Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | Hha-TomB/- |
Location | 3097368..3097986 | Replicon | chromosome |
Accession | NZ_CP090611 | ||
Organism | Escherichia coli isolate DCE7 |
Toxin (Protein)
Gene name | Hha | Uniprot ID | H5UYE2 |
Locus tag | LZG50_RS15310 | Protein ID | WP_001291435.1 |
Coordinates | 3097768..3097986 (+) | Length | 73 a.a. |
Antitoxin (Protein)
Gene name | TomB | Uniprot ID | S1PTH5 |
Locus tag | LZG50_RS15305 | Protein ID | WP_000344800.1 |
Coordinates | 3097368..3097742 (+) | Length | 125 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
LZG50_RS15295 (3092459) | 3092459..3093652 | + | 1194 | WP_001295833.1 | multidrug efflux RND transporter periplasmic adaptor subunit AcrA | - |
LZG50_RS15300 (3093675) | 3093675..3096824 | + | 3150 | WP_001132480.1 | efflux RND transporter permease AcrB | - |
LZG50_RS15305 (3097368) | 3097368..3097742 | + | 375 | WP_000344800.1 | Hha toxicity modulator TomB | Antitoxin |
LZG50_RS15310 (3097768) | 3097768..3097986 | + | 219 | WP_001291435.1 | HHA domain-containing protein | Toxin |
LZG50_RS15315 (3098160) | 3098160..3098711 | + | 552 | WP_000102539.1 | maltose O-acetyltransferase | - |
LZG50_RS15320 (3098827) | 3098827..3099297 | + | 471 | WP_000136192.1 | YlaC family protein | - |
LZG50_RS15325 (3099461) | 3099461..3101011 | + | 1551 | WP_014640107.1 | cyclic-guanylate-specific phosphodiesterase PdeB | - |
LZG50_RS15330 (3101053) | 3101053..3101406 | - | 354 | WP_000878140.1 | DUF1428 domain-containing protein | - |
LZG50_RS15340 (3101785) | 3101785..3102096 | + | 312 | WP_000409908.1 | MGMT family protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | flank | IS/Tn | - | - | 3102122..3103495 | 1373 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 73 a.a. Molecular weight: 8628.00 Da Isoelectric Point: 8.9008
>T231423 WP_001291435.1 NZ_CP090611:3097768-3097986 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR
Download Length: 219 bp
>T231423 NZ_CP126348:c3966504-3966163 [Escherichia coli]
ATGAAACCTCAACCTGCAACAACTTCGCGGGCGGTAAAGCCTTGTCTGTCGCCCGTGGCAGTCTGGCAAATGTTACTGAC
ACGCCTGCTGGAACAGCACTATGGCCTGACGCTAAACGACACGCCGTTCAGTGATGAAACTGTGATTAAGGAACATATCG
ATGCCGGTATCACGCTGGCTGATGCCGTGAATTTTCTGGTGGAAAAATATGAACTAGTTCGTATCGATCGCAGAGGGTTT
AACTGGCAGGAGCAATCACCTTATCTTCGCGCGGTAGATATACTGCGAGCACGACGGGCGATTGGTTTATTGCGACGAAG
TCTTAATGATGCTGTATTGTGA
ATGAAACCTCAACCTGCAACAACTTCGCGGGCGGTAAAGCCTTGTCTGTCGCCCGTGGCAGTCTGGCAAATGTTACTGAC
ACGCCTGCTGGAACAGCACTATGGCCTGACGCTAAACGACACGCCGTTCAGTGATGAAACTGTGATTAAGGAACATATCG
ATGCCGGTATCACGCTGGCTGATGCCGTGAATTTTCTGGTGGAAAAATATGAACTAGTTCGTATCGATCGCAGAGGGTTT
AACTGGCAGGAGCAATCACCTTATCTTCGCGCGGTAGATATACTGCGAGCACGACGGGCGATTGGTTTATTGCGACGAAG
TCTTAATGATGCTGTATTGTGA
Antitoxin
Download Length: 125 a.a. Molecular weight: 14557.39 Da Isoelectric Point: 4.7395
>AT231423 WP_000344800.1 NZ_CP090611:3097368-3097742 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC
Download Length: 375 bp
>AT231423 NZ_CP126348:c3966842-3966525 [Escherichia coli]
ATGAGCAACATCACATGGGGCCTGCAGCGGGATATCACGCCACACCTGGGAGCCCGTCTGGTGCAGGAGGGTAACCGGCT
GCATTATTTGGCTGACCGGGCCAGCATCATCGGTAAGTTCAGTGGCGCCGAATGCCGGAAGCTGGATGAAATATTCCCGC
ACTTTATCAGCCAGATGGAATCCATGCTGACCACGGGAGAACTGAATCCCCGTTACACCCACTGTATTACCCTGTATCAC
AATGGTTTTACCTGCGAAGCCGATACCCTTGGCAGTTGCGGCTACGTATACATCGCCATTTACCCCAATCAGCATTAA
ATGAGCAACATCACATGGGGCCTGCAGCGGGATATCACGCCACACCTGGGAGCCCGTCTGGTGCAGGAGGGTAACCGGCT
GCATTATTTGGCTGACCGGGCCAGCATCATCGGTAAGTTCAGTGGCGCCGAATGCCGGAAGCTGGATGAAATATTCCCGC
ACTTTATCAGCCAGATGGAATCCATGCTGACCACGGGAGAACTGAATCCCCGTTACACCCACTGTATTACCCTGTATCAC
AATGGTTTTACCTGCGAAGCCGATACCCTTGGCAGTTGCGGCTACGTATACATCGCCATTTACCCCAATCAGCATTAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
PDB | 2MW2 | |
PDB | 1JW2 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A7U9QBQ5 |