Detailed information of TA system TA231299

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/Cpta(toxin)
• Location: 3972176..3972836
• Replicon: chromosome
• Accession: NZ_CP090589
• Organism: Pectobacterium aroidearum strain QJ316

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: -
• Locus tag: L0Y28_RS17705
• Protein ID: WP_043881709.1
• Coordinates: 3972176..3972550 (-)
• Length: 125 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: C6D8Y5
• Locus tag: L0Y28_RS17710
• Protein ID: WP_012773340.1
• Coordinates: 3972570..3972836 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L0Y28_RS17680 (L0Y28_17655)	3967553..3968452	-	900	WP_012773347.1	site-specific tyrosine recombinase XerD	-
L0Y28_RS17685 (L0Y28_17660)	3968764..3970092	+	1329	WP_181845156.1	MFS transporter	-
L0Y28_RS17690 (L0Y28_17665)	3970255..3970773	+	519	WP_012773344.1	flavodoxin FldB	-
L0Y28_RS17695 (L0Y28_17670)	3970802..3971125	+	324	WP_180777498.1	hypothetical protein	-
L0Y28_RS17700 (L0Y28_17675)	3971171..3972106	-	936	WP_256542328.1	23S rRNA (adenine(1618)-N(6))-methyltransferase RlmF	-
L0Y28_RS17705 (L0Y28_17680)	3972176..3972550	-	375	WP_043881709.1	protein YgfX	Toxin
L0Y28_RS17710 (L0Y28_17685)	3972570..3972836	-	267	WP_012773340.1	FAD assembly factor SdhE	Antitoxin
L0Y28_RS17715 (L0Y28_17690)	3973072..3974073	+	1002	WP_256542329.1	tRNA-modifying protein YgfZ	-
L0Y28_RS17720 (L0Y28_17695)	3974253..3974900	-	648	WP_012773338.1	hemolysin III family protein	-
L0Y28_RS17725 (L0Y28_17700)	3975313..3975921	+	609	WP_181829659.1	HD domain-containing protein	-
L0Y28_RS17730 (L0Y28_17705)	3975965..3976969	+	1005	WP_256542330.1	LacI family DNA-binding transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Inner membrane protein YgfX (2-119)

Antitoxin

• Flavinator of succinate dehydrogenase (8-79)

Sequences

Toxin

Protein

• Length: 125 a.a.
• Molecular weight: 14673.34 Da
• Isoelectric Point: 10.6585

>T231299 WP_043881709.1 NZ_CP090589:c3972550-3972176 [Pectobacterium aroidearum]
MQLLSLIVHGLLVLLILLAPWPDGYAWLWLCLVTMVMFGFIRSQRNIKSRQGEIVLLSETTLNWRQQEWQIVKRPWLLKN
GVLLSLQAVNGKDRQQLWLASDSMGDDEWRHLRQLLLQQKNWAR

Nucleotide

• Length: 375 bp

>T231299 NZ_CP126325:1902251-1902604 [Salmonella enterica subsp. enterica]
GTGTGGACAATTAAAACAACGGATACGTTTGATCGCTGGTTTGCCTCGCTCAACGATACCGACAGGGTCAGCGTGCTTGC
AGCACTGCTGGTCCTGCGAGAAAAGGGGCCGGGTTTGTCCAGACCTTATGCCGATACGGTCAGAGGTTCCCGTTACAGCA
ACATGAAAGAACTACGTATTCAGAGTCGGGGCGAGCCGATACGGGCGTTTTTCGCTTTTGACCCGACCCGTACCGGCATT
GTGCTTTGTGCCGGAAATAAGGTCGGCAATGAAAAACGTTTTTACGATGAGATGCTCCCTGTTGCTGACAGGGAATTCAC
GAACTGGCTGAACACATTAAAAGAGAAGGAGTAA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10465.94 Da
• Isoelectric Point: 6.2223

>AT231299 WP_012773340.1 NZ_CP090589:c3972836-3972570 [Pectobacterium aroidearum]
MEIDNKSRIHWACRRGMRELDIAIMPFFEHDYDTLSDSDKRTFVRLLQSDDPDLFNWLMNHGEPKDGELKRMISLIQTRN
KDRGPVAM

Nucleotide

• Length: 267 bp

>AT231299 NZ_CP126325:1902609-1902911 [Salmonella enterica subsp. enterica]
ATGGGCAGAACGCTGGAACAGCTTATTGCGGATGAGAAACCTGAAGTCGTGGCCGAAGCTCAGGCGATGGCGACGGACAT
CCTGCTCAACATTCACCTTGCCGAACTGCGTGAGAAAGTACAGAAAACGCAGGTGGAGATGGCACAGGCGCTGGGCATCA
GGCAACCTACCGTTGCAGGAATGGAAAAACCAGGGCGCGATCTGAAGCTTTCCACTCTCAAACGCTACGTTGAAGCGACT
GGCGGTAAGCTACGTCTTGATGTTGAACTGCCGGATGGTTCTCACTACGGATTTGTACTGTAA

Structures

Antitoxin

• AlphaFold DB: A0A7W2E501