Detailed information of TA system TA231399

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): pmenTA/darT(toxin)
• Location: 1473596..1475337
• Replicon: chromosome
• Accession: NZ_CP090607
• Organism: Acinetobacter baumannii strain MRSN 58

Toxin (Protein)

• Gene name: pmenT
• Uniprot ID: N9S537
• Locus tag: LQQ45_RS07895
• Protein ID: WP_000233088.1
• Coordinates: 1473596..1474252 (+)
• Length: 219 a.a.

Antitoxin (Protein)

• Gene name: pmenA
• Uniprot ID: -
• Locus tag: LQQ45_RS07900
• Protein ID: WP_003112112.1
• Coordinates: 1474252..1475337 (+)
• Length: 362 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LQQ45_RS07885 (LQQ45_07885)	1468751..1470121	+	1371	WP_003114524.1	EH signature domain-containing protein	-
LQQ45_RS07890 (LQQ45_07890)	1470154..1473357	+	3204	WP_003129329.1	DEAD/DEAH box helicase	-
LQQ45_RS07895 (LQQ45_07895)	1473596..1474252	+	657	WP_000233088.1	DUF4433 domain-containing protein	Toxin
LQQ45_RS07900 (LQQ45_07900)	1474252..1475337	+	1086	WP_003112112.1	macro domain-containing protein	Antitoxin
LQQ45_RS07905 (LQQ45_07905)	1476125..1477006	+	882	WP_000732866.1	MetQ/NlpA family ABC transporter substrate-binding protein	-
LQQ45_RS07910 (LQQ45_07910)	1477131..1477397	-	267	WP_000703423.1	hypothetical protein	-
LQQ45_RS07915 (LQQ45_07915)	1478061..1478615	+	555	WP_002024621.1	TetR/AcrR family transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• ssDNA thymidine ADP-ribosyltransferase, DarT (18-218)

Antitoxin

• Macro domain (18-129)

Sequences

Toxin

Protein

• Length: 219 a.a.
• Molecular weight: 25316.92 Da
• Isoelectric Point: 7.1033

>T231399 WP_000233088.1 NZ_CP090607:1473596-1474252 [Acinetobacter baumannii]
MVGRNYSDVLNPQKALIWRIVHRDNIPWILENGLHSSNSPTQCVNWVQIGSPELIEKRQLHPVPVGKKGVLSDYIPFYFT
PFSPMLLNIKSGRGGVRQRTNDEIVILVSSLYQLQQQQIPFVFTNSHAYYQWAEFYTDLSSLNEIDWSILQARDFKRDMD
DPAKFERYQAEALVHQHCPTKVLIGVICYTETVKAQIEQWLQQADVNIPVHVRQGVYF

Nucleotide

• Length: 657 bp

>T231399 NZ_CP126345:3503983-3504201 [Escherichia coli]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin

Protein

• Length: 362 a.a.
• Molecular weight: 41063.20 Da
• Isoelectric Point: 6.0689

>AT231399 WP_003112112.1 NZ_CP090607:1474252-1475337 [Acinetobacter baumannii]
MIRYTTGNLLDAPVEALVNTVNTVGVMGKGIALMFKERFPKNMAAYSQACKAGQVTTGKMFVTETNELMGARWIINFPTK
QHWRDKSKLQWIEDGLQDLKKFIIDHQVKSIAIPPLGAGNGGLEWSRVKSKIETELSDLEYVDILIFEPTTQYQNVAKKI
GVSQLTPARAMIAELVRRYWVLGIECSLLEIQKLAWFLQRVIEQKQLPNELKLNFQANYYGPYASNLDHLLNAMDGSYLK
SDKRIPDCDPLDVIWFNDQQKSKVQGYLISEAKEYMAAVEGAATLIEGFESPFGMELLATVDWLIYKEGYQPNVESIQEG
LANWSAGERWARRKSDLFKAEHIQFALQKLDGFAYFHTDVT

Nucleotide

• Length: 1086 bp

>AT231399 NZ_CP126345:3503583-3503957 [Escherichia coli]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGCCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTTAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG

Structures

Toxin

• AlphaFold DB: N9S537