Detailed information of TA system TA231310

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): ccdAB/CcdA(antitoxin)
• Location: 3745086..3745612
• Replicon: chromosome
• Accession: NZ_CP090590
• Organism: Pectobacterium aroidearum strain QJ315

Toxin (Protein)

• Gene name: ccdB
• Uniprot ID: -
• Locus tag: L0Y23_RS16705
• Protein ID: WP_256542272.1
• Coordinates: 3745307..3745612 (+)
• Length: 102 a.a.

Antitoxin (Protein)

• Gene name: ccdA
• Uniprot ID: -
• Locus tag: L0Y23_RS16700
• Protein ID: WP_198482245.1
• Coordinates: 3745086..3745304 (+)
• Length: 73 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L0Y23_RS16670	3740460..3740591	-	132	WP_256542269.1	hypothetical protein	-
L0Y23_RS16680 (L0Y23_16660)	3741338..3742597	+	1260	WP_256542270.1	integrase arm-type DNA-binding domain-containing protein	-
L0Y23_RS16685 (L0Y23_16665)	3742742..3742912	-	171	WP_164669135.1	hypothetical protein	-
L0Y23_RS16690 (L0Y23_16670)	3743053..3743394	+	342	WP_256542271.1	hypothetical protein	-
L0Y23_RS16695 (L0Y23_16675)	3744284..3745027	+	744	WP_198482246.1	MobC family replication-relaxation protein	-
L0Y23_RS16700 (L0Y23_16680)	3745086..3745304	+	219	WP_198482245.1	type II toxin-antitoxin system antitoxin CcdA	Antitoxin
L0Y23_RS16705 (L0Y23_16685)	3745307..3745612	+	306	WP_256542272.1	type II toxin-antitoxin system toxin CcdB	Toxin
L0Y23_RS16710 (L0Y23_16690)	3745997..3747040	-	1044	WP_256542273.1	DUF4435 domain-containing protein	-
L0Y23_RS16715 (L0Y23_16695)	3747241..3748692	-	1452	WP_256542274.1	hypothetical protein	-
L0Y23_RS16720 (L0Y23_16700)	3749164..3749376	-	213	WP_256542275.1	hypothetical protein	-
L0Y23_RS16725 (L0Y23_16705)	3749702..3749944	-	243	WP_205947008.1	helix-turn-helix transcriptional regulator	-
L0Y23_RS16730 (L0Y23_16710)	3750048..3750302	+	255	WP_039285388.1	helix-turn-helix transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	-	3741161..3749613	8452

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin CcdB (2-100)

Antitoxin

• Post-segregation antitoxin CcdA (2-72)

Sequences

Toxin

Protein

• Length: 102 a.a.
• Molecular weight: 11690.53 Da
• Isoelectric Point: 4.6761

>T231310 WP_256542272.1 NZ_CP090590:3745307-3745612 [Pectobacterium aroidearum]
MQFIVYEYKRASHYKMFVDVQSDIVDTPKRRMVIPLIEAHHLSEKVNKTLFPLIRIDGEDYRLMTTELSSVPVEVIGEAI
ADLGDYADEVKDAINLMFWGI

Nucleotide

• Length: 306 bp

>T231310 NZ_CP126326:c7791-7375 [Salmonella enterica subsp. enterica]
GTGAAGAAAATGTATATGCTCGATACCAACATCTGCTCATTCATCATGTGCGAGCAGCCAGAAGCGGTGCTGAAGCGCCT
GGAGCAGGCGGTACTGCGCGGACACCGTATCATGGTCTCGGCCATCACTTACTCCGAGATGCGCTTCGGTGCCACCGGCC
CGAAGGCCTCGCCGCGCCACATTGAGCTGGTTGACGCGTTCTGCGCCCGCCTCGATGCCGTCCTGCCCTGGGACCGCGCC
GCGGTGGATGCGACCACGGAGATTAAAGTGGCGCTGCGCCTCGCCGGGACGCCGATCGGCCCGAACGACACGGCGATTGC
CGGGCATGCCATCGCCGCCGGCGCCGTTCTGGTGACGAATAATGTGAGGGAGTTTGAGCGGGTACCGGGCCTGGTACTGG
AAGACTGGGTGAAGTAA

Antitoxin

Protein

• Length: 73 a.a.
• Molecular weight: 8174.14 Da
• Isoelectric Point: 7.2038

>AT231310 WP_198482245.1 NZ_CP090590:3745086-3745304 [Pectobacterium aroidearum]
MKHRVSVTVDKDSYQVLSAAGVNISGLVNDAIGKEARRIKAEEWKKENREGMEEVARFIAQHGSFADENRNW

Nucleotide

• Length: 219 bp

>AT231310 NZ_CP126326:c8018-7788 [Salmonella enterica subsp. enterica]
ATGAGAACCGTATCCATTTTTAAAAACGGCAACAACCGCGCCATCCGTCTGCCCCGCGATCTGGATTTTGAGGGGGTGAG
CGAGCTGGAGATCGTCCGGGAAGGGGACAGCATTATCCTGCGTCCCGTCCGGCCGACCTGGGGTTCGTTCGCGCAGCTCG
AAAAAGCTGACCCGGACTTTATGGCGGAGCGCGAGGACGTTGTCACCGACGAAGGACGATTTAACCTGTGA