Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 759926..760586 Replicon chromosome
Accession NZ_CP090596
Organism Pectobacterium aroidearum strain QJ003

Toxin (Protein)


Gene name cptA Uniprot ID A0A7W2E4X8
Locus tag L0Y20_RS03310 Protein ID WP_012773341.1
Coordinates 760173..760586 (+) Length 138 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID C6D8Y5
Locus tag L0Y20_RS03305 Protein ID WP_012773340.1
Coordinates 759926..760192 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L0Y20_RS03285 (L0Y20_03285) 755918..756922 - 1005 WP_181845151.1 LacI family DNA-binding transcriptional regulator -
L0Y20_RS03290 (L0Y20_03290) 756966..757574 - 609 WP_181829659.1 HD domain-containing protein -
L0Y20_RS03295 (L0Y20_03295) 757987..758634 + 648 WP_181829658.1 hemolysin III family protein -
L0Y20_RS03300 (L0Y20_03300) 758689..759690 - 1002 WP_194431591.1 tRNA-modifying protein YgfZ -
L0Y20_RS03305 (L0Y20_03305) 759926..760192 + 267 WP_012773340.1 FAD assembly factor SdhE Antitoxin
L0Y20_RS03310 (L0Y20_03310) 760173..760586 + 414 WP_012773341.1 protein YgfX Toxin
L0Y20_RS03315 (L0Y20_03315) 760656..761591 + 936 WP_225181483.1 23S rRNA (adenine(1618)-N(6))-methyltransferase RlmF -
L0Y20_RS03320 (L0Y20_03320) 761637..761960 - 324 WP_180777498.1 hypothetical protein -
L0Y20_RS03325 (L0Y20_03325) 761989..762507 - 519 WP_012773344.1 flavodoxin FldB -
L0Y20_RS03330 (L0Y20_03330) 762670..763998 - 1329 WP_181845156.1 MFS transporter -
L0Y20_RS03335 (L0Y20_03335) 764310..765209 + 900 WP_256599406.1 site-specific tyrosine recombinase XerD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(2-132)

Antitoxin

Flavinator of succinate dehydrogenase

(8-79)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 16302.21 Da        Isoelectric Point: 10.6525

>T231381 WP_012773341.1 NZ_CP090596:760173-760586 [Pectobacterium aroidearum]
VAQWQCDLRVSWRMQLLSLIVHGLLVLLILLAPWPDGYAWLWLCLVTMVMFGFIRSQRNIKSRQGEIVLLSETTLNWRQQ
EWQIVKRPWLLKNGVLLSLQAVNGKDRQQLWLASDSMGDDEWRHLRQLLLQQKNWAR

Download         Length: 414 bp

>T231381 NZ_CP126343:c4249569-4249396 [Escherichia coli]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTCCTGGTCGGAATAACCTGGCCAATGAGTCTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10465.94 Da        Isoelectric Point: 6.2223

>AT231381 WP_012773340.1 NZ_CP090596:759926-760192 [Pectobacterium aroidearum]
MEIDNKSRIHWACRRGMRELDIAIMPFFEHDYDTLSDSDKRTFVRLLQSDDPDLFNWLMNHGEPKDGELKRMISLIQTRN
KDRGPVAM

Download         Length: 267 bp

>AT231381 NZ_CP126343:c4249893-4249597 [Escherichia coli]
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCAGTGTTCTTAAGATT
AAGATCATTGATGTATGATATGAATTTCTCTTCTATCGTGGCTGATGAATATGGGATACCACGACAATTGAATGAAAATT
CCTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTTAAATGCTTAGACTTACCGGATATT
GATTTTGACCTCAACATTATGACAGTTGATGACTATTTCCGTCAGTTTTACAAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7W2E4X8

Antitoxin

Source ID Structure
AlphaFold DB A0A7W2E501

References