Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 759929..760589 Replicon chromosome
Accession NZ_CP090595
Organism Pectobacterium aroidearum strain QJ011

Toxin (Protein)


Gene name cptA Uniprot ID A0A7W2E4X8
Locus tag L0Y21_RS03310 Protein ID WP_012773341.1
Coordinates 760176..760589 (+) Length 138 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID C6D8Y5
Locus tag L0Y21_RS03305 Protein ID WP_012773340.1
Coordinates 759929..760195 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L0Y21_RS03285 (L0Y21_03285) 755921..756925 - 1005 WP_181845151.1 LacI family DNA-binding transcriptional regulator -
L0Y21_RS03290 (L0Y21_03290) 756969..757577 - 609 WP_181829659.1 HD domain-containing protein -
L0Y21_RS03295 (L0Y21_03295) 757990..758637 + 648 WP_181829658.1 hemolysin III family protein -
L0Y21_RS03300 (L0Y21_03300) 758692..759693 - 1002 WP_194431591.1 tRNA-modifying protein YgfZ -
L0Y21_RS03305 (L0Y21_03305) 759929..760195 + 267 WP_012773340.1 FAD assembly factor SdhE Antitoxin
L0Y21_RS03310 (L0Y21_03310) 760176..760589 + 414 WP_012773341.1 protein YgfX Toxin
L0Y21_RS03315 (L0Y21_03315) 760659..761594 + 936 WP_225181483.1 23S rRNA (adenine(1618)-N(6))-methyltransferase RlmF -
L0Y21_RS03320 (L0Y21_03320) 761640..761963 - 324 WP_180777498.1 hypothetical protein -
L0Y21_RS03325 (L0Y21_03325) 761992..762510 - 519 WP_012773344.1 flavodoxin FldB -
L0Y21_RS03330 (L0Y21_03330) 762673..764001 - 1329 WP_181845156.1 MFS transporter -
L0Y21_RS03335 (L0Y21_03335) 764313..765212 + 900 WP_256599406.1 site-specific tyrosine recombinase XerD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(2-132)

Antitoxin

Flavinator of succinate dehydrogenase

(8-79)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 16302.21 Da        Isoelectric Point: 10.6525

>T231371 WP_012773341.1 NZ_CP090595:760176-760589 [Pectobacterium aroidearum]
VAQWQCDLRVSWRMQLLSLIVHGLLVLLILLAPWPDGYAWLWLCLVTMVMFGFIRSQRNIKSRQGEIVLLSETTLNWRQQ
EWQIVKRPWLLKNGVLLSLQAVNGKDRQQLWLASDSMGDDEWRHLRQLLLQQKNWAR

Download         Length: 414 bp

>T231371 NZ_CP126343:1998373-1998476 [Escherichia coli]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10465.94 Da        Isoelectric Point: 6.2223

>AT231371 WP_012773340.1 NZ_CP090595:759929-760195 [Pectobacterium aroidearum]
MEIDNKSRIHWACRRGMRELDIAIMPFFEHDYDTLSDSDKRTFVRLLQSDDPDLFNWLMNHGEPKDGELKRMISLIQTRN
KDRGPVAM

Download         Length: 267 bp

>AT231371 NZ_CP126343:c1998514-1998243 [Escherichia coli]
AAAGTCAGCGAAGGAAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCCCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGTGGTGGTCATCAGCTGAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTTTAT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7W2E4X8

Antitoxin

Source ID Structure
AlphaFold DB A0A7W2E501

References