Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3510057..3510682 Replicon chromosome
Accession NZ_CP090590
Organism Pectobacterium aroidearum strain QJ315

Toxin (Protein)


Gene name Hha Uniprot ID C6DB72
Locus tag L0Y23_RS15705 Protein ID WP_005976087.1
Coordinates 3510479..3510682 (+) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID C6DB73
Locus tag L0Y23_RS15700 Protein ID WP_005976089.1
Coordinates 3510057..3510425 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L0Y23_RS15685 (L0Y23_15670) 3505688..3508816 + 3129 WP_015839362.1 efflux RND transporter permease subunit -
L0Y23_RS15690 (L0Y23_15675) 3509051..3509299 + 249 WP_015839361.1 type B 50S ribosomal protein L31 -
L0Y23_RS15695 (L0Y23_15680) 3509317..3509460 + 144 WP_005976091.1 type B 50S ribosomal protein L36 -
L0Y23_RS15700 (L0Y23_15685) 3510057..3510425 + 369 WP_005976089.1 Hha toxicity modulator TomB Antitoxin
L0Y23_RS15705 (L0Y23_15690) 3510479..3510682 + 204 WP_005976087.1 HHA domain-containing protein Toxin
L0Y23_RS15715 (L0Y23_15700) 3511429..3511749 + 321 WP_015839360.1 MGMT family protein -
L0Y23_RS15720 (L0Y23_15705) 3511769..3512350 - 582 WP_256542207.1 YbaY family lipoprotein -
L0Y23_RS15725 (L0Y23_15710) 3512563..3513426 + 864 WP_015839358.1 acyl-CoA thioesterase II -
L0Y23_RS15730 (L0Y23_15715) 3513556..3514866 + 1311 WP_225182003.1 IS4 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 3513556..3514866 1310


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-118)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8145.52 Da        Isoelectric Point: 8.9008

>T231309 WP_005976087.1 NZ_CP090590:3510479-3510682 [Pectobacterium aroidearum]
MKKIDYLMRLRKCTTIDTLERVIEKNKYELSNDELEMFFSAADHRLAELTMNKLYDKVPTAVWRYVR

Download         Length: 204 bp

>T231309 NZ_CP126325:4637282-4637593 [Salmonella enterica subsp. enterica]
GTGCATGTTATCAGCCGAAAACCGTTCAATGAAGCGATGCTCATGTATCCAAACCATGAGCTTGCTCTCACTGAGTTGCT
GAATGTTCTGGAGAAAAAAACATTCACTCAGCCTGAAGAGATGAAGCGGTATATTCCTTCACTGGATAATTTTAAGCACA
GAGATAAATGGTGGGTGATTGATGTTTCTGGTAACAGCCTGAGACTCATTTCCTACATAGATTTCAGGTTACATAAGATA
TTTGTGAAACATATCGTTTCCCATGCCGAATATGACAAACTGACCGCATATTATCGGGGTAATAAAGAATGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14032.77 Da        Isoelectric Point: 4.4787

>AT231309 WP_005976089.1 NZ_CP090590:3510057-3510425 [Pectobacterium aroidearum]
MDEYTPKHYDIAQLRFLCENLCDESIATLGDSSHGWVNDPTSAINLQLNELIEHIATFILTFKIKYPNESELSEQVEKYL
DDTYVLFSNYGINDAELRRWQKSKAKLFGMFSGENVCTPAKT

Download         Length: 369 bp

>AT231309 NZ_CP126325:4637590-4638036 [Salmonella enterica subsp. enterica]
ATGAGAACTCATCGTCAGATGGATGCAACCAGCGCAAAAAAGATCGTTGATACCTTCAGCGATGCGGTAAAAACCGTCCC
ACTGATGGGGGAAGACCGAAATGACAATGAGTATCGCAGGGCACTAGCGCTAGTGGAGTTTCTGGTCGACCACGACGATC
TTGAAAACCCACTATTTGAATTACTCTGTGCCCGAATCAGTGAATACGAAAAACATGCGCCGGAATTCAAAGCACTCAAC
CAACACCTGGAGAAAACGCCCCCTGGCGTTTCAGTATTGCGAACGCTCATGGATCAATACGGTCTCAAAGCAGCAGATCT
TGCCAACGAACTTGGTTCTAAATCGAACGTCAGCAACATCTTAAATGGCCGCAGAGCACTAACGGTTAATCATATTAAAG
CGCTTACACAACGCTTTAAACTACCAGCGGATGCCTTCATCGAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1D7Z3F0

Antitoxin

Source ID Structure
AlphaFold DB A0A1D7Z3G5

References