Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 168691..169325 Replicon chromosome
Accession NZ_CP090595
Organism Pectobacterium aroidearum strain QJ011

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag L0Y21_RS00710 Protein ID WP_181845733.1
Coordinates 168691..168966 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag L0Y21_RS00715 Protein ID WP_181830203.1
Coordinates 168963..169325 (+) Length 121 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L0Y21_RS00695 (L0Y21_00695) 165712..167082 - 1371 WP_010281575.1 envelope stress sensor histidine kinase CpxA -
L0Y21_RS00700 (L0Y21_00700) 167079..167777 - 699 WP_012772878.1 envelope stress response regulator transcription factor CpxR -
L0Y21_RS00705 (L0Y21_00705) 167931..168455 + 525 WP_225181785.1 cell-envelope stress modulator CpxP -
L0Y21_RS00710 (L0Y21_00710) 168691..168966 + 276 WP_181845733.1 type II toxin-antitoxin system HicA family toxin Toxin
L0Y21_RS00715 (L0Y21_00715) 168963..169325 + 363 WP_181830203.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
L0Y21_RS00720 (L0Y21_00720) 169700..170887 + 1188 WP_180779137.1 sugar transporter -
L0Y21_RS00725 (L0Y21_00725) 170931..171833 + 903 WP_181845732.1 CDF family cation-efflux transporter FieF -
L0Y21_RS00730 (L0Y21_00730) 172041..173003 + 963 WP_012772882.1 6-phosphofructokinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(30-80)

Antitoxin

Uncharacterised protein family HicB

(61-113)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10051.64 Da        Isoelectric Point: 11.1875

>T231367 WP_181845733.1 NZ_CP090595:168691-168966 [Pectobacterium aroidearum]
MQGKIASLRKKQRETLSQIFKTPVLSGVKWSNVESLITALGGEIKEGSGSRVRFLLNGSIARFHRPHPSPDTDKGALVNL
REWLESIGVKP

Download         Length: 276 bp

>T231367 NZ_CP126343:996149-996484 [Escherichia coli]
ATGGTAAGCCGATACGTACCCGATATGGGCGATCTGATTTGGGTTGATTTTGACCCGACAAAAGGTAGCGAGCAAGCTGG
ACATCGTCCAGCTGTTGTCCTGAGTCCTTTCATGTACAACAACAAAACAGGTATGTGTCTGTGTGTTCCTTGTACAACGC
AATCAAAAGGATATCCGTTCGAAGTTGTTTTATCCGGTCAGGAACGTGATGGCGTAGCGTTAGCTGATCAGGTAAAAAGT
ATCGCCTGGCGGGCAAGAGGAGCAACGAAGAAAGGAACAGTTGCCCCAGAGGAATTACAACTCATTAAAGCCAAAATTAA
CGTACTGATTGGGTAG

Antitoxin


Download         Length: 121 a.a.        Molecular weight: 13577.41 Da        Isoelectric Point: 4.4981

>AT231367 WP_181830203.1 NZ_CP090595:168963-169325 [Pectobacterium aroidearum]
MTKALNTPNTMVVSGQPAIISYVPEIGMFRGKFIGLSGYCDFVADSINGLRNEGEISLREYLEDCQENGIEPYEREEKVK
TFTLRYPESFGERLTIAAAERQISVNTFIVETLNERMKQA

Download         Length: 363 bp

>AT231367 NZ_CP126343:995901-996149 [Escherichia coli]
ATGATCCACAGTAGCGTAAAGCGTTGGGGAAATTCACCGGCGGTGCGGATCCCGGCTACGTTAATGCAGGCGCTCAATCT
GAATATTGATGATGAAGTGAAGATTGACCTGGTGGATGGCAAATTAATTATTGAGCCAGTGCGTAAAGAGCCCGTATTTA
CGCTTGCTGAACTGGTCAACGACATCACGCCGGAAAACCTCCACGAGAATATCGACTGGGGAGAGCCGAAAGATAAGGAA
GTCTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References