Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 4916470..4917005 Replicon chromosome
Accession NZ_CP090596
Organism Pectobacterium aroidearum strain QJ003

Toxin (Protein)


Gene name relE Uniprot ID C6DJA0
Locus tag L0Y20_RS22210 Protein ID WP_015842269.1
Coordinates 4916718..4917005 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q6DB37
Locus tag L0Y20_RS22205 Protein ID WP_010281712.1
Coordinates 4916470..4916721 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L0Y20_RS22180 (L0Y20_22155) 4911765..4912898 + 1134 WP_256599162.1 alkylhydroperoxidase domain protein -
L0Y20_RS22185 (L0Y20_22160) 4912941..4913564 - 624 WP_256599163.1 LysE family translocator -
L0Y20_RS22190 (L0Y20_22165) 4913746..4914450 + 705 WP_256599164.1 SMI1/KNR4 family protein -
L0Y20_RS22195 (L0Y20_22170) 4914520..4915275 + 756 WP_181845543.1 thiol:disulfide interchange protein DsbG -
L0Y20_RS22200 (L0Y20_22175) 4915310..4916215 - 906 WP_256599165.1 siderophore-interacting protein -
L0Y20_RS22205 (L0Y20_22180) 4916470..4916721 + 252 WP_010281712.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
L0Y20_RS22210 (L0Y20_22185) 4916718..4917005 + 288 WP_015842269.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
L0Y20_RS22215 (L0Y20_22190) 4917114..4918466 - 1353 WP_039474428.1 glutathione-disulfide reductase -
L0Y20_RS22220 (L0Y20_22195) 4918594..4919436 - 843 WP_015842271.1 23S rRNA (adenine(2030)-N(6))-methyltransferase RlmJ -
L0Y20_RS22225 (L0Y20_22200) 4919655..4920383 + 729 WP_043881851.1 DUF1266 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-84)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11074.15 Da        Isoelectric Point: 10.3527

>T231386 WP_015842269.1 NZ_CP090596:4916718-4917005 [Pectobacterium aroidearum]
MSYSVKFREDALKEWLKLDKTIQQQFAKKLKKCCENPHIPSAKLRGMKDCYKIKLRASGFRLVYEVIDDVLIIAVVAVGK
RERSGVYHLASERMR

Download         Length: 288 bp

>T231386 NZ_CP126345:702131-702508 [Escherichia coli]
ATGAAAACATTACCTGTATTACCCGGGCAGGCGGCCGGTTCACGCCCGTCTCCGGTTGAAATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCATTACGGCCTCACGCTGAATGACACACCGTTCGCCGATGAACGTGTGATTGAGCAGCATATTG
AAGCTGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTTGAAAAATACGCGCTGGTACGTACCGACCAGCCGGGATTC
AGCACCTGTACCCACTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCCCGCCGGGCGACAGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATGGCATTACCCAGGGGAAGCATCCGGAGGCGAAACAATGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9117.47 Da        Isoelectric Point: 4.0637

>AT231386 WP_010281712.1 NZ_CP090596:4916470-4916721 [Pectobacterium aroidearum]
MPNIILSDTSASVSELKKNPMATVNAGDGLPVAILNRNQPAFYCIPADLYEKMLDALDDQELVKLIGERKNQPLVDVDLD
SFL

Download         Length: 252 bp

>AT231386 NZ_CP126345:701673-702041 [Escherichia coli]
GTGTCAGACACGCTCCATGAAACAAATTATCCCGACGACAACAACGACCGCCCCTGGTGGGGGCTACCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAAGACAACCAGTTGCATTACCTTGCCGACCGTGCCGGTATCAGAGGCCGGT
TCAGCGACGCGGATGCGTACCACCTGGACCAAGCCCTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCGAAGCCGACACCCTCGGCTCCTG
TGGCTACGTTTATATGGCTGTTTATCCGACGCCCGAAACGAAAAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3S0XQ75

Antitoxin

Source ID Structure
AlphaFold DB A0A0M2EZP0

References