Detailed information of TA system TA231408

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/-
• Location: 2929119..2930340
• Replicon: chromosome
• Accession: NZ_CP090609
• Organism: Burkholderia cepacia strain CMCC(B)23005

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: LZ568_RS31110
• Protein ID: WP_059698278.1
• Coordinates: 2929119..2929700 (-)
• Length: 194 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: LZ568_RS31115
• Protein ID: WP_059698276.1
• Coordinates: 2929783..2930340 (-)
• Length: 186 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LZ568_RS31095 (LZ568_31095)	2924798..2926858	-	2061	WP_059698282.1	MacB family efflux pump subunit	-
LZ568_RS31100 (LZ568_31100)	2926861..2928054	-	1194	WP_027789607.1	macrolide transporter subunit MacA	-
LZ568_RS31105 (LZ568_31105)	2928335..2929063	-	729	WP_059698280.1	class I SAM-dependent methyltransferase	-
LZ568_RS31110 (LZ568_31110)	2929119..2929700	-	582	WP_059698278.1	HD domain-containing protein	Toxin
LZ568_RS31115 (LZ568_31115)	2929783..2930340	-	558	WP_059698276.1	helix-turn-helix transcriptional regulator	Antitoxin
LZ568_RS31120 (LZ568_31120)	2930395..2931072	-	678	WP_059698274.1	hypothetical protein	-
LZ568_RS31125 (LZ568_31125)	2931432..2932835	+	1404	WP_059698272.1	hypothetical protein	-
LZ568_RS31130 (LZ568_31130)	2932932..2933510	+	579	WP_027789601.1	hypothetical protein	-
LZ568_RS31135 (LZ568_31135)	2933592..2933981	-	390	WP_059698270.1	OsmC family protein	-
LZ568_RS31140 (LZ568_31140)	2934212..2934943	+	732	WP_059698268.1	ribonuclease T2	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HD domain (16-173)

Antitoxin

• Cro/C1-type helix-turn-helix domain (12-64)

Sequences

Toxin

Protein

• Length: 194 a.a.
• Molecular weight: 21243.82 Da
• Isoelectric Point: 5.0928

>T231408 WP_059698278.1 NZ_CP090609:c2929700-2929119 [Burkholderia cepacia]
MNPDTIHARLAFLREAERLKDVLRSGHTSAGRAESTAEHSWRLCLMALVFADALPGIDTLKLLKLCVVHDLGEALHGDIP
AIEQAAHPDKSAHERDDLLTLTAPLDPARRDEIVALWDEYEAAASPEARAAKAFDKLETILQHTQGSNPPDFDYAFNLGY
GRRYTDAAPLFSAIRDIVDADTQRRIDAGGQHA

Nucleotide

• Length: 582 bp

>T231408 NZ_CP126348:c594588-594124 [Escherichia coli]
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGACGCTTTAGTTGC
CGAAGTCGAGACATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCCGCCACAAAGTTATTGGCGGTAGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGTTATCGTCTCTTCTTTCGTTATAGTGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACTCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGCAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAACCCTCACCCGAGAAACAGAAGAAACCCATTGA

Antitoxin

Protein

• Length: 186 a.a.
• Molecular weight: 20153.12 Da
• Isoelectric Point: 9.4793

>AT231408 WP_059698276.1 NZ_CP090609:c2930340-2929783 [Burkholderia cepacia]
MSASPLHAPPLGPQLKRWRALHRVKQSHAAELFGVAQSTISRWEAGLQQMSPDERATAERLLAARLDSAGDHALARLVAG
SAGRMHLVCDLTHRLLACSPARAAEFSQPLSMLLGTSLWRYATPEIVRMETALDTLGWHDRAGPPSVEFDTGANASRVVP
IRGSLCRWTRMTLSDGSAVRLVETL

Nucleotide

• Length: 558 bp

>AT231408 NZ_CP126348:c594923-594588 [Escherichia coli]
ATGCCCGCTAATGCTCGCTCTCACGCTGTACTGACCACTGAATCAAAGGTCACGATACGCGGACAAACAACTATCCCCGC
ACCAGTGCGTGAGGCCTTAAAACTGAAGCCAGGCCAGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTATTTA
TGTGCCGACTGGGAGATGAACAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATGCAGATATCCAGAACAAC
CCGCAAAAAACTCGTCCATTCAACATTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGATGATGAGAT
TGGCGACGACGAATAA