Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapC-vagC/VapC-VagC
Location 162654..163291 Replicon chromosome
Accession NZ_CP090608
Organism Burkholderia cepacia strain CMCC(B)23005

Toxin (Protein)


Gene name vapC Uniprot ID A0A4R9MFH0
Locus tag LZ568_RS00730 Protein ID WP_044848378.1
Coordinates 162890..163291 (+) Length 134 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID A0A1Z3YWA1
Locus tag LZ568_RS00725 Protein ID WP_027788678.1
Coordinates 162654..162890 (+) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LZ568_RS00705 (LZ568_00705) 158632..159774 - 1143 WP_059694461.1 hypothetical protein -
LZ568_RS00710 (LZ568_00710) 159771..161474 - 1704 WP_059678233.1 thiamine pyrophosphate-binding protein -
LZ568_RS00715 (LZ568_00715) 161775..162236 + 462 WP_059694460.1 hypothetical protein -
LZ568_RS00720 (LZ568_00720) 162233..162517 + 285 WP_027788679.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family -
LZ568_RS00725 (LZ568_00725) 162654..162890 + 237 WP_027788678.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
LZ568_RS00730 (LZ568_00730) 162890..163291 + 402 WP_044848378.1 type II toxin-antitoxin system VapC family toxin Toxin
LZ568_RS00735 (LZ568_00735) 163358..164746 - 1389 WP_027788676.1 L-serine ammonia-lyase -
LZ568_RS00740 (LZ568_00740) 164777..165913 - 1137 WP_234742845.1 alginate lyase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-120)

Antitoxin

SpoVT-AbrB domain

(7-46)


Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 14987.11 Da        Isoelectric Point: 5.6518

>T231402 WP_044848378.1 NZ_CP090608:162890-163291 [Burkholderia cepacia]
MPRYMLDTNMCIYLMKNQPEQVAKRFAQCYTGDVVMSAITYAELEYGVAACANPARERRHLAALIDDIPVAPFDVAAAQA
YGPVRDATRERKRDHLDKLIAAHAVSLDVALVTNNERDFVSYPGLRLENWLND

Download         Length: 402 bp

>T231402 NZ_CP126345:c4209093-4208743 [Escherichia coli]
ATGGTAAAGAAAAGTGAATTTGAACGGGGAGACATTGTGCTGGTTGGCTTTGATCCAGCAAGCGGCCATGAACAGCAAGG
TGCTGGTCGACCTGCGCTTGTGCTCTCCGTTCAAGCCTTTAATCAACTGGGAATGACGCTGGTGGCCCCCATTACGCAGG
GCGGAAATTTTGCCCGTTATGCCGGATTTAGCGTTCCTTTACATTGCGAAGAAGGCGATGTGCACGGCGTGGTGCTGGTG
AATCAGGTGCGGATGATGGATCTACGCGCCCGGCTGGCAAAGCGTATTGGTCTGGCTGCGGATGAGGTGGTGGAAGAGGC
GTTATTACGCTTGCAGGCGGTGGTGGAATAA

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 9144.34 Da        Isoelectric Point: 5.1974

>AT231402 WP_027788678.1 NZ_CP090608:162654-162890 [Burkholderia cepacia]
MHTTKVFRNGNSQAVRIPADLAYERNDIELEIERIGDEIRIRPMRRPLTRVLEKFAKFGPDFMAEGRGDQEQADREEL

Download         Length: 237 bp

>AT231402 NZ_CP126345:c4209338-4209087 [Escherichia coli]
ATGCGTATTACCATAAAAAGATGGGGGAACAGTGCAGGTATGGTCATTCCCAATATCGTAATGAAAGAACTTAACTTACA
GCCGGGGCAGAGCGTGGAAGCGCAGGTGAGCAACAACCAACTGATTCTGACACCCATCTCCAGGCGCTACTCGCTTGATG
AACTGCTGGCACAGTGTGACATGAACGCCGCGGAACTTAGCGAGCAGGATGTCTGGGGTAAATCCACCCCTGCGGGTGAC
GAAATATGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4R9MFH0

Antitoxin

Source ID Structure
AlphaFold DB A0A1Z3YWA1

References