Detailed information of TA system TA231306

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 211084..211701
• Replicon: chromosome
• Accession: NZ_CP090590
• Organism: Pectobacterium aroidearum strain QJ315

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: C6DHN3
• Locus tag: L0Y23_RS00945
• Protein ID: WP_010281507.1
• Coordinates: 211522..211701 (-)
• Length: 60 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: L0Y23_RS00940
• Protein ID: WP_181847422.1
• Coordinates: 211084..211494 (-)
• Length: 137 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L0Y23_RS00925 (L0Y23_00925)	206909..207952	-	1044	WP_012772905.1	DNA-binding transcriptional regulator CytR	-
L0Y23_RS00930 (L0Y23_00930)	208229..210427	-	2199	WP_256542703.1	primosomal protein N'	-
L0Y23_RS00935 (L0Y23_00935)	210742..210957	+	216	WP_012772907.1	50S ribosomal protein L31	-
L0Y23_RS00940 (L0Y23_00940)	211084..211494	-	411	WP_181847422.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
L0Y23_RS00945 (L0Y23_00945)	211522..211701	-	180	WP_010281507.1	type II toxin-antitoxin system HicA family toxin	Toxin
L0Y23_RS00950 (L0Y23_00950)	211799..212809	-	1011	WP_181845671.1	iron ABC transporter permease	-
L0Y23_RS00955 (L0Y23_00955)	212806..213768	-	963	WP_194431281.1	ABC transporter substrate-binding protein	-
L0Y23_RS00960 (L0Y23_00960)	213778..214575	-	798	WP_256542704.1	ABC transporter ATP-binding protein	-
L0Y23_RS00965 (L0Y23_00965)	214791..215108	-	318	WP_005973355.1	met regulon transcriptional regulator MetJ	-
L0Y23_RS00970 (L0Y23_00970)	215296..216456	+	1161	WP_256542705.1	cystathionine gamma-synthase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (4-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-128)

Sequences

Toxin

Protein

• Length: 60 a.a.
• Molecular weight: 6560.69 Da
• Isoelectric Point: 10.7838

>T231306 WP_010281507.1 NZ_CP090590:c211701-211522 [Pectobacterium aroidearum]
MDSRTLIAEIKADGWELIRVNGSHHHFMHPSKPGLVTIPHPKKDLPIGTVKSIRKQAGI

Nucleotide

• Length: 180 bp

>T231306 NZ_CP126325:c4160753-4160469 [Salmonella enterica subsp. enterica]
ATGACTTATGAACTGGAATTCGACCCGAGGGCCTTAAAAGAGTGGCATAAGCTGGGCGATACGGTGAAGGCTCAGCTTAA
GAAAAAGTTGGCTGATGTGCTATTGAACCCCAGAATCGACTCTGCCCGTTTAAACGGTCTTCCTGACTGCTATAAAATTA
AGCTTAAATCGTCCGGTTATCGTCTGGTGTACCAGGTTCGGGATGACGTTGTGATTGTGTTTGTTGTTGCGGTCGGCAAG
CGAGAACATTCAGCCGTCTATCACGATGCAAACGAACGGCTTTAG

Antitoxin

Protein

• Length: 137 a.a.
• Molecular weight: 14591.49 Da
• Isoelectric Point: 4.4493

>AT231306 WP_181847422.1 NZ_CP090590:c211494-211084 [Pectobacterium aroidearum]
MFYPIAIEAGDDTHAYGVTVPDLPGCFSAGDTLDDAIANAKEAITGHIELLVEMGQDIPTVSTVGQLAKRSEYAGYTWAV
VDIDVTRLMGGSEKINVTLPKSLIDRIDRCVASNPEFKSRSGFLAQAALERISSSR

Nucleotide

• Length: 411 bp

>AT231306 NZ_CP126325:c4160985-4160743 [Salmonella enterica subsp. enterica]
ATGGCCACGCTGAACGTCCGTCTGGATGACAAACTCAAAAATGAGGCTTATGCCGTGCTGGAAAAACTGAACATTACTCC
AACGGAAGCCGTGCGATTACTGTTCCAGTACGTCGCGGAAACGGGGCGCATGCCAGTGAAAACCGTCACTCTTAGCGACA
GTGAAGATGCACTGATTCAGACAGTTCGGGAGAGGCTGTCTAGTCCGCAAAAGGGAATCAAGGTTAGTCTGGATGACTTA
TGA

Structures

Toxin

• AlphaFold DB: A0A7W2I1S0