Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1239889..1240514 Replicon chromosome
Accession NZ_CP090596
Organism Pectobacterium aroidearum strain QJ003

Toxin (Protein)


Gene name Hha Uniprot ID C6DB72
Locus tag L0Y20_RS05535 Protein ID WP_005976087.1
Coordinates 1239889..1240092 (-) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID C6DB73
Locus tag L0Y20_RS05540 Protein ID WP_005976089.1
Coordinates 1240146..1240514 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L0Y20_RS05505 (L0Y20_05485) 1235330..1235668 + 339 WP_002208627.1 P-II family nitrogen regulator -
L0Y20_RS05510 (L0Y20_05490) 1235706..1236992 + 1287 WP_015839357.1 ammonium transporter AmtB -
L0Y20_RS05515 (L0Y20_05495) 1237146..1238009 - 864 WP_015839358.1 acyl-CoA thioesterase II -
L0Y20_RS05520 (L0Y20_05500) 1238222..1238803 + 582 WP_181830022.1 YbaY family lipoprotein -
L0Y20_RS05525 (L0Y20_05505) 1238823..1239143 - 321 WP_015839360.1 MGMT family protein -
L0Y20_RS05535 (L0Y20_05515) 1239889..1240092 - 204 WP_005976087.1 HHA domain-containing protein Toxin
L0Y20_RS05540 (L0Y20_05520) 1240146..1240514 - 369 WP_005976089.1 Hha toxicity modulator TomB Antitoxin
L0Y20_RS05545 (L0Y20_05525) 1241111..1241254 - 144 WP_005976091.1 type B 50S ribosomal protein L36 -
L0Y20_RS05550 (L0Y20_05530) 1241272..1241520 - 249 WP_181830023.1 type B 50S ribosomal protein L31 -
L0Y20_RS05555 (L0Y20_05535) 1241755..1244883 - 3129 WP_256599595.1 efflux RND transporter permease subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-118)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8145.52 Da        Isoelectric Point: 8.9008

>T231383 WP_005976087.1 NZ_CP090596:c1240092-1239889 [Pectobacterium aroidearum]
MKKIDYLMRLRKCTTIDTLERVIEKNKYELSNDELEMFFSAADHRLAELTMNKLYDKVPTAVWRYVR

Download         Length: 204 bp

>T231383 NZ_CP126345:267844-268074 [Escherichia coli]
CTGGATCAGCTATTTAAATCACCTTTACCTCAAGGAATCAAATGGACTGATATAGAATCTCTGGTTAAAGCGTTAGGCGG
AGAAATTAAGGAAGGTAGGGGGTCGCGCTGTAAGTTCATACTAAATATGAGCGTTGCGTGTTTCCATCGGCCTCATCCGT
CGCCAGATACCGATAAAGGCGCTGTAGAAAGCGTGCGTGACTGGTTACTAAGTATAGGGGTAAAACCATGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14032.77 Da        Isoelectric Point: 4.4787

>AT231383 WP_005976089.1 NZ_CP090596:c1240514-1240146 [Pectobacterium aroidearum]
MDEYTPKHYDIAQLRFLCENLCDESIATLGDSSHGWVNDPTSAINLQLNELIEHIATFILTFKIKYPNESELSEQVEKYL
DDTYVLFSNYGINDAELRRWQKSKAKLFGMFSGENVCTPAKT

Download         Length: 369 bp

>AT231383 NZ_CP126345:268071-268430 [Escherichia coli]
ATGATCAAACTGAAGACGCCAAACTCTATGGAGATTGCCGGGCAACCTGCTGTTATCACTTACGTGCCAGAACTGAATGC
ATTTCGTGGCAAATTCCTGGGCTTGTCAGGTTATTGTGATTTTGTCTCTGACAGCATTCAGGGGCTGCAAAAAGAAGGGG
AACTTTCCCTGCGAGAGTATCTTGAGGATTGTAAAGCTGCGGGTATTGAGCCGTATGCGCGTACAGAAAAGATTAAGACC
TTTACGTTACGCTATCCAGAATCGCTGAGTGAACGCCTTAATAATGCGGCTGCGCAGCAACAAGTCTCTGTTAATACCTA
TATTATTGAAACACTGAATGAGCGTTTGAATCATTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1D7Z3F0

Antitoxin

Source ID Structure
AlphaFold DB A0A1D7Z3G5

References