Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 4748849..4749384 Replicon chromosome
Accession NZ_CP090589
Organism Pectobacterium aroidearum strain QJ316

Toxin (Protein)


Gene name relE Uniprot ID C6DJA0
Locus tag L0Y28_RS21365 Protein ID WP_015842269.1
Coordinates 4749097..4749384 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q6DB37
Locus tag L0Y28_RS21360 Protein ID WP_010281712.1
Coordinates 4748849..4749100 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L0Y28_RS21330 (L0Y28_21305) 4744242..4744679 + 438 WP_256542605.1 RICIN domain-containing protein -
L0Y28_RS21335 (L0Y28_21310) 4744967..4745278 + 312 WP_256542606.1 LysR substrate-binding domain-containing protein -
L0Y28_RS21340 (L0Y28_21315) 4745320..4745943 - 624 WP_256542607.1 LysE family translocator -
L0Y28_RS21345 (L0Y28_21320) 4746125..4746829 + 705 WP_256542608.1 SMI1/KNR4 family protein -
L0Y28_RS21350 (L0Y28_21325) 4746899..4747654 + 756 WP_181845543.1 thiol:disulfide interchange protein DsbG -
L0Y28_RS21355 (L0Y28_21330) 4747689..4748594 - 906 WP_256542609.1 siderophore-interacting protein -
L0Y28_RS21360 (L0Y28_21335) 4748849..4749100 + 252 WP_010281712.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
L0Y28_RS21365 (L0Y28_21340) 4749097..4749384 + 288 WP_015842269.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
L0Y28_RS21370 (L0Y28_21345) 4749493..4750845 - 1353 WP_256542610.1 glutathione-disulfide reductase -
L0Y28_RS21375 (L0Y28_21350) 4750973..4751815 - 843 WP_015842271.1 23S rRNA (adenine(2030)-N(6))-methyltransferase RlmJ -
L0Y28_RS21380 (L0Y28_21355) 4752034..4752762 + 729 WP_043881851.1 DUF1266 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-84)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11074.15 Da        Isoelectric Point: 10.3527

>T231303 WP_015842269.1 NZ_CP090589:4749097-4749384 [Pectobacterium aroidearum]
MSYSVKFREDALKEWLKLDKTIQQQFAKKLKKCCENPHIPSAKLRGMKDCYKIKLRASGFRLVYEVIDDVLIIAVVAVGK
RERSGVYHLASERMR

Download         Length: 288 bp

>T231303 NZ_CP126325:3659458-3659733 [Salmonella enterica subsp. enterica]
ATGAATGCCTCCGGCGTCAGCGTCCGCCACATCAACAGCGAAACCTGCATGACCACCAGTTACTCACATATCCCCAGCCA
GCACCTTAAGGGTGACTGGCAGGAAGACGCGGGATTTGAGACCGGGCGCAGCGTGACCGTGAAGATCTCCGAGGGGTGTT
TGATCCTGATTGCAGAGACGGACGAAGTGAGGGATTTACGGAAGGAGCTTTATCAGGTGAAAAAGTCGATGAAGCATATT
AAGGCGGGGGTAAATAATGTGGTGAACGGGGATTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9117.47 Da        Isoelectric Point: 4.0637

>AT231303 WP_010281712.1 NZ_CP090589:4748849-4749100 [Pectobacterium aroidearum]
MPNIILSDTSASVSELKKNPMATVNAGDGLPVAILNRNQPAFYCIPADLYEKMLDALDDQELVKLIGERKNQPLVDVDLD
SFL

Download         Length: 252 bp

>AT231303 NZ_CP126325:c3659723-3659301 [Salmonella enterica subsp. enterica]
TTCACCACATTATTTACCCCCGCCTTAATATGCTTCATCGACTTTTTCACCTGATAAAGCTCCTTCCGTAAATCCCTCAC
TTCGTCCGTCTCTGCAATCAGGATCAAACACCCCTCGGAGATCTTCACGGTCACGCTGCGCCCGGTCTCAAATCCCGCGT
CTTCCTGCCAGTCACCCTTAAGGTGCTGGCTGGGGATATGTGAGTAACTGGTGGTCATGCAGGTTTCGCTGTTGATGTGG
CGGACGCTGACGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTAATTCTCCGCCGGATGCTGGCTGATTGTGGA
GCTCAGGGTGAGCGAGTATGGGCGCGACATCCTGGCACCGCGCCTCCCTCTCCCCGGCCAGTACCGGGCGGTGATGAGCA
ACCGGCTACCGGGGCCGTATTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3S0XQ75

Antitoxin

Source ID Structure
AlphaFold DB A0A0M2EZP0

References