Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | ccdAB/CcdA(antitoxin) |
Location | 3540078..3540610 | Replicon | chromosome |
Accession | NZ_CP090611 | ||
Organism | Escherichia coli isolate DCE7 |
Toxin (Protein)
Gene name | ccdB | Uniprot ID | A0A2A7M2E8 |
Locus tag | LZG50_RS17415 | Protein ID | WP_001160959.1 |
Coordinates | 3540078..3540374 (-) | Length | 99 a.a. |
Antitoxin (Protein)
Gene name | ccdA | Uniprot ID | V0VEX8 |
Locus tag | LZG50_RS17420 | Protein ID | WP_000125566.1 |
Coordinates | 3540377..3540610 (-) | Length | 78 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
LZG50_RS17390 (3535753) | 3535753..3537039 | + | 1287 | WP_000800457.1 | peptidylprolyl isomerase SurA | - |
LZG50_RS17395 (3537039) | 3537039..3538028 | + | 990 | WP_000241229.1 | 4-hydroxythreonine-4-phosphate dehydrogenase PdxA | - |
LZG50_RS17400 (3538025) | 3538025..3538846 | + | 822 | WP_001065367.1 | 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))- dimethyltransferase RsmA | - |
LZG50_RS17405 (3538849) | 3538849..3539226 | + | 378 | WP_000610901.1 | Co2+/Mg2+ efflux protein ApaG | - |
LZG50_RS17410 (3539233) | 3539233..3540081 | + | 849 | WP_000257181.1 | bis(5'-nucleosyl)-tetraphosphatase (symmetrical) ApaH | - |
LZG50_RS17415 (3540078) | 3540078..3540374 | - | 297 | WP_001160959.1 | CcdB family protein | Toxin |
LZG50_RS17420 (3540377) | 3540377..3540610 | - | 234 | WP_000125566.1 | type II toxin-antitoxin system CcdA family antitoxin | Antitoxin |
LZG50_RS17425 (3540696) | 3540696..3541175 | - | 480 | WP_000624375.1 | type 3 dihydrofolate reductase | - |
LZG50_RS17430 (3541367) | 3541367..3543229 | - | 1863 | WP_096891018.1 | glutathione-regulated potassium-efflux system protein KefC | - |
LZG50_RS17435 (3543222) | 3543222..3543752 | - | 531 | WP_000600723.1 | glutathione-regulated potassium-efflux system oxidoreductase KefF | - |
LZG50_RS17440 (3543860) | 3543860..3545191 | - | 1332 | WP_001183198.1 | MFS transporter | - |
LZG50_RS17445 (3545250) | 3545250..3545537 | - | 288 | WP_000203741.1 | ferredoxin-like protein FixX | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 99 a.a. Molecular weight: 11089.98 Da Isoelectric Point: 8.0406
>T231424 WP_001160959.1 NZ_CP090611:c3540374-3540078 [Escherichia coli]
MQFTVYRSRGRNAAFPFVIDVTSDIIGEINRRIVIPFIRIRPPERLNTILLLVDGKEYVLMTHETETVPVNALGTKFCDA
SAHRTLIKGALDFMLDGI
MQFTVYRSRGRNAAFPFVIDVTSDIIGEINRRIVIPFIRIRPPERLNTILLLVDGKEYVLMTHETETVPVNALGTKFCDA
SAHRTLIKGALDFMLDGI
Download Length: 297 bp
>T231424 NZ_CP126348:c4038248-4037898 [Escherichia coli]
ATGGTAAAGAAAAGTGAATTTGAACGGGGAGACATTGTGCTGGTTGGCTTTGATCCAGCAAGCGGCCATGAACAGCAAGG
TGCTGGTCGACCTGCGCTTGTGCTCTCCGTTCAAGCCTTTAATCAACTGGGAATGACGCTGGTGGCCCCCATTACGCAGG
GCGGAAATTTTGCCCGTTATGCCGGATTTAGCGTTCCTTTACATTGCGAAGAAGGCGATGTGCACGGCGTGGTGCTGGTG
AATCAGGTGCGGATGATGGATCTACGCGCCCGGCTGGCAAAGCGTATTGGTCTGGCTGCGGATGAGGTGGTGGAAGAGGC
GTTATTACGCTTGCAGGCGGTGGTGGAATAA
ATGGTAAAGAAAAGTGAATTTGAACGGGGAGACATTGTGCTGGTTGGCTTTGATCCAGCAAGCGGCCATGAACAGCAAGG
TGCTGGTCGACCTGCGCTTGTGCTCTCCGTTCAAGCCTTTAATCAACTGGGAATGACGCTGGTGGCCCCCATTACGCAGG
GCGGAAATTTTGCCCGTTATGCCGGATTTAGCGTTCCTTTACATTGCGAAGAAGGCGATGTGCACGGCGTGGTGCTGGTG
AATCAGGTGCGGATGATGGATCTACGCGCCCGGCTGGCAAAGCGTATTGGTCTGGCTGCGGATGAGGTGGTGGAAGAGGC
GTTATTACGCTTGCAGGCGGTGGTGGAATAA
Antitoxin
Download Length: 78 a.a. Molecular weight: 8530.53 Da Isoelectric Point: 5.8062
>AT231424 WP_000125566.1 NZ_CP090611:c3540610-3540377 [Escherichia coli]
MTAKRTTQSVTVTVDRELVNRARDAGLNMSATLTVALNAELKKHAATRWREENAEAIAALNQLADETGCFSDEYRSF
MTAKRTTQSVTVTVDRELVNRARDAGLNMSATLTVALNAELKKHAATRWREENAEAIAALNQLADETGCFSDEYRSF
Download Length: 234 bp
>AT231424 NZ_CP126348:c4038493-4038242 [Escherichia coli]
ATGCGTATTACCATAAAAAGATGGGGGAACAGTGCAGGTATGGTCATTCCCAATATCGTAATGAAAGAACTTAACTTACA
GCCGGGGCAGAGCGTGGAAGCGCAGGTGAGCAACAACCAACTGATTCTGACACCCATCTCCAGGCGCTACTCGCTTGATG
AACTGCTGGCACAGTGTGACATGAACGCCGCGGAACTTAGCGAGCAGGATGTCTGGGGTAAATCCACCCCTGCGGGTGAC
GAAATATGGTAA
ATGCGTATTACCATAAAAAGATGGGGGAACAGTGCAGGTATGGTCATTCCCAATATCGTAATGAAAGAACTTAACTTACA
GCCGGGGCAGAGCGTGGAAGCGCAGGTGAGCAACAACCAACTGATTCTGACACCCATCTCCAGGCGCTACTCGCTTGATG
AACTGCTGGCACAGTGTGACATGAACGCCGCGGAACTTAGCGAGCAGGATGTCTGGGGTAAATCCACCCCTGCGGGTGAC
GAAATATGGTAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A2A7M2E8 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A7U9LTM9 |