Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 173940..174574 Replicon chromosome
Accession NZ_CP090594
Organism Pectobacterium aroidearum strain QJ034

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag L0Y22_RS00770 Protein ID WP_181845733.1
Coordinates 173940..174215 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag L0Y22_RS00775 Protein ID WP_181830203.1
Coordinates 174212..174574 (+) Length 121 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L0Y22_RS00755 (L0Y22_00755) 170961..172331 - 1371 WP_010281575.1 envelope stress sensor histidine kinase CpxA -
L0Y22_RS00760 (L0Y22_00760) 172328..173026 - 699 WP_012772878.1 envelope stress response regulator transcription factor CpxR -
L0Y22_RS00765 (L0Y22_00765) 173180..173704 + 525 WP_225181785.1 cell-envelope stress modulator CpxP -
L0Y22_RS00770 (L0Y22_00770) 173940..174215 + 276 WP_181845733.1 type II toxin-antitoxin system HicA family toxin Toxin
L0Y22_RS00775 (L0Y22_00775) 174212..174574 + 363 WP_181830203.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
L0Y22_RS00780 (L0Y22_00780) 174948..176135 + 1188 WP_180779137.1 sugar transporter -
L0Y22_RS00785 (L0Y22_00785) 176179..177081 + 903 WP_012772881.1 CDF family cation-efflux transporter FieF -
L0Y22_RS00790 (L0Y22_00790) 177289..178251 + 963 WP_012772882.1 6-phosphofructokinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(30-80)

Antitoxin

Uncharacterised protein family HicB

(61-113)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10051.64 Da        Isoelectric Point: 11.1875

>T231354 WP_181845733.1 NZ_CP090594:173940-174215 [Pectobacterium aroidearum]
MQGKIASLRKKQRETLSQIFKTPVLSGVKWSNVESLITALGGEIKEGSGSRVRFLLNGSIARFHRPHPSPDTDKGALVNL
REWLESIGVKP

Download         Length: 276 bp

>T231354 NZ_CP126341:c713066-712545 [Enterobacter cloacae]
GTGAATAACATGAAAATAGGGATTTTTTCAGATGACGTTGAGTATGATCTAAGCCATTTCGATTGCGGAGAAGAGAGCCT
AAACACCTTTCTGACGGCGCACCTGAAACGCCAGCATCGTGGGAAATTTTTGCGGGGTTACGTTCTTGTCGCATCCGGGG
AAAAGCCGCGGGTGTTGGGTTATTACACGCTGTCCGGGAGCTGCTTTGAAAAGGCGTACCTTCCTTCTAAAACCCAGCAG
AAGCGAGTGCCTTACAAAAATGTTCCCAGCGTCACGCTAGGCCGCCTGGCGATAGATAAACGCTTCCAGGGGCAAGGATT
GGGGGAGTTGCTGGTCACCCATGCTCTGAAAACGGTCTACCTGGCGTCTTTTGCCGTGGGTATCCACGGGATATTCGTAG
AAGCGCTGAACGGCAGCGCCAAAAACTTTTACCTTAAACTGGGGTTTATCGCCCTTCAGGCAGAGAATGAAAATACTCTC
TTCCTGCCGACTAAAACCATTGAAAGACTGTTTGCAGATTAA

Antitoxin


Download         Length: 121 a.a.        Molecular weight: 13577.41 Da        Isoelectric Point: 4.4981

>AT231354 WP_181830203.1 NZ_CP090594:174212-174574 [Pectobacterium aroidearum]
MTKALNTPNTMVVSGQPAIISYVPEIGMFRGKFIGLSGYCDFVADSINGLRNEGEISLREYLEDCQENGIEPYEREEKVK
TFTLRYPESFGERLTIAAAERQISVNTFIVETLNERMKQA

Download         Length: 363 bp

>AT231354 NZ_CP126341:c713339-713070 [Enterobacter cloacae]
ATGTCAGCACTAAAGAAACAGCGTATCGATCTACGCTTAACCGAAGACGACAAAAGCCTGATCGAAGAAGCAGCGGCAAT
GACGAACCAGTCAATTTCACAATTCATGGTAAGTACGGCCTCCGAACGCGCAGCAGAAGTGATTGAACAGCACCGCCGCC
TGATCCTCAACGAGGCATCCTGGAACCAGGTGATGGATGCGATCAGTAACCCGCCAACACCAAATGAACGACTGAAGCGA
GCAGCCAGGCGTCTCCAGGATCTGGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References