Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | phd-doc/HTH_IclR(antitoxin) |
| Location | 3200143..3201893 | Replicon | chromosome |
| Accession | NZ_CP090609 | ||
| Organism | Burkholderia cepacia strain CMCC(B)23005 | ||
Toxin (Protein)
| Gene name | doc | Uniprot ID | - |
| Locus tag | LZ568_RS32375 | Protein ID | WP_059697599.1 |
| Coordinates | 3200143..3201039 (+) | Length | 299 a.a. |
Antitoxin (Protein)
| Gene name | phd | Uniprot ID | A0A4S5DGT0 |
| Locus tag | LZ568_RS32380 | Protein ID | WP_027789379.1 |
| Coordinates | 3201036..3201893 (+) | Length | 286 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LZ568_RS32345 (LZ568_32345) | 3195519..3196598 | - | 1080 | WP_042976372.1 | porin | - |
| LZ568_RS32350 (LZ568_32350) | 3197043..3197360 | + | 318 | WP_027789384.1 | non-heme iron oxygenase ferredoxin subunit | - |
| LZ568_RS32355 (LZ568_32355) | 3197364..3197675 | + | 312 | WP_027789383.1 | hypothetical protein | - |
| LZ568_RS32360 (LZ568_32360) | 3197730..3198800 | + | 1071 | WP_059697603.1 | aromatic ring-hydroxylating dioxygenase subunit alpha | - |
| LZ568_RS32365 (LZ568_32365) | 3198793..3199563 | + | 771 | WP_059697601.1 | SDR family oxidoreductase | - |
| LZ568_RS32370 (LZ568_32370) | 3199597..3200124 | + | 528 | WP_021161513.1 | cupin domain-containing protein | - |
| LZ568_RS32375 (LZ568_32375) | 3200143..3201039 | + | 897 | WP_059697599.1 | alpha/beta fold hydrolase | Toxin |
| LZ568_RS32380 (LZ568_32380) | 3201036..3201893 | + | 858 | WP_027789379.1 | IclR family transcriptional regulator | Antitoxin |
| LZ568_RS32385 (LZ568_32385) | 3201890..3202687 | + | 798 | WP_059697597.1 | SDR family oxidoreductase | - |
| LZ568_RS32390 (LZ568_32390) | 3202680..3204347 | + | 1668 | WP_059697595.1 | thiamine pyrophosphate-binding protein | - |
| LZ568_RS32395 (LZ568_32395) | 3204340..3205167 | + | 828 | WP_027789376.1 | aspartate dehydrogenase | - |
| LZ568_RS32400 (LZ568_32400) | 3205240..3206730 | + | 1491 | WP_059697594.1 | aldehyde dehydrogenase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 299 a.a. Molecular weight: 30574.83 Da Isoelectric Point: 8.3552
>T231410 WP_059697599.1 NZ_CP090609:3200143-3201039 [Burkholderia cepacia]
MSVIDKRERDRTAAFAALLGQFPEQRCAAGAAGTIGYREAGAQHAGRALPVVLLHGIGSGAASWVSQLDTLGASRRVLAW
DAPGYGVSTPVHGASPAAADYAASLNAWLEALGIERCVLVGHSLGAIVAGGLARVMPARIAGLLLVSPAGGYGSAPAETR
ESRRDARLAMLAELGPAGLAEQRSGNMLSGFANEEARAWVRWNMARIVPAGYAQATHLLANADLAADLAGFRGRTAVAVG
ANDAITPPAACKRIAAAAHVGLQVIPQAGHAGYVEAPAVYSALIDSFCRQCDQQRGLA
MSVIDKRERDRTAAFAALLGQFPEQRCAAGAAGTIGYREAGAQHAGRALPVVLLHGIGSGAASWVSQLDTLGASRRVLAW
DAPGYGVSTPVHGASPAAADYAASLNAWLEALGIERCVLVGHSLGAIVAGGLARVMPARIAGLLLVSPAGGYGSAPAETR
ESRRDARLAMLAELGPAGLAEQRSGNMLSGFANEEARAWVRWNMARIVPAGYAQATHLLANADLAADLAGFRGRTAVAVG
ANDAITPPAACKRIAAAAHVGLQVIPQAGHAGYVEAPAVYSALIDSFCRQCDQQRGLA
Download Length: 897 bp
>T231410 NZ_CP126348:1023190-1023525 [Escherichia coli]
ATGGTAAGCCGATACGTACCCGATATGGGCGATCTGATTTGGGTTGATTTTGACCCGACAAAAGGTAGCGAGCAAGCTGG
ACATCGTCCAGCTGTTGTCCTGAGTCCTTTCATGTACAACAACAAAACAGGTATGTGTCTGTGTGTTCCTTATACAACGC
AATCAAAAGGATATCCGTTCGAAGTTGTTTTATCCGGTCAGGAACGTGATGGCGTAGCGTTAGCTGATCAGGTAAAAAGT
ATCGCCTGGCGGGCAAGAGGAGCAACGAAGAAAGGAACAGTTGCCCCAGAGGAATTACAACTCATTAAAGCCAAAATTAA
CGTACTGATTGGGTAG
ATGGTAAGCCGATACGTACCCGATATGGGCGATCTGATTTGGGTTGATTTTGACCCGACAAAAGGTAGCGAGCAAGCTGG
ACATCGTCCAGCTGTTGTCCTGAGTCCTTTCATGTACAACAACAAAACAGGTATGTGTCTGTGTGTTCCTTATACAACGC
AATCAAAAGGATATCCGTTCGAAGTTGTTTTATCCGGTCAGGAACGTGATGGCGTAGCGTTAGCTGATCAGGTAAAAAGT
ATCGCCTGGCGGGCAAGAGGAGCAACGAAGAAAGGAACAGTTGCCCCAGAGGAATTACAACTCATTAAAGCCAAAATTAA
CGTACTGATTGGGTAG
Antitoxin
Download Length: 286 a.a. Molecular weight: 31511.04 Da Isoelectric Point: 6.5068
>AT231410 WP_027789379.1 NZ_CP090609:3201036-3201893 [Burkholderia cepacia]
MNEPLQRPEPENDKAEASYVVPGLERGLRILAEFSPREPVLGAPELSKRLGIPRTTVFRLLQTLESLGFLERADKDRNYK
LGIAVLRLGFEYLSSLELTDLGLPVIESLRDATGFTTHIVIRDGRDVVFVAKAQSQSPVFSSIRVNVGTRLPAHATTHGH
VLMGDLSLKELHALYPEGTLNRMTNATPETVDALYEVIREDALRGYGVSNSSFERGISVVTAPVRNETQKIVACITVTVP
RPEIDAALIADGLIDKVQRAAAELSRRLNYRSDDEHTFMKALGLR
MNEPLQRPEPENDKAEASYVVPGLERGLRILAEFSPREPVLGAPELSKRLGIPRTTVFRLLQTLESLGFLERADKDRNYK
LGIAVLRLGFEYLSSLELTDLGLPVIESLRDATGFTTHIVIRDGRDVVFVAKAQSQSPVFSSIRVNVGTRLPAHATTHGH
VLMGDLSLKELHALYPEGTLNRMTNATPETVDALYEVIREDALRGYGVSNSSFERGISVVTAPVRNETQKIVACITVTVP
RPEIDAALIADGLIDKVQRAAAELSRRLNYRSDDEHTFMKALGLR
Download Length: 858 bp
>AT231410 NZ_CP126348:1022942-1023190 [Escherichia coli]
ATGATCCACAGTAGCGTAAAGCGTTGGGGAAATTCACCGGCGGTGCGGATCCCGGCTACGTTAATGCAGGCGCTCAATCT
GAATATTGATGATGAAGTGAAGATTGACCTGGTGGATGGCAAATTAATTATTGAGCCAGTGCGTAAAGAGCCCGTATTTA
CGCTTGCTGAACTGGTCAACGACATCACGCCGGAAAACCTCCACGAGAATATCGACTGGGGAGAGCCGAAAGATAAGGAA
GTCTGGTAA
ATGATCCACAGTAGCGTAAAGCGTTGGGGAAATTCACCGGCGGTGCGGATCCCGGCTACGTTAATGCAGGCGCTCAATCT
GAATATTGATGATGAAGTGAAGATTGACCTGGTGGATGGCAAATTAATTATTGAGCCAGTGCGTAAAGAGCCCGTATTTA
CGCTTGCTGAACTGGTCAACGACATCACGCCGGAAAACCTCCACGAGAATATCGACTGGGGAGAGCCGAAAGATAAGGAA
GTCTGGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|