Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 1971078..1971751 Replicon chromosome
Accession NZ_CP090608
Organism Burkholderia cepacia strain CMCC(B)23005

Toxin (Protein)


Gene name vagD Uniprot ID A0A0J5X1U9
Locus tag LZ568_RS09525 Protein ID WP_027787436.1
Coordinates 1971335..1971751 (+) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID A0A4S5D574
Locus tag LZ568_RS09520 Protein ID WP_049096496.1
Coordinates 1971078..1971338 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LZ568_RS09505 (LZ568_09505) 1966633..1968885 + 2253 WP_059700202.1 TonB-dependent siderophore receptor -
LZ568_RS09510 (LZ568_09510) 1968972..1969811 + 840 WP_042975471.1 formyltransferase family protein -
LZ568_RS09515 (LZ568_09515) 1969811..1970827 + 1017 WP_059700204.1 GNAT family N-acetyltransferase -
LZ568_RS09520 (LZ568_09520) 1971078..1971338 + 261 WP_049096496.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
LZ568_RS09525 (LZ568_09525) 1971335..1971751 + 417 WP_027787436.1 PIN domain-containing protein Toxin
LZ568_RS09530 (LZ568_09530) 1971806..1972711 - 906 WP_059700206.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein -
LZ568_RS09535 (LZ568_09535) 1972680..1973753 - 1074 WP_059700375.1 type IV toxin-antitoxin system AbiEi family antitoxin -
LZ568_RS09540 (LZ568_09540) 1974096..1975259 + 1164 WP_059700208.1 M20 aminoacylase family protein -
LZ568_RS09545 (LZ568_09545) 1975413..1975952 + 540 WP_042975462.1 outer membrane protein assembly factor BamE -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-130)

Antitoxin

SpoVT-AbrB domain

(7-54)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 14536.66 Da        Isoelectric Point: 7.8895

>T231403 WP_027787436.1 NZ_CP090608:1971335-1971751 [Burkholderia cepacia]
VTTLYMLDTNICSFIMRERPPVVLSRLQSCVNAQHRIVVSAITYAEMRFGAVGRKASPKHAELVTAFVSRLDGVLSWDTA
AVDATAAIRADLAARGTPIGANDASIAGHAIAAGAVLVTNNGREFGRVAGLSLEDWAA

Download         Length: 417 bp

>T231403 NZ_CP126345:c4312703-4312530 [Escherichia coli]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTCCTGGTCGGAATAACCTGGCCAATGAGTCTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9564.84 Da        Isoelectric Point: 4.6151

>AT231403 WP_049096496.1 NZ_CP090608:1971078-1971338 [Burkholderia cepacia]
MRTVSIFKNARNQAIRIPKDMEFEGVTELEIRREGDTLMLRPVRPTWLSFASEPLADADFLAERPAVIESGRFDLSGGAA
PTESGQ

Download         Length: 261 bp

>AT231403 NZ_CP126345:c4313027-4312731 [Escherichia coli]
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCAGTGTTCTTAAGGTT
AAGATCATTGATGTATGATATGAATTTCTCTTCTATCGTGGCTGATGAATATGGGATACCACGACAATTGAATGAAAATT
CTTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTTAAATGCTTAGACTTACCGGATATT
GATTTTGACCTCAACATTATGACAGTTGATGACTATTTCCGTCAGTTTTACAAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0J5X1U9

Antitoxin

Source ID Structure
AlphaFold DB A0A4S5D574

References