCGCAAAAAGGAATCAAGGTTAGTCTGGATGACTTA
TGA