Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | paaR-paaA-parE/- |
Location | 2352153..2352634 | Replicon | chromosome |
Accession | NZ_CP090611 | ||
Organism | Escherichia coli isolate DCE7 |
Toxin (Protein)
Gene name | parE_1 | Uniprot ID | A0A0D7YS45 |
Locus tag | LZG50_RS11580 | Protein ID | WP_014966210.1 |
Coordinates | 2352344..2352634 (+) | Length | 97 a.a. |
Antitoxin (Protein)
Gene name | paaA | Uniprot ID | A0A0D7Y007 |
Locus tag | LZG50_RS11575 | Protein ID | WP_000100896.1 |
Coordinates | 2352153..2352344 (+) | Length | 64 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
LZG50_RS11525 (2347225) | 2347225..2347488 | - | 264 | WP_000224233.1 | hypothetical protein | - |
LZG50_RS11530 (2347490) | 2347490..2347708 | - | 219 | WP_000209148.1 | DUF4014 family protein | - |
LZG50_RS11535 (2347741) | 2347741..2347953 | - | 213 | WP_000935424.1 | hypothetical protein | - |
LZG50_RS11540 (2348059) | 2348059..2348481 | - | 423 | WP_032241101.1 | DUF977 family protein | - |
LZG50_RS11545 (2348497) | 2348497..2349267 | - | 771 | WP_000450649.1 | DUF1627 domain-containing protein | - |
LZG50_RS11550 (2349301) | 2349301..2349762 | - | 462 | WP_000139447.1 | replication protein P | - |
LZG50_RS11555 (2349755) | 2349755..2350771 | - | 1017 | WP_001262344.1 | DnaT-like ssDNA-binding domain-containing protein | - |
LZG50_RS11560 (2350843) | 2350843..2351268 | - | 426 | WP_000693918.1 | toxin YdaT family protein | - |
LZG50_RS11565 (2351252) | 2351252..2351527 | - | 276 | WP_001048458.1 | helix-turn-helix transcriptional regulator | - |
LZG50_RS11570 (2351635) | 2351635..2352135 | + | 501 | WP_234732849.1 | helix-turn-helix transcriptional regulator | - |
LZG50_RS11575 (2352153) | 2352153..2352344 | + | 192 | WP_000100896.1 | hypothetical protein | Antitoxin |
LZG50_RS11580 (2352344) | 2352344..2352634 | + | 291 | WP_014966210.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
LZG50_RS11585 (2352904) | 2352904..2353059 | + | 156 | WP_000379575.1 | DUF1391 family protein | - |
LZG50_RS24590 (2353061) | 2353061..2353189 | + | 129 | WP_000344964.1 | protein YdfB | - |
LZG50_RS11590 (2353219) | 2353219..2353437 | + | 219 | WP_001171974.1 | protein YdfC | - |
LZG50_RS11595 (2354006) | 2354006..2354194 | + | 189 | WP_000449192.1 | cell division inhibition protein DicB | - |
LZG50_RS11600 (2354191) | 2354191..2354382 | + | 192 | WP_001090200.1 | DUF1482 family protein | - |
LZG50_RS11605 (2354475) | 2354475..2356946 | + | 2472 | WP_234732850.1 | exonuclease | - |
LZG50_RS11610 (2357008) | 2357008..2357277 | + | 270 | WP_000003742.1 | excisionase | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Prophage | - | - | 2312921..2365532 | 52611 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 97 a.a. Molecular weight: 11176.05 Da Isoelectric Point: 9.9854
>T231421 WP_014966210.1 NZ_CP090611:2352344-2352634 [Escherichia coli]
MLPILWLPSARDDLRQIVAYIAKENPPAARRLKIRIETSVLSLTEHPYLYPPSERVPSLREIVTHPNYIILYRVTASNIE
IVNVVHSRRQYPNKTC
MLPILWLPSARDDLRQIVAYIAKENPPAARRLKIRIETSVLSLTEHPYLYPPSERVPSLREIVTHPNYIILYRVTASNIE
IVNVVHSRRQYPNKTC
Download Length: 291 bp
>T231421 NZ_CP126348:3391061-3391603 [Escherichia coli]
ATGGTCGACAAGCATGAAGAGATTACTCTGCCCATAGTCCTCTCCTGTAATTATCAGTCTGATATTACTTATCCTGGGCA
AAAACAGTTTGATTGCGGTAACCCTGTTATCGATAAATTTGTACGCGCATCGCTAAAGAAAAGTGTGCGTAATAGCGACT
GTGCGGCTAAAGCACTTATTGACAGACAAAGTGGTGAACTGATCGGCATCTGTACTTTTACGGCATATTCGCTGGAAAAA
CAACGCGTTTCTGGCGTCCTTCAGGGTTCACAACCTTCAGAAATTGGTGTTGTCAGATTAGTCATGTTGGGGGTAGCACG
GAAGTATCAAAAGCGGGGCTTTGGTCAGGACCTACTATGTGATTTTTTTGAACATGTAAAAATAATTCACCAGGCATTAC
CAATTAAAGGGGTTTATCTTGATGCTGACCCTGCCGCCATTAATTTTTATGCTCGTCTCGGCTTTGTTCAGCTTTCAGCG
ACACCAAATGCTTTTGGTGCTGTACCTATGTTTTTGGCGATTCAGCATATTCTCGCGGCTTAG
ATGGTCGACAAGCATGAAGAGATTACTCTGCCCATAGTCCTCTCCTGTAATTATCAGTCTGATATTACTTATCCTGGGCA
AAAACAGTTTGATTGCGGTAACCCTGTTATCGATAAATTTGTACGCGCATCGCTAAAGAAAAGTGTGCGTAATAGCGACT
GTGCGGCTAAAGCACTTATTGACAGACAAAGTGGTGAACTGATCGGCATCTGTACTTTTACGGCATATTCGCTGGAAAAA
CAACGCGTTTCTGGCGTCCTTCAGGGTTCACAACCTTCAGAAATTGGTGTTGTCAGATTAGTCATGTTGGGGGTAGCACG
GAAGTATCAAAAGCGGGGCTTTGGTCAGGACCTACTATGTGATTTTTTTGAACATGTAAAAATAATTCACCAGGCATTAC
CAATTAAAGGGGTTTATCTTGATGCTGACCCTGCCGCCATTAATTTTTATGCTCGTCTCGGCTTTGTTCAGCTTTCAGCG
ACACCAAATGCTTTTGGTGCTGTACCTATGTTTTTGGCGATTCAGCATATTCTCGCGGCTTAG
Antitoxin
Download Length: 64 a.a. Molecular weight: 7033.83 Da Isoelectric Point: 4.0270
>AT231421 WP_000100896.1 NZ_CP090611:2352153-2352344 [Escherichia coli]
MSTALSPIISEFETVEQENSYNEWLRTKVAASLSDPRPAIPHDEVMAEMENLIAQLAATNRSE
MSTALSPIISEFETVEQENSYNEWLRTKVAASLSDPRPAIPHDEVMAEMENLIAQLAATNRSE
Download Length: 192 bp
>AT231421 NZ_CP126348:3390766-3391077 [Escherichia coli]
ATGCCTGGAAAAACAGCCACTCTACCCGATGTCGATAAAACGCTGAAAAATGCGCGGGTCGAACTCAAAACTAGTCCCGA
CGCCAAAAACAAACTTCGTGAAGCTGCGCAAGCCGTTGGGGTAGATTTAAGCGCTTTTATTTTGAGCGCTGCTATGGAAC
GCGCCGAAAGTGTGCTTGATAACCAACGTCGCCGTGAGCTTTCGAATCAAAGCTGGGAACTGATGAACCAACTCATCGCT
GAACCTGCTCAACCGACGCTCGCCCTCAAGGCGTTAATGAAAAGGAAAAACAGCGATGGTCGACAAGCATGA
ATGCCTGGAAAAACAGCCACTCTACCCGATGTCGATAAAACGCTGAAAAATGCGCGGGTCGAACTCAAAACTAGTCCCGA
CGCCAAAAACAAACTTCGTGAAGCTGCGCAAGCCGTTGGGGTAGATTTAAGCGCTTTTATTTTGAGCGCTGCTATGGAAC
GCGCCGAAAGTGTGCTTGATAACCAACGTCGCCGTGAGCTTTCGAATCAAAGCTGGGAACTGATGAACCAACTCATCGCT
GAACCTGCTCAACCGACGCTCGCCCTCAAGGCGTTAATGAAAAGGAAAAACAGCGATGGTCGACAAGCATGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A0D7YS45 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A0D7Y007 |