Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) paaR-paaA-parE/-
Location 2352153..2352634 Replicon chromosome
Accession NZ_CP090611
Organism Escherichia coli isolate DCE7

Toxin (Protein)


Gene name parE_1 Uniprot ID A0A0D7YS45
Locus tag LZG50_RS11580 Protein ID WP_014966210.1
Coordinates 2352344..2352634 (+) Length 97 a.a.

Antitoxin (Protein)


Gene name paaA Uniprot ID A0A0D7Y007
Locus tag LZG50_RS11575 Protein ID WP_000100896.1
Coordinates 2352153..2352344 (+) Length 64 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LZG50_RS11525 (2347225) 2347225..2347488 - 264 WP_000224233.1 hypothetical protein -
LZG50_RS11530 (2347490) 2347490..2347708 - 219 WP_000209148.1 DUF4014 family protein -
LZG50_RS11535 (2347741) 2347741..2347953 - 213 WP_000935424.1 hypothetical protein -
LZG50_RS11540 (2348059) 2348059..2348481 - 423 WP_032241101.1 DUF977 family protein -
LZG50_RS11545 (2348497) 2348497..2349267 - 771 WP_000450649.1 DUF1627 domain-containing protein -
LZG50_RS11550 (2349301) 2349301..2349762 - 462 WP_000139447.1 replication protein P -
LZG50_RS11555 (2349755) 2349755..2350771 - 1017 WP_001262344.1 DnaT-like ssDNA-binding domain-containing protein -
LZG50_RS11560 (2350843) 2350843..2351268 - 426 WP_000693918.1 toxin YdaT family protein -
LZG50_RS11565 (2351252) 2351252..2351527 - 276 WP_001048458.1 helix-turn-helix transcriptional regulator -
LZG50_RS11570 (2351635) 2351635..2352135 + 501 WP_234732849.1 helix-turn-helix transcriptional regulator -
LZG50_RS11575 (2352153) 2352153..2352344 + 192 WP_000100896.1 hypothetical protein Antitoxin
LZG50_RS11580 (2352344) 2352344..2352634 + 291 WP_014966210.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LZG50_RS11585 (2352904) 2352904..2353059 + 156 WP_000379575.1 DUF1391 family protein -
LZG50_RS24590 (2353061) 2353061..2353189 + 129 WP_000344964.1 protein YdfB -
LZG50_RS11590 (2353219) 2353219..2353437 + 219 WP_001171974.1 protein YdfC -
LZG50_RS11595 (2354006) 2354006..2354194 + 189 WP_000449192.1 cell division inhibition protein DicB -
LZG50_RS11600 (2354191) 2354191..2354382 + 192 WP_001090200.1 DUF1482 family protein -
LZG50_RS11605 (2354475) 2354475..2356946 + 2472 WP_234732850.1 exonuclease -
LZG50_RS11610 (2357008) 2357008..2357277 + 270 WP_000003742.1 excisionase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2312921..2365532 52611


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11176.05 Da        Isoelectric Point: 9.9854

>T231421 WP_014966210.1 NZ_CP090611:2352344-2352634 [Escherichia coli]
MLPILWLPSARDDLRQIVAYIAKENPPAARRLKIRIETSVLSLTEHPYLYPPSERVPSLREIVTHPNYIILYRVTASNIE
IVNVVHSRRQYPNKTC

Download         Length: 291 bp

>T231421 NZ_CP126348:3391061-3391603 [Escherichia coli]
ATGGTCGACAAGCATGAAGAGATTACTCTGCCCATAGTCCTCTCCTGTAATTATCAGTCTGATATTACTTATCCTGGGCA
AAAACAGTTTGATTGCGGTAACCCTGTTATCGATAAATTTGTACGCGCATCGCTAAAGAAAAGTGTGCGTAATAGCGACT
GTGCGGCTAAAGCACTTATTGACAGACAAAGTGGTGAACTGATCGGCATCTGTACTTTTACGGCATATTCGCTGGAAAAA
CAACGCGTTTCTGGCGTCCTTCAGGGTTCACAACCTTCAGAAATTGGTGTTGTCAGATTAGTCATGTTGGGGGTAGCACG
GAAGTATCAAAAGCGGGGCTTTGGTCAGGACCTACTATGTGATTTTTTTGAACATGTAAAAATAATTCACCAGGCATTAC
CAATTAAAGGGGTTTATCTTGATGCTGACCCTGCCGCCATTAATTTTTATGCTCGTCTCGGCTTTGTTCAGCTTTCAGCG
ACACCAAATGCTTTTGGTGCTGTACCTATGTTTTTGGCGATTCAGCATATTCTCGCGGCTTAG

Antitoxin


Download         Length: 64 a.a.        Molecular weight: 7033.83 Da        Isoelectric Point: 4.0270

>AT231421 WP_000100896.1 NZ_CP090611:2352153-2352344 [Escherichia coli]
MSTALSPIISEFETVEQENSYNEWLRTKVAASLSDPRPAIPHDEVMAEMENLIAQLAATNRSE

Download         Length: 192 bp

>AT231421 NZ_CP126348:3390766-3391077 [Escherichia coli]
ATGCCTGGAAAAACAGCCACTCTACCCGATGTCGATAAAACGCTGAAAAATGCGCGGGTCGAACTCAAAACTAGTCCCGA
CGCCAAAAACAAACTTCGTGAAGCTGCGCAAGCCGTTGGGGTAGATTTAAGCGCTTTTATTTTGAGCGCTGCTATGGAAC
GCGCCGAAAGTGTGCTTGATAACCAACGTCGCCGTGAGCTTTCGAATCAAAGCTGGGAACTGATGAACCAACTCATCGCT
GAACCTGCTCAACCGACGCTCGCCCTCAAGGCGTTAATGAAAAGGAAAAACAGCGATGGTCGACAAGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0D7YS45

Antitoxin

Source ID Structure
AlphaFold DB A0A0D7Y007

References