Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parE-vagC/RelE-VagC
Location 162233..162890 Replicon chromosome
Accession NZ_CP090608
Organism Burkholderia cepacia strain CMCC(B)23005

Toxin (Protein)


Gene name parE Uniprot ID A0A1Z3YPK5
Locus tag LZ568_RS00720 Protein ID WP_027788679.1
Coordinates 162233..162517 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID A0A1Z3YWA1
Locus tag LZ568_RS00725 Protein ID WP_027788678.1
Coordinates 162654..162890 (+) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LZ568_RS00700 (LZ568_00700) 157432..158463 + 1032 WP_059694462.1 helix-turn-helix domain-containing protein -
LZ568_RS00705 (LZ568_00705) 158632..159774 - 1143 WP_059694461.1 hypothetical protein -
LZ568_RS00710 (LZ568_00710) 159771..161474 - 1704 WP_059678233.1 thiamine pyrophosphate-binding protein -
LZ568_RS00715 (LZ568_00715) 161775..162236 + 462 WP_059694460.1 hypothetical protein -
LZ568_RS00720 (LZ568_00720) 162233..162517 + 285 WP_027788679.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
LZ568_RS00725 (LZ568_00725) 162654..162890 + 237 WP_027788678.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
LZ568_RS00730 (LZ568_00730) 162890..163291 + 402 WP_044848378.1 type II toxin-antitoxin system VapC family toxin -
LZ568_RS00735 (LZ568_00735) 163358..164746 - 1389 WP_027788676.1 L-serine ammonia-lyase -
LZ568_RS00740 (LZ568_00740) 164777..165913 - 1137 WP_234742845.1 alginate lyase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-93)

Antitoxin

SpoVT-AbrB domain

(7-46)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10794.40 Da        Isoelectric Point: 5.7133

>T231401 WP_027788679.1 NZ_CP090608:162233-162517 [Burkholderia cepacia]
MTLALHWNPKAYEDRAAIMDYIGEDDPQAAIELDELLEQRAATLPARAELYRQGRVAGTRELVVAPNYVLVYRIRPAEGI
VEILRVLHARRQWP

Download         Length: 285 bp

>T231401 NZ_CP126345:3744352-3744630 [Escherichia coli]
ATGATTCAAAGGGATATTGAATACTCGGGACAATTTTCAAAGGATGTAAAACTTGCACAAAAGCGTCATAAGGATATGAA
TAAATTGAAATATCTTATGACGCTTCTTATCAATAATGCTTTACCGCTTCCAGCTGTTTATAAAGACCACCCGCTGCAAG
GTTCATGGAAAGGTTATCGCGATGCTCATGTCGAACCGGACTGGATCCTGATTTACAAACTTACCGATAAACTTTTACGA
TTTGAGAGAACTGGAACTCACGCGGCGCTCTTTGGGTAA

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 9144.34 Da        Isoelectric Point: 5.1974

>AT231401 WP_027788678.1 NZ_CP090608:162654-162890 [Burkholderia cepacia]
MHTTKVFRNGNSQAVRIPADLAYERNDIELEIERIGDEIRIRPMRRPLTRVLEKFAKFGPDFMAEGRGDQEQADREEL

Download         Length: 237 bp

>AT231401 NZ_CP126345:3744089-3744349 [Escherichia coli]
ATGGCTGCTAACGCATTTGTTCGCGCCCGAATCGATGAAGATCTGAAGAATCAGGCGGCGGACGTACTGGCCGGGATGGG
GCTGACCATCTCTGACCTGGTTCGCATAACCCTCACAAAGGTCGCGCGTGAAAAGGCATTGCCGTTTGATTTACGCGAGC
CTAATCAATTAACCATTCAATCAATCAAAAACAGCGAAGCTGGCGTTGATGTTCATAAGGCCAAAGATGCCGATGATTTA
TTTGATAAATTAGGAATTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1Z3YPK5

Antitoxin

Source ID Structure
AlphaFold DB A0A1Z3YWA1

References