Detailed information of TA system TA231368

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 205887..206504
• Replicon: chromosome
• Accession: NZ_CP090595
• Organism: Pectobacterium aroidearum strain QJ011

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: C6DHN3
• Locus tag: L0Y21_RS00880
• Protein ID: WP_010281507.1
• Coordinates: 206325..206504 (-)
• Length: 60 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: L0Y21_RS00875
• Protein ID: WP_180779155.1
• Coordinates: 205887..206297 (-)
• Length: 137 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L0Y21_RS00860 (L0Y21_00860)	201732..202775	-	1044	WP_256599251.1	DNA-binding transcriptional regulator CytR	-
L0Y21_RS00865 (L0Y21_00865)	203052..205250	-	2199	WP_256599252.1	primosomal protein N'	-
L0Y21_RS00870 (L0Y21_00870)	205545..205760	+	216	WP_012772907.1	50S ribosomal protein L31	-
L0Y21_RS00875 (L0Y21_00875)	205887..206297	-	411	WP_180779155.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
L0Y21_RS00880 (L0Y21_00880)	206325..206504	-	180	WP_010281507.1	type II toxin-antitoxin system HicA family toxin	Toxin
L0Y21_RS00885 (L0Y21_00885)	206602..207612	-	1011	WP_256599253.1	iron ABC transporter permease	-
L0Y21_RS00890 (L0Y21_00890)	207609..208571	-	963	WP_256599254.1	ABC transporter substrate-binding protein	-
L0Y21_RS00895 (L0Y21_00895)	208581..209378	-	798	WP_181847425.1	ABC transporter ATP-binding protein	-
L0Y21_RS00900 (L0Y21_00900)	209594..209911	-	318	WP_005973355.1	met regulon transcriptional regulator MetJ	-
L0Y21_RS00905 (L0Y21_00905)	210099..211259	+	1161	WP_012772912.1	cystathionine gamma-synthase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (4-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-128)

Sequences

Toxin

Protein

• Length: 60 a.a.
• Molecular weight: 6560.69 Da
• Isoelectric Point: 10.7838

>T231368 WP_010281507.1 NZ_CP090595:c206504-206325 [Pectobacterium aroidearum]
MDSRTLIAEIKADGWELIRVNGSHHHFMHPSKPGLVTIPHPKKDLPIGTVKSIRKQAGI

Nucleotide

• Length: 180 bp

>T231368 NZ_CP126343:c1115457-1115074 [Escherichia coli]
ATGAAAACATTACCTGTATTACCCGGGCAGGCGGCCAGTTCACGCCCGTCTCCGGTTGAAATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTACGGCCTTACGCTGAATGACACACCGTTCGCCGATGAACGTGTGATTGAGCAGCATATTG
AAGCTGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTTGAAAAATACGCACTGGTACGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGTATTGATATTCTCCGGGCTCGCCGGGCAACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGCATCAGGAGTCGAAACGATGCAACTGA

Antitoxin

Protein

• Length: 137 a.a.
• Molecular weight: 14492.36 Da
• Isoelectric Point: 4.3391

>AT231368 WP_180779155.1 NZ_CP090595:c206297-205887 [Pectobacterium aroidearum]
MFYPIAIEAGDDTHAYGVTVPDLPGCFSAGDTLDDAIANAKEAITGHIELLVEMGQDIPTVSTVGQLAKGSEYAGYTWAV
VDIDVTRLMGGSEKINVTLPKSLIDRIDRCVASNPEFKSRSGFLAQAALERISSSR

Nucleotide

• Length: 411 bp

>AT231368 NZ_CP126343:c1115915-1115547 [Escherichia coli]
GTGTCAGACACATTCTCCGGGACAACGCATCCCGATGACAATCACGACCGCCCCTGGTGGGGGCTGCCCTGTACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTACAGACCGCGCCGGTATCAGAGGCCGGT
TCAGCGATGCGGATGCGAACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCAGT
GAACTGAATCCCCACCGTCAGAATACCGTCACGCTGTATGTTAAAGGGCTGACCTGCCATGCGGACACCCTCGGCAGCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAATGAAAAATTAA

Structures

Toxin

• AlphaFold DB: A0A7W2I1S0