Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 4748833..4749368 Replicon chromosome
Accession NZ_CP090594
Organism Pectobacterium aroidearum strain QJ034

Toxin (Protein)


Gene name relE Uniprot ID C6DJA0
Locus tag L0Y22_RS21360 Protein ID WP_015842269.1
Coordinates 4749081..4749368 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q6DB37
Locus tag L0Y22_RS21355 Protein ID WP_010281712.1
Coordinates 4748833..4749084 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L0Y22_RS21325 (L0Y22_21300) 4744226..4744663 + 438 WP_256542605.1 RICIN domain-containing protein -
L0Y22_RS21330 (L0Y22_21305) 4744951..4745262 + 312 WP_256542606.1 LysR substrate-binding domain-containing protein -
L0Y22_RS21335 (L0Y22_21310) 4745304..4745927 - 624 WP_256542607.1 LysE family translocator -
L0Y22_RS21340 (L0Y22_21315) 4746109..4746813 + 705 WP_256542608.1 SMI1/KNR4 family protein -
L0Y22_RS21345 (L0Y22_21320) 4746883..4747638 + 756 WP_181845543.1 thiol:disulfide interchange protein DsbG -
L0Y22_RS21350 (L0Y22_21325) 4747673..4748578 - 906 WP_256542609.1 siderophore-interacting protein -
L0Y22_RS21355 (L0Y22_21330) 4748833..4749084 + 252 WP_010281712.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
L0Y22_RS21360 (L0Y22_21335) 4749081..4749368 + 288 WP_015842269.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
L0Y22_RS21365 (L0Y22_21340) 4749477..4750829 - 1353 WP_256542610.1 glutathione-disulfide reductase -
L0Y22_RS21370 (L0Y22_21345) 4750957..4751799 - 843 WP_015842271.1 23S rRNA (adenine(2030)-N(6))-methyltransferase RlmJ -
L0Y22_RS21375 (L0Y22_21350) 4752018..4752746 + 729 WP_043881851.1 DUF1266 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-84)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11074.15 Da        Isoelectric Point: 10.3527

>T231365 WP_015842269.1 NZ_CP090594:4749081-4749368 [Pectobacterium aroidearum]
MSYSVKFREDALKEWLKLDKTIQQQFAKKLKKCCENPHIPSAKLRGMKDCYKIKLRASGFRLVYEVIDDVLIIAVVAVGK
RERSGVYHLASERMR

Download         Length: 288 bp

>T231365 NZ_CP126343:733063-733359 [Escherichia coli]
ATGGAAAAACGCACACCACATACACGTTTGAGTCAGGTTAAAAAACTTGTCAATGCCGGGCAAGTTCGTACAACACGTAG
TGCCCTGTTAAATGCAGATGAGTTAGGTTTGGATTTTGATGGTATGTGTAATGTTATCATTGGATTATCAGAGAGCGACT
TTTATAAAAGCATGACCACCTACTCTGATCATACTATCTGGCAGGATGTTTACAGACCCAGGCTTGTTACAGGCCAGGTT
TATCTTAAAATTACGGTAATTCATGACGTACTGATCGTCTCGTTTAAGGAGAAGTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9117.47 Da        Isoelectric Point: 4.0637

>AT231365 WP_010281712.1 NZ_CP090594:4748833-4749084 [Pectobacterium aroidearum]
MPNIILSDTSASVSELKKNPMATVNAGDGLPVAILNRNQPAFYCIPADLYEKMLDALDDQELVKLIGERKNQPLVDVDLD
SFL

Download         Length: 252 bp

>AT231365 NZ_CP126343:733361-733756 [Escherichia coli]
ATGAAATGTCCGGTTTGCCACCAGGGAGAAATGGTTTCTGGCATTAAAGATATTCCATACACCTTCCGTGGACGAAAAAC
AGTATTGAAAGGTATCCACGGTTTATATTGTGTCCATTGCGAAGAGAGCATCATGAATAAAGAAGAGTCAGATGCTTTCA
TGGCGCAAGTAAAGGCATTTCGGGCTTCGGTGAATGCCGAAACAGTGGCACCTGAATTTATAGTGAAGGTTCGAAAAAAG
CTCTCTCTTACCCAAAAAGAGGCAAGCGAAATTTTTGGGGGAGGTGTAAATGCGTTTTCGCGTTACGAAAAAGGCAATGC
CCAACCTCATCCTTCCACAATCAAACTTTTACGTGTTCTGGATAAGCATCCAGAACTATTGAATGAAATCCGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3S0XQ75

Antitoxin

Source ID Structure
AlphaFold DB A0A0M2EZP0

References