Detailed information of TA system TA231292

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/-
• Location: 173940..174574
• Replicon: chromosome
• Accession: NZ_CP090589
• Organism: Pectobacterium aroidearum strain QJ316

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: L0Y28_RS00770
• Protein ID: WP_181845733.1
• Coordinates: 173940..174215 (+)
• Length: 92 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: L0Y28_RS00775
• Protein ID: WP_181830203.1
• Coordinates: 174212..174574 (+)
• Length: 121 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L0Y28_RS00755 (L0Y28_00755)	170961..172331	-	1371	WP_010281575.1	envelope stress sensor histidine kinase CpxA	-
L0Y28_RS00760 (L0Y28_00760)	172328..173026	-	699	WP_012772878.1	envelope stress response regulator transcription factor CpxR	-
L0Y28_RS00765 (L0Y28_00765)	173180..173704	+	525	WP_225181785.1	cell-envelope stress modulator CpxP	-
L0Y28_RS00770 (L0Y28_00770)	173940..174215	+	276	WP_181845733.1	type II toxin-antitoxin system HicA family toxin	Toxin
L0Y28_RS00775 (L0Y28_00775)	174212..174574	+	363	WP_181830203.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
L0Y28_RS00780 (L0Y28_00780)	174948..176135	+	1188	WP_180779137.1	sugar transporter	-
L0Y28_RS00785 (L0Y28_00785)	176179..177081	+	903	WP_012772881.1	CDF family cation-efflux transporter FieF	-
L0Y28_RS00790 (L0Y28_00790)	177289..178251	+	963	WP_012772882.1	6-phosphofructokinase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (30-80)

Antitoxin

• Uncharacterised protein family HicB (61-113)

Sequences

Toxin

Protein

• Length: 92 a.a.
• Molecular weight: 10051.64 Da
• Isoelectric Point: 11.1875

>T231292 WP_181845733.1 NZ_CP090589:173940-174215 [Pectobacterium aroidearum]
MQGKIASLRKKQRETLSQIFKTPVLSGVKWSNVESLITALGGEIKEGSGSRVRFLLNGSIARFHRPHPSPDTDKGALVNL
REWLESIGVKP

Nucleotide

• Length: 276 bp

>T231292 NZ_CP126323:4600392-4600703 [Salmonella enterica subsp. enterica]
GTGCATGTTATCAGCCGAAAACCGTTCAATGAAGCGATGCTCATGTATCCAAACCATGAGCTTGCTCTCACTGAGTTGCT
GAATGTTCTGGAGAAAAAAACACTCACTCAGCCTGAAGAGATGAAGCGGTATATTCCTTCACTGGATAATTTTAAGCACA
GAGATAAATGGTGGGTGATTGATGTTTCTGGTAACAGCCTGAGACTCATTTCCTACATAGATTTCAGGTTACATAAGATA
TTTGTGAAACATATCGTTTCCCATGCCGAATATGACAAACTGACCGCATATGATCGGGGTAATAAAGAATGA

Antitoxin

Protein

• Length: 121 a.a.
• Molecular weight: 13577.41 Da
• Isoelectric Point: 4.4981

>AT231292 WP_181830203.1 NZ_CP090589:174212-174574 [Pectobacterium aroidearum]
MTKALNTPNTMVVSGQPAIISYVPEIGMFRGKFIGLSGYCDFVADSINGLRNEGEISLREYLEDCQENGIEPYEREEKVK
TFTLRYPESFGERLTIAAAERQISVNTFIVETLNERMKQA

Nucleotide

• Length: 363 bp

>AT231292 NZ_CP126323:4600700-4601146 [Salmonella enterica subsp. enterica]
ATGAGAACTCATCGTCAGATGGATGCAACCAGCGCAAAAAAGATCGTTGATACCTTCAGCGATGCGGTAAAAAGCGTCCC
ACTGATGGGGGAAGACCGAAATGACAATGAGTATCGCAGGGCACTAGCGCTAGTGGAGTTTCTGGTCGACCACGACGATC
TTGAAAATCCACTATTTGAATTGCTCTGTGCCCGAATCAGTGAATACGAAAAACATGCGCCGGAATTCAAAGCACTCAAC
CAACACCTGGAGAAAACGCCCCCTGGCGTTTCAGTATTGCGAACGCTCATGGATCAATACGGTCTCAAAGCAGCAGATCT
TGCCAACGAACTTGGTTCTAAATCGAACGTCAGCAACATCTTAAATGGCCGCAGAGCACTAACGGTTAATCATATTAAAG
CGCTTACACAACGCTTCAAACTACCAGCAGATGCCTTCATCGAGTAG