Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 1182979..1183565 Replicon chromosome
Accession NZ_CP090610
Organism Burkholderia cepacia strain CMCC(B)23005

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag LZ568_RS38970 Protein ID WP_234743364.1
Coordinates 1183182..1183565 (+) Length 128 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag LZ568_RS38965 Protein ID WP_234743363.1
Coordinates 1182979..1183185 (+) Length 69 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LZ568_RS38940 (LZ568_38940) 1178297..1179130 - 834 WP_212103873.1 DUF1295 domain-containing protein -
LZ568_RS38945 (LZ568_38945) 1179282..1180016 - 735 WP_059676247.1 anti-sigma factor -
LZ568_RS38950 (LZ568_38950) 1180013..1180624 - 612 WP_034203526.1 sigma-70 family RNA polymerase sigma factor -
LZ568_RS38955 (LZ568_38955) 1180875..1181444 + 570 WP_212103891.1 lipocalin family protein -
LZ568_RS38960 (LZ568_38960) 1181735..1182394 - 660 WP_059676244.1 carbonic anhydrase -
LZ568_RS38965 (LZ568_38965) 1182979..1183185 + 207 WP_234743363.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
LZ568_RS38970 (LZ568_38970) 1183182..1183565 + 384 WP_234743364.1 PIN domain-containing protein Toxin
LZ568_RS38975 (LZ568_38975) 1183609..1183860 + 252 WP_234743365.1 hypothetical protein -
LZ568_RS38980 (LZ568_38980) 1183857..1184060 - 204 Protein_1072 transposase domain-containing protein -
LZ568_RS38985 (LZ568_38985) 1184678..1185550 - 873 WP_027792660.1 slipin family protein -
LZ568_RS38990 (LZ568_38990) 1185878..1186330 + 453 WP_234743366.1 type II toxin-antitoxin system HicB family antitoxin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-114)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 14289.65 Da        Isoelectric Point: 7.7835

>T231411 WP_234743364.1 NZ_CP090610:1183182-1183565 [Burkholderia cepacia]
MSVLVDTSVWVEHFRRPLPALIQLLRVDSILTHPLVILELTCGTPPEPRARTLGDLALLRQTRLATPGEVADWIERERLY
GRGCGAVDCTLLASVLLTPSTRLWTRDRRLAQLAERFGAQYVPPDLH

Download         Length: 384 bp

>T231411 NZ_CP126348:1095351-1095662 [Escherichia coli]
ATGCACATCATTTCTAAAGCGCCATTTGAAGAGTCTGCGCGTAAATATCCTAACGACGCTCTGGCTCATCAGGCATTGTA
TCGGGTTATTAAGGAAACGGATTTTTCTACACCAGAAGAAATGCGAACGGCGTTTCCCAACCTCGACAATTTTAGATATC
GCAACAAATGGTACGTTCTGGATGTCGGCGGGAACAATCTTAGGGTTATTGCCTACATAAACTTTGTTAATAAGCGGTTC
TTTGTGAAGCACATAACGAATCACGCAGAGTATGACAAACTGACACGTTACTACAGAGAGAACAAAGAATGA

Antitoxin


Download         Length: 69 a.a.        Molecular weight: 7297.36 Da        Isoelectric Point: 6.2465

>AT231411 WP_234743363.1 NZ_CP090610:1182979-1183185 [Burkholderia cepacia]
MRTTVTVDDTLYARALELAEPGMPPADLFRAALETFVRVQAGQRLAALGGRAPDMADVPRRAAEATAR

Download         Length: 207 bp

>AT231411 NZ_CP126348:1095659-1096078 [Escherichia coli]
ATGACTGCTAATGCTGCACGCGCTGTTAAAGCAACAAGAGAACTGGTCAATGCAGTCCCCTTTCTGGGAGGCAGTGACTC
AGAAGATGATTATCGTGAAGCACTGGAACTGGTCGAATATTTGATTGAAGAAGATGACACCAATCCACTTATCGACTTTC
TGGCGAGCCGCATTGCAGAGTATGAAAACAACAACGAAAAGTTTGCAGAGTTCGACAAAGCCGTTGCGGCAATGCCGGTT
GGCGTGGCGTTACTTCGCACGTTGATTGATCAACATAATCTGACCTATGCGGATTTGAAGAACGAAATCGGCTCTAAATC
CCTGGTCAGTCAGATTTTGTCTGGACAACGATCCCTGACAATATCCCACATTAAGGCACTTTCAGCCCGATTTGGCGTTA
AGCCGGAATGGTTTCTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References