Detailed information of TA system TA231311

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tacAT/DUF1778(antitoxin)
• Location: 3753904..3754682
• Replicon: chromosome
• Accession: NZ_CP090590
• Organism: Pectobacterium aroidearum strain QJ315

Toxin (Protein)

• Gene name: TacT2
• Uniprot ID: -
• Locus tag: L0Y23_RS16755
• Protein ID: WP_256542279.1
• Coordinates: 3753904..3754392 (-)
• Length: 163 a.a.

Antitoxin (Protein)

• Gene name: TacA2
• Uniprot ID: -
• Locus tag: L0Y23_RS16760
• Protein ID: WP_205947014.1
• Coordinates: 3754389..3754682 (-)
• Length: 98 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L0Y23_RS16720 (L0Y23_16700)	3749164..3749376	-	213	WP_256542275.1	hypothetical protein	-
L0Y23_RS16725 (L0Y23_16705)	3749702..3749944	-	243	WP_205947008.1	helix-turn-helix transcriptional regulator	-
L0Y23_RS16730 (L0Y23_16710)	3750048..3750302	+	255	WP_039285388.1	helix-turn-helix transcriptional regulator	-
L0Y23_RS16735 (L0Y23_16715)	3750388..3750636	+	249	WP_256542276.1	helix-turn-helix transcriptional regulator	-
L0Y23_RS16740 (L0Y23_16720)	3750651..3750869	+	219	WP_256542277.1	type II toxin-antitoxin system antitoxin CcdA	-
L0Y23_RS16745 (L0Y23_16725)	3750917..3751176	+	260	Protein_3274	type II toxin-antitoxin system toxin CcdB	-
L0Y23_RS16750 (L0Y23_16730)	3751557..3753746	-	2190	WP_256542278.1	AAA family ATPase	-
L0Y23_RS16755 (L0Y23_16735)	3753904..3754392	-	489	WP_256542279.1	GNAT family N-acetyltransferase	Toxin
L0Y23_RS16760 (L0Y23_16740)	3754389..3754682	-	294	WP_205947014.1	DUF1778 domain-containing protein	Antitoxin
L0Y23_RS16765 (L0Y23_16745)	3754891..3755847	-	957	WP_256542280.1	AraC family transcriptional regulator	-
L0Y23_RS16770 (L0Y23_16750)	3755963..3757150	+	1188	WP_256542281.1	MFS transporter	-
L0Y23_RS16775 (L0Y23_16755)	3757277..3757699	-	423	WP_012773533.1	MarR family transcriptional regulator	-
L0Y23_RS16780 (L0Y23_16760)	3757860..3758879	+	1020	WP_256542282.1	alpha/beta hydrolase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• GNAT domain (76-143)

Antitoxin

• Vibrio phage ICP1, Orf50 (14-88)

Sequences

Toxin

Protein

• Length: 163 a.a.
• Molecular weight: 17421.24 Da
• Isoelectric Point: 7.8046

>T231311 WP_256542279.1 NZ_CP090590:c3754392-3753904 [Pectobacterium aroidearum]
MISAPEPLHAEHVLSSFCCGVESMDNWLKQRAMKNQVTGASRTFVSCDGSKVLAYYSLASSAVATNAAPGRFRRNMPDPI
PVVVLGRLAVDKSLHGQGVGRALVRDVGLRVIQVADTIGIRGMLVHALSDEAREFYLRVGFEPSPIDPMLLMVTLGDLVG
SV

Nucleotide

• Length: 489 bp

>T231311 NZ_CP126326:8982-9287 [Salmonella enterica subsp. enterica]
ATGCAGTTTAAGGTTTACACCTATAAAAGGGAGAGTCGCTACACCCTGTTCGTGGATGTCCAGAGTGACATTATCGACAC
CCCCGGACGGCGGATGGTGATCCCGCTGGCCAGCGCCCGTCTGCTGTCGGATAAGGTATCCCGCGAACTTTATCCTGTGG
TACATATCGGGGATGAGAGCTGGCGTCTGATGACCACAGATATGGCCAGTGTGCCGGCCTCAGTCATCGGGGAAGAGGTG
GCCGATCTCAGTCACCGGGAGAACGATATCAAAAACGCCATTAACCTGATGTTCTGGGGGATTTGA

Antitoxin

Protein

• Length: 98 a.a.
• Molecular weight: 10892.43 Da
• Isoelectric Point: 10.1968

>AT231311 WP_205947014.1 NZ_CP090590:c3754682-3754389 [Pectobacterium aroidearum]
MPATNSVSVKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIDQRIIMADPDAYQEFLTRLDQAPSPN
AALRKTMQTSAPWEQKK

Nucleotide

• Length: 294 bp

>AT231311 NZ_CP126326:8762-8980 [Salmonella enterica subsp. enterica]
ATGAAGCAGCGCATTACAGTGACAGTGGACAGCGACAGCTATCAGCTGCTCAAGGCATACGACGTGAATATCTCCGGTCT
GGTCAGTACGGCCATGCAGAACGAAGCCCGCCGTCTGCGAGCCGAACGCTGGCAGGAAGAAAACCGGGAAGGTATGGCTG
AGGTGGCCAGCTTTATAGAGGCTAACGGATCGTTTGCTGACGAAAACAGGAACTGGTGA