Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 4903572..4904107 Replicon chromosome
Accession NZ_CP090595
Organism Pectobacterium aroidearum strain QJ011

Toxin (Protein)


Gene name relE Uniprot ID C6DJA0
Locus tag L0Y21_RS22110 Protein ID WP_015842269.1
Coordinates 4903820..4904107 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q6DB37
Locus tag L0Y21_RS22105 Protein ID WP_010281712.1
Coordinates 4903572..4903823 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L0Y21_RS22080 (L0Y21_22055) 4898867..4900000 + 1134 WP_256599162.1 alkylhydroperoxidase domain protein -
L0Y21_RS22085 (L0Y21_22060) 4900043..4900666 - 624 WP_256599163.1 LysE family translocator -
L0Y21_RS22090 (L0Y21_22065) 4900848..4901552 + 705 WP_256599164.1 SMI1/KNR4 family protein -
L0Y21_RS22095 (L0Y21_22070) 4901622..4902377 + 756 WP_181845543.1 thiol:disulfide interchange protein DsbG -
L0Y21_RS22100 (L0Y21_22075) 4902412..4903317 - 906 WP_256599165.1 siderophore-interacting protein -
L0Y21_RS22105 (L0Y21_22080) 4903572..4903823 + 252 WP_010281712.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
L0Y21_RS22110 (L0Y21_22085) 4903820..4904107 + 288 WP_015842269.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
L0Y21_RS22115 (L0Y21_22090) 4904216..4905568 - 1353 WP_039474428.1 glutathione-disulfide reductase -
L0Y21_RS22120 (L0Y21_22095) 4905696..4906538 - 843 WP_015842271.1 23S rRNA (adenine(2030)-N(6))-methyltransferase RlmJ -
L0Y21_RS22125 (L0Y21_22100) 4906757..4907485 + 729 WP_043881851.1 DUF1266 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-84)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11074.15 Da        Isoelectric Point: 10.3527

>T231375 WP_015842269.1 NZ_CP090595:4903820-4904107 [Pectobacterium aroidearum]
MSYSVKFREDALKEWLKLDKTIQQQFAKKLKKCCENPHIPSAKLRGMKDCYKIKLRASGFRLVYEVIDDVLIIAVVAVGK
RERSGVYHLASERMR

Download         Length: 288 bp

>T231375 NZ_CP126343:2654052-2654159 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCGGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9117.47 Da        Isoelectric Point: 4.0637

>AT231375 WP_010281712.1 NZ_CP090595:4903572-4903823 [Pectobacterium aroidearum]
MPNIILSDTSASVSELKKNPMATVNAGDGLPVAILNRNQPAFYCIPADLYEKMLDALDDQELVKLIGERKNQPLVDVDLD
SFL

Download         Length: 252 bp

>AT231375 NZ_CP126343:c2654005-2653940 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3S0XQ75

Antitoxin

Source ID Structure
AlphaFold DB A0A0M2EZP0

References