Detailed information of TA system TA231442

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /DUF1778(antitoxin)
• Location: 394256..395055
• Replicon: chromosome
• Accession: NZ_CP090615
• Organism: Vibrio pelagius strain WXL662

Toxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: LZI70_RS15590
• Protein ID: WP_255232582.1
• Coordinates: 394522..395055 (+)
• Length: 178 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: LZI70_RS15585
• Protein ID: WP_255232581.1
• Coordinates: 394256..394525 (+)
• Length: 90 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LZI70_RS15550 (LZI70_15530)	389435..389689	-	255	WP_255232576.1	HNH endonuclease signature motif containing protein	-
LZI70_RS15555 (LZI70_15535)	390330..391226	+	897	WP_255232577.1	WYL domain-containing protein	-
LZI70_RS15560 (LZI70_15540)	391622..392120	-	499	Protein_347	transposase	-
LZI70_RS15565 (LZI70_15545)	392218..393198	+	981	WP_255232578.1	DUF559 domain-containing protein	-
LZI70_RS15570 (LZI70_15550)	393189..393335	+	147	WP_255232779.1	DUF3265 domain-containing protein	-
LZI70_RS15575 (LZI70_15555)	393324..393614	-	291	WP_255232579.1	type II toxin-antitoxin system RelE/ParE family toxin	-
LZI70_RS15580 (LZI70_15560)	393604..393852	-	249	WP_255232580.1	type II toxin-antitoxin system Phd/YefM family antitoxin	-
LZI70_RS15585 (LZI70_15565)	394256..394525	+	270	WP_255232581.1	DUF1778 domain-containing protein	Antitoxin
LZI70_RS15590 (LZI70_15570)	394522..395055	+	534	WP_255232582.1	GNAT family N-acetyltransferase	Toxin
LZI70_RS15595 (LZI70_15575)	395342..396265	-	924	WP_255232583.1	LysR family transcriptional regulator	-
LZI70_RS15600 (LZI70_15580)	396299..397558	-	1260	WP_255232584.1	hydroxymethylglutaryl-CoA reductase	-
LZI70_RS15605 (LZI70_15585)	397725..398045	-	321	WP_255232585.1	hypothetical protein	-
LZI70_RS15610 (LZI70_15590)	398366..398539	-	174	WP_255232586.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Vibrio phage ICP1, Orf50 (5-81)

Sequences

Toxin

Protein

• Length: 178 a.a.
• Molecular weight: 20191.50 Da
• Isoelectric Point: 9.6165

>T231442 WP_255232582.1 NZ_CP090615:394522-395055 [Vibrio pelagius]
VSWGKEFVELSKSKHDRNSFDCGEQELNTFIKTQAAKHMQAGISRTMVLPSSQPLLNQKFAICAFYSVAPSSISREILPA
QQAKKLPRYPIPVFVLAQLAVHKEFHGSGLGKVSLIRALKYLWEVNRYMRAYAIVVDCLTDSAQAFYAKFDFEVLCEHNG
RIRMFLPMKTVEQLFNQ

Nucleotide

• Length: 534 bp

>T231442 NZ_CP126521:521704-522054 [Bacillus pumilus]
TTGATTGTTAAACGCGGTGATGTTTACTTTGCTGATTTATCTCCTGTTGTTGGCTCCGAGCAGGGCGGGGTTCGCCCGGT
ATTGGTGATTCAGAATGACATTGGAAATCGCTTCAGCCCGACTGCTATCGTTGCAGCCATAACAGCCCAAATACAAAAAG
CGAAATTACCGACTCACGTCGAAATTAATGCAAAGCGGTACGGCTTTGAACGAGATTCTGTCATTCTTTTGGAACAAATT
CGTACAATCGATAAACAAAGACTGACAGATAAAATCACACATCTTGATGATGAGATGATGGAGAAGGTTGATGAAGCCTT
ACAAGTTAGTTTGGCTCTTATTGATTTTTAA

Antitoxin

Protein

• Length: 90 a.a.
• Molecular weight: 9855.30 Da
• Isoelectric Point: 4.5822

>AT231442 WP_255232581.1 NZ_CP090615:394256-394525 [Vibrio pelagius]
MATARLDIRLDEEIKAKAEKASALLGLKSLTEYVVRLMDEDATHVIEEHESIMVKDSVFDEFMAACNKAKAPNQALIEAA
KFTDESGIK

Nucleotide

• Length: 270 bp

>AT231442 NZ_CP126521:521418-521699 [Bacillus pumilus]
TTGTCTGAATCCAGCGCAACAAACGAAATGAAGATTCGACTGCCGGAGACTTTAATGTCTGAGATCGAACGAGTAGCAGA
GCAGGATAAGGTAACAAGAAATGAATTGATCTACCGAGCGACAAAAACGTATATTCGTGAACGTAATATTCGACAAAATC
GTGAATCGATGAGACGCGGCTACATGGAGATGGCGAAAATTAATCTGAATATCTCTTCAGAGGCACAATACGCAGAATTT
GAGGCTGAGAATACAGTTGAGCGATTAGTCAGCGGGGGTTAA