Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/-
Location 3790252..3790905 Replicon chromosome
Accession NZ_CP090607
Organism Acinetobacter baumannii strain MRSN 58

Toxin (Protein)


Gene name cptA Uniprot ID B0V6V2
Locus tag LQQ45_RS19000 Protein ID WP_000931890.1
Coordinates 3790252..3790641 (-) Length 130 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID V5V966
Locus tag LQQ45_RS19005 Protein ID WP_001288210.1
Coordinates 3790648..3790905 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQQ45_RS18985 (LQQ45_18985) 3785370..3787565 - 2196 WP_001158905.1 TRAP transporter large permease subunit -
LQQ45_RS18990 (LQQ45_18990) 3787753..3788319 - 567 WP_000651536.1 rhombosortase -
LQQ45_RS18995 (LQQ45_18995) 3788397..3789482 - 1086 WP_000049106.1 hypothetical protein -
LQQ45_RS19000 (LQQ45_19000) 3790252..3790641 - 390 WP_000931890.1 membrane protein Toxin
LQQ45_RS19005 (LQQ45_19005) 3790648..3790905 - 258 WP_001288210.1 succinate dehydrogenase assembly factor 2 Antitoxin
LQQ45_RS19010 (LQQ45_19010) 3791093..3792265 + 1173 WP_001190546.1 acyl-CoA dehydrogenase family protein -
LQQ45_RS19015 (LQQ45_19015) 3792315..3793805 - 1491 WP_000415133.1 NAD(P)/FAD-dependent oxidoreductase -
LQQ45_RS19020 (LQQ45_19020) 3793986..3794363 - 378 WP_001216380.1 50S ribosomal protein L17 -
LQQ45_RS19025 (LQQ45_19025) 3794382..3795389 - 1008 WP_000198631.1 DNA-directed RNA polymerase subunit alpha -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Flavinator of succinate dehydrogenase

(10-82)


Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 15649.98 Da        Isoelectric Point: 10.4623

>T231400 WP_000931890.1 NZ_CP090607:c3790641-3790252 [Acinetobacter baumannii]
MLNHLNFKLKYSRFSIIFQFFIGLSLAILFYQLMPLLWWLVVISLLFISFIFFLKRPQLAKIAYLDKKLWSLAYHSQNTI
SRVKILKIIDYQIFIVIYFEGHKTLTSIIWFDQMSLAEWKKLKTLEKLY

Download         Length: 390 bp

>T231400 NZ_CP126345:3539303-3539845 [Escherichia coli]
ATGGTCGACAAGCATGAAGAGATTACTCTGCCCATAGTCCTCTCCTGTAATTATCAGTCTGATATTACTTATCCTGGGCA
AAAACAGTTTGATTGCGGTAACCCTGTTATCGATAAATTTGTACGCGCATCGCTAAAGAAAAGTGTGCGTAATAGCGACT
GTGCGGCTAAAGCACTTATTGACAGACAAAGTGGTGAACTGATCGGCATCTGTACTTTTACGGCATATTCGCTGGAAAAA
CAACGCGTTTCTGGCGTCCTTCAGGGTTCACAACCTTCAGAAATTGGTGTTGTCAGATTAGTCATGTTGGGGGTAGCACG
GAAGTATCAAAAGCGGGGCTTTGGTCAGGACCTACTATGTGATTTTTTTGAACATGTAAAAATAATTCACCAGGCATTAC
CAATTAAAGGGGTTTATCTTGATGCTGACCCTGCCGCCATTAATTTTTATGCTCGTCTCGGCTTTGTTCAGCTTTCAGCG
ACACCAAATGCTTTTGGTGCTGTACCTATGTTTTTGGCGATTCAGCATATTCTCGCGGCTTAG

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 10318.77 Da        Isoelectric Point: 4.6150

>AT231400 WP_001288210.1 NZ_CP090607:c3790905-3790648 [Acinetobacter baumannii]
MSEEMTLEERKVIYRARRGLKEIDVYFDPYVKNYYLKADPAEKALFAELVEQEDPDLLDWFMEVSEPPRTELRDFIYKLK
HYVHG

Download         Length: 258 bp

>AT231400 NZ_CP126345:3539008-3539319 [Escherichia coli]
ATGCCTGGAAAAACAGCCACTCTACCCGATGTCGATAAAACGCTGAAAAATGCGCGGGTCGAACTCAAAACCAGTCCCGA
CGCCAAAAACAAACTTCGTGAAGCTGCGCAAGCCGTTGGGGTAGATTTAAGCGCTTTTATTTTGAGCGCTGCTATGGAAC
GCGCCGAAAGTGTGCTTGATAACCAACGTCGCCGTGAGCTTTCGAATCAAAGCTGGGAACTGATGAACCAACTCATCGCT
GAACCTGCTCAACCGACGCTCGCCCTCAAGGCGTTAATGAAAAGGAAAAACAGCGATGGTCGACAAGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0J1A4U0

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BQM7

References