Detailed information of TA system TA231409

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-StbC
• Location: 3081553..3082208
• Replicon: chromosome
• Accession: NZ_CP090609
• Organism: Burkholderia cepacia strain CMCC(B)23005

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: LZ568_RS31785
• Protein ID: WP_059698675.1
• Coordinates: 3081789..3082208 (+)
• Length: 140 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: U2HMP5
• Locus tag: LZ568_RS31780
• Protein ID: WP_021158161.1
• Coordinates: 3081553..3081792 (+)
• Length: 80 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LZ568_RS31755 (LZ568_31755)	3076838..3077233	-	396	WP_027789497.1	type II toxin-antitoxin system VapC family toxin	-
LZ568_RS31760 (LZ568_31760)	3077230..3077469	-	240	WP_011659184.1	type II toxin-antitoxin system Phd/YefM family antitoxin	-
LZ568_RS31765 (LZ568_31765)	3077557..3078240	-	684	WP_059698670.1	Fe2+-dependent dioxygenase	-
LZ568_RS31770 (LZ568_31770)	3078237..3078992	-	756	WP_059698672.1	tetratricopeptide repeat protein	-
LZ568_RS31775 (LZ568_31775)	3078996..3081242	-	2247	WP_059698673.1	TonB-dependent siderophore receptor	-
LZ568_RS31780 (LZ568_31780)	3081553..3081792	+	240	WP_021158161.1	antitoxin VapB	Antitoxin
LZ568_RS31785 (LZ568_31785)	3081789..3082208	+	420	WP_059698675.1	type II toxin-antitoxin system VapC family toxin	Toxin
LZ568_RS31790 (LZ568_31790)	3082344..3083639	-	1296	WP_059698677.1	aspartate carbamoyltransferase	-
LZ568_RS31795 (LZ568_31795)	3083873..3084007	+	135	WP_021158165.1	entericidin A/B family lipoprotein	-
LZ568_RS31800 (LZ568_31800)	3084112..3084660	-	549	WP_059698680.1	hypothetical protein	-
LZ568_RS31805 (LZ568_31805)	3084845..3085798	-	954	WP_059698757.1	DMT family transporter	-
LZ568_RS31810 (LZ568_31810)	3086091..3086884	-	794	Protein_2779	AraC family transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-122)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 140 a.a.
• Molecular weight: 15193.52 Da
• Isoelectric Point: 5.7529

>T231409 WP_059698675.1 NZ_CP090609:3081789-3082208 [Burkholderia cepacia]
MILVDTNVISEPLRREPNAAVIEWLDAQNVETLFLAALSLAEIRLGVAVLPEGRRREWLHQSIEQRVLPLFRGRILPFDD
AASKAYASLRAHARAAGVAIAPSDGFIAGTAEANGLIVATRDVTPFEAMGIRVIDPWAR

Nucleotide

• Length: 420 bp

>T231409 NZ_CP126348:863938-864345 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCACTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGTATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCACCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATGGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCTGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin

Protein

• Length: 80 a.a.
• Molecular weight: 8629.79 Da
• Isoelectric Point: 5.6643

>AT231409 WP_021158161.1 NZ_CP090609:3081553-3081792 [Burkholderia cepacia]
MPVITVRNLSDEVHRALRIRAAQHGRSTEAEVRDILEQAVLPGGRLKLGTMLAAIGQEAGGFDFDAQRDKTPADPMSFE

Nucleotide

• Length: 240 bp

>AT231409 NZ_CP126348:863691-863957 [Escherichia coli]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Structures

Antitoxin

• AlphaFold DB: U2HMP5