Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 3768926..3769452 Replicon chromosome
Accession NZ_CP090591
Organism Pectobacterium aroidearum strain QJ313

Toxin (Protein)


Gene name ccdB Uniprot ID -
Locus tag L0Y30_RS16830 Protein ID WP_256542272.1
Coordinates 3769147..3769452 (+) Length 102 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID -
Locus tag L0Y30_RS16825 Protein ID WP_198482245.1
Coordinates 3768926..3769144 (+) Length 73 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L0Y30_RS16795 3764300..3764431 - 132 WP_256542269.1 hypothetical protein -
L0Y30_RS16805 (L0Y30_16780) 3765178..3766437 + 1260 WP_256542270.1 integrase arm-type DNA-binding domain-containing protein -
L0Y30_RS16810 (L0Y30_16785) 3766582..3766752 - 171 WP_164669135.1 hypothetical protein -
L0Y30_RS16815 (L0Y30_16790) 3766893..3767234 + 342 WP_256542271.1 hypothetical protein -
L0Y30_RS16820 (L0Y30_16795) 3768124..3768867 + 744 WP_198482246.1 MobC family replication-relaxation protein -
L0Y30_RS16825 (L0Y30_16800) 3768926..3769144 + 219 WP_198482245.1 type II toxin-antitoxin system antitoxin CcdA Antitoxin
L0Y30_RS16830 (L0Y30_16805) 3769147..3769452 + 306 WP_256542272.1 type II toxin-antitoxin system toxin CcdB Toxin
L0Y30_RS16835 (L0Y30_16810) 3769837..3770880 - 1044 WP_256542273.1 DUF4435 domain-containing protein -
L0Y30_RS16840 (L0Y30_16815) 3771081..3772532 - 1452 WP_256542274.1 hypothetical protein -
L0Y30_RS16845 (L0Y30_16820) 3773004..3773216 - 213 WP_256542275.1 hypothetical protein -
L0Y30_RS16850 (L0Y30_16825) 3773542..3773784 - 243 WP_205947008.1 helix-turn-helix transcriptional regulator -
L0Y30_RS16855 (L0Y30_16830) 3773888..3774142 + 255 WP_039285388.1 helix-turn-helix transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 3765001..3773453 8452


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-100)

Antitoxin

Post-segregation antitoxin CcdA

(2-72)


Sequences

Toxin        


Download         Length: 102 a.a.        Molecular weight: 11690.53 Da        Isoelectric Point: 4.6761

>T231323 WP_256542272.1 NZ_CP090591:3769147-3769452 [Pectobacterium aroidearum]
MQFIVYEYKRASHYKMFVDVQSDIVDTPKRRMVIPLIEAHHLSEKVNKTLFPLIRIDGEDYRLMTTELSSVPVEVIGEAI
ADLGDYADEVKDAINLMFWGI

Download         Length: 306 bp

>T231323 NZ_CP126331:c19299-19015 [Citrobacter braakii]
GTGTATAAACTCACCGAACGGGCGGCAGAAGACTTCGCCGGGATTTATGATTATACGCTCTTGAAATTTGGTGAAGCTCA
GGCAGACCATTATACCGACGCACTTGAGGCATTTTTCGAGACACTGGCCGGAATGCCAGATATGGGACGTGACTACCATG
CCGTTCCTGGTGTAATGCGCATTGAATTTCAGCGACATGCCATTTTTTATACGGTTCGTGATACGGATATTCTGATTGCG
CGTATTTTGCACCAACAGATGAACCATAAACGCCATTTACTGTAA

Antitoxin


Download         Length: 73 a.a.        Molecular weight: 8174.14 Da        Isoelectric Point: 7.2038

>AT231323 WP_198482245.1 NZ_CP090591:3768926-3769144 [Pectobacterium aroidearum]
MKHRVSVTVDKDSYQVLSAAGVNISGLVNDAIGKEARRIKAEEWKKENREGMEEVARFIAQHGSFADENRNW

Download         Length: 219 bp

>AT231323 NZ_CP126331:c19534-19292 [Citrobacter braakii]
ATGGCCAGAACAACAAGCGTTACGATTGGCGAACAACTCGATTCGTTTATCAGTCGATTAATAGACAGTGGCCGTTACGG
CTCTGCAAGTGAAGTTATGCGCTCTGCGCTGCGATTGCTGGAGCAACAGGAAACAAACGATGAAGTTATTCGCCAGGCTG
TTATTACCGGGCTGGAAAGCGGTGAAAGCTCGCTATCACTGCGGGATATTGCAGCAGAAAGAAAACTGAGACATCGTGTA
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References